[car home New Car Launches] On August 16th, the pagani Roadster was officially released at the Pebble Beach Auto Show, with the same power configuration as the hardtop version, with a global limited edition of 130 V12 engines and an overseas price of 3.4 million US dollars, about 24.654 million yuan.

　　Although the new car is a convertible version, the net weight of the car body is the same as that of the hardtop version, both of which are 1280 kg. The design of the convertible structure part is ingenious, and it can be completely disassembled with a skylight. Not surprisingly, the new car adopts carbon fiber single shell body, and continues the traditional design of butterfly door with upward folding, which is highly recognizable. The front engine room cover is smooth without too many curves. The headlight group continues to adopt the traditional double-willow shape, and the interior decoration part of the headlight also uses carbon fiber. In addition, the air inlet of the front face is designed to be large, which makes the new car have strong heat dissipation ability.

　　The rear half of the car body uses an integrated rear cabin cover, and there is an observation window at the engine, so you can enjoy the V12 engine from AMG at any time. In the rear part, the classic central four-outlet exhaust pipe divides the color matching spoiler into two parts, and the taillights on both sides are arranged vertically. The overall hollow shape of the rear part is obvious and very layered.

　　The interior continues the style and layout of the pagani supercar interior. There is no central control electronic screen, all physical buttons are decorated with a circle of blue lights, and almost all parts of the car are covered with leather or carbon fiber panels.

　　In terms of power, the new car is still equipped with a 6.0T twin-turbo V12 engine provided by AMG, with a maximum power of 864 HP and a peak torque of 1,100 Nm. The transmission system is matched with Xtrac 7-speed sequential gearbox, and manual transmission is also optional. In addition, the new car will be equipped with active suspension and innovative sensor system of Pirelli Cyber Tyre, which can monitor the status of Pirelli P Zero Corsa, Winter and Trofeo RS tires and transmit the real-time tire information back to the on-board computer, so as to regulate the traction control system, which can control the stability of the vehicle more accurately, thus exerting stronger performance potential under the premise of safety. (Text/car home Dai Wei)

"The new Braille books in the library are clearly printed, and the current Braille is used correctly, which is very suitable for blind people to read. There is also a special reading table for us blind people. How thoughtful! " On May 4th this year, in the reading room for the blind of Hefei Library, Mr. Jiang, a visually impaired person, said happily to You Yi, assistant procurator of the Third Procuratorate of Shushan District Procuratorate of Hefei.

Teacher Jiang experienced this change in Hefei Library, which benefited from the first administrative public interest litigation case of visually barrier-free information construction in our province handled by Shushan District Procuratorate. In January last year, the prosecutor of the hospital found that the daily reading needs of visually impaired people with disabilities were difficult to meet, Braille books were expensive and difficult to buy, and the borrowing process in some libraries was not smooth. After visiting local disabled persons’ federations, public welfare voluntary organizations and relevant administrative organs, and listening to the opinions of the visually impaired, the prosecutor further learned that the reading room for the blind in Hefei Library could not be used normally, and the configuration of barrier-free information exchange equipment such as Braille books, audio books, voice recording, large character reading equipment and software was not perfect, which made it inconvenient for the visually impaired to borrow. In view of the fact that the reading rights and interests of visually impaired people have not been effectively guaranteed, and the social public interests have been infringed, under the guidance of the provincial procuratorate and the designated jurisdiction of the Hefei Procuratorate, on April 12, 2022, the Shushan District Procuratorate filed an administrative public interest litigation investigation.

Since then, the hospital has held a round table meeting with relevant regulatory authorities to discuss the statutory duties of administrative organs, the implementation of the demands of disabled representatives, the rectification plan, and regulatory measures, and clarified the direction of rectification. On April 15th, the Procuratorate of Shushan District issued a pre-litigation procuratorial proposal to Hefei Culture and Tourism Bureau, stressing that promoting barrier-free environment construction is an important prerequisite for ensuring the disabled and other social members to fully and equally participate in social life. Information accessibility is an important part of barrier-free environment construction and an inevitable requirement for building an information society in an all-round way and promoting social fairness and justice. Hefei Library, as a subordinate unit of Hefei Culture and Tourism Bureau, has some shortcomings in the guarantee of barrier-free information construction. The bureau is responsible for the development of urban public culture and should perform its supervision and management duties according to law to avoid the infringement of social public interests. In view of this, according to the Public Library Law, Regulations on Barrier-free Environment Construction, Regulations on Protection of Disabled Persons in Anhui Province and Administrative Measures on Barrier-free Environment Construction in Anhui Province, this proposal requires Hefei Library to allocate Braille books and related reading equipment according to regulations, optimize the lending process, improve the construction of barrier-free information, and ensure that special groups can enjoy social public cultural services equally.

After receiving the procuratorial suggestions, Hefei Municipal Bureau of Culture and Tourism attached great importance to it and decided to launch a special campaign of "protecting the reading rights of visually impaired people" throughout the city, urging more than 30 libraries in Hefei and related communities to improve the construction of visually impaired reading facilities in time, speed up the transformation of information barrier-free environment, ensure the normal use of reading rooms for the blind, and at the same time, add existing Braille books for social sciences and literature. For this special rectification, Hefei Culture and Tourism Bureau gave a written reply to the Shushan District Procuratorate.

In order to consolidate the results of public interest litigation, on May 4th this year, the Procuratorate of Shushan District specially invited three representatives of visually impaired people and two volunteers of procuratorial cloud platform and supervisors of barrier-free environment construction to walk into Hefei Library for "looking back". Everyone browsed more than 200 new Braille books purchased by the library and experienced the "network+mail" borrowing process and new barrier-free information exchange equipment such as a book listening machine.

In Hefei Library, the Procuratorate of Shushan District, together with the public welfare organization for the protection of the disabled, also held a forum on the spot with the theme of "helping the disabled with culture and reading the light". During the discussion and exchange, participants in the "Looking Back" fully affirmed the efforts made by the procuratorial organs in helping to protect the reading rights and interests of disabled people, and put forward opinions and suggestions on the optimization of Braille book procurement categories, the compilation of e-books, the improvement of online lending process of Braille books, and the promotion of offline navigation volunteer service. The relevant person in charge of Hefei Library said that according to the suggestions and requirements put forward by everyone, the barrier-free information construction in the library will be continuously improved to ensure that special groups such as visually impaired people can better share the achievements of social and cultural services.

"Now the needs of dyslexic groups such as visually impaired people have new connotations and are more diverse. As a procuratorial organ, it should help this special group to share more colorful cultural products in an equal and timely manner with the power of the rule of law." You Yi said. She also told reporters that in the process of handling a series of public interest litigation cases in the fields of transportation and barrier-free information reading, the public interest litigation department of the hospital found that seven disabled representatives who participated in barrier-free environment experience had difficulties in life, and they were transferred to the court as clues for judicial assistance. Complaint and prosecution department. After investigation and verification, the procuratorate issued them a total of 34,000 yuan in judicial assistance.

On October 18th, this administrative public interest litigation case of visually barrier-free information construction handled by Shushan District Procuratorate was jointly rated as a typical case of public interest litigation of barrier-free environment construction by the Supreme People’s Procuratorate, Ministry of Housing and Urban-Rural Development and China Disabled Persons’ Federation. Chu Zhang

[Text/Caiquan Society & Daoge said that the car is shallow] When the price of domestic cars became more and more "outrageous", smart began to stretch. I still remember that the impression of smart at the beginning of the year was 200,000 exquisite cars. On April 14th, the rejuvenated smart Elves #1 and #3 actually jumped directly from 154,900 yuan and 164,900 yuan, which was really surprising. Among them, the guide price range of smart Genie #1 is 154,900-199,900 yuan, and the price is lowered by 25,000-26,000 yuan compared with the old model; The guide price range of smart Wizard #3 is 164,900-219,900 yuan, and the price is lowered by 36,000-55,000 yuan compared with the old model. The adjustment of price strategy reflects smart’s essential understanding of the current competition in the electric vehicle market in China.

While the product price is more close to the people, smart Elves #1 and #3 have repositioned the two products for the domestic market. According to the market environment and user research, some configurations are optimized in the new version, so as to better meet the actual consumption needs of users. At the same time, smart provides a variety of optional packages for close friends to match freely to meet the individual needs of users.

In order to help close friends have the Elf car as soon as possible, smart also launched multiple exclusive rights of close friends in a limited time, including limited-time optional preferential rights, flexible purchase and gift rights, free rights of special colors, replacement rights, repurchase rights, and delivery of bonus points. At the same time, there are various financial schemes such as "0 down payment" and "limited time and low interest" with the lowest annualized rate of 1.99%. The minimum daily supply is only a cup of milk tea, so that close friends can easily own a new luxury car. In addition, close friends can also enjoy four basic rights and interests, including super-long vehicle warranty, super-long three-power core parts warranty, worry-free one-button road rescue, unlimited traffic of vehicles and machines, which is thoughtful and sincere.

New luxury smart SUV, #1 riding the dust!

As the first global pure electric vehicle of smart brand, smart Elf #1 has been highly praised by the industry media and users for its new luxury aesthetics and excellent handling in different road conditions since its launch. Recently, this car has been delivered in batches in Hong Kong. The volume of orders in the past two months even exceeded the total sales of Porsche in Hong Kong in 2023. Among them, the performance version of BRABUS accounts for more than 90% of the orders, making it a veritable dark horse of the same class in the local sales. This achievement is undoubtedly remarkable for Hong Kong, a highly competitive market with picky consumers’ tastes.

Nowadays, this boutique car that has been riding in many consumer markets has ushered in a new look. In terms of face value, we continue to adopt the design philosophy of "Sensibility and Lingrui" tailored by Mercedes-Benz global design team: light and shadow penetrating front and rear LED headlights, frameless doors and hidden door handles, and "inspiration ring" suspended contrasting roof, which fully demonstrates the new luxury and fashion taste.

In the interior, it inherits the design concept of "compact outside and wide inside", with 20 flexible storage spaces and a minimalist T-shaped intelligent cockpit, creating a high-quality inspiration space for exclusive close friends.

Intelligently, it is equipped with the smart Pilot Assist intelligent driving system and the smart OS full-scene digital eco-car system, so that each elf has a lively and lovely elf assistant Avatar, and users can enjoy the intelligent and comfortable driving experience at any time.

New luxury sports coupe, open the door and see #3!

As the second global masterpiece of smart Elf series, smart Elf #3 has been released and delivered in many markets such as China and Europe, and has become the love of global hipster fans.

Externally, following the design philosophy of "sensibility and agility", smart Genie #3 won the blessing of the global design team of Mercedes-Benz: the avant-garde and dynamic slip-back shape, combined with the organic combination of muscular feeling and life lines, "stealing the mirror".

In terms of interior, the sports car-class low sitting posture, T-shaped smart cockpit with integrated embracing coupe seat and 1.6m2 immersive canopy further enhance the new luxury sports atmosphere owned by Smart Elf #3, which is "true atmosphere".

In addition, smart Genie #3 has the leading dynamic driving performance at the same level, and the dynamic four-wheel drive version is equipped with a dual-motor intelligent four-wheel drive system, which only takes 4.3s to accelerate 100 kilometers. The whole system adopts the former McPherson rear five-link independent suspension, and the sports chassis jointly adjusted by the smart team and the Mercedes-Benz expert team is "driving and controlling the true type".

It is worth mentioning that, at the launch conference of smart Genie #1 and #3, Tong Xiangbei, CEO of smart Brand Global Company, also implicitly poked a certain meter with high popularity recently. He sat in the car for example: this textured rubber made three bulges and hold the cup by the elasticity of the bulges. In this way, it lost eight moving parts compared with us. How much did it cost? Of course, this kind of texture looks like a brand from a distance, but in fact, if you look at this detail carefully, there is no way to see it everywhere.

The implication is that the control of smart cars in details is quite exquisite, which is not the same as that of some brands.

It can be seen that in order to occupy a place in this year’s more involved competition in China electric vehicle market, smart has not only prepared for the price, but also prepared for the product quality control. Smart Elves #1 and #3, which are already famous, will undoubtedly become a strong support for brand sales after price reduction and upgrading.

At the beginning of the year of "global transition", smart will continue to adhere to the core operation concept of "user center", bring new luxury travel and luxury quality to more close friends with a new look, and constantly "explore the best solution for future urban transportation".

Professor Yang Xichuan, Original Professor of Xichuan Xiaoliang Dermatology

| Editing/Typesetting: Fanny Editor: kiki&Jeing Audit: Li Yun

Fact is stranger than fiction. There are thousands of diseases in the world, which are particularly strange and rare?

Today, Xiao Liang, a boy♂ who is keen on studying the mysteries of the body, will take you close to science and learn about four bizarre and rare human diseases that may be unknown to 90% people (strange knowledge has increased again).

Please note that there is continuous high energy ahead, and timid students should be careful ~

NO.1 Shuren disease: hands and feet are covered with "branches and roots"

I’m sure you’ve all heard about vegetative state, but have you ever heard of Shuren? What do you think of first? The cute Groot in Marvel Comics’s movies?

(Source: dribbble/Hancooock)

The tree people in the movie can love each other, but in real life, the "tree people" have to suffer from "tree people’s disease".

Shuren’s disease, medically known as "epidermodysplasia verrucosa", is a rare hereditary skin disease caused by human papillomavirus (HPV) infection, which may be related to gene mutation. It usually begins between the ages of 4 and 8, and most often begins before the age of 20.

People with Shuren’s disease usually grow many sarcomas, maculae and papules that look like branches and roots on their hands and feet, which not only affect the appearance, but also make it inconvenient for daily life, and also turn into skin cancer with high winds.

(Indonesian man suffering from Shuren disease)

Unfortunately, there is no unified and effective solution to this disease at present. Some studies think that retinoids can improve it to some extent. In addition, patients should avoid excessive sun exposure, and if they are prone to cancer, they should be operated immediately or removed by other methods.

NO.2 Premature senility: 7-year-old age and 70-year-old appearance

Anti-aging is the pursuit of many people. Who doesn’t want to be younger and more energetic every year? However, in this world, some people actually get old and even die early at a young age because of a rare genetic disease-premature senility.

Art comes from life. It is said that the film "The Curious Case of Benjamin Button" (also known as "Rejuvenation") may be inspired by premature senility, but the time sequence is reversed. The hero of the film looks like an old man of 70 or 80 at birth. As time goes by, the people around him are getting older, but he is rejuvenating, getting younger and younger, and finally returning to the baby form and dying in the arms of an old lover.

(Source: Movie "The Curious Case of Benjamin Button")

If the protagonist’s life is a bizarre movie, then in reality, patients with premature senility live a life like pressing the acceleration button, aging faster than their peers, feeling the rapid failure of every body organ every day, and dying before they bloom.

There are some heartbreaking facts about premature senility:

● Premature senility in adults: Patients usually develop normally before puberty. At the age of 20-30, they begin to have aging characteristics such as skin wrinkles, muscle atrophy, gray hair and shedding, and the average age of death is 47 years old.

● Premature senility in children: The patient is normal at birth, but after birth, the appearance and body organs will accelerate the aging and decline, and with the increase of age, he will suffer from various diseases such as cardiovascular disease, and the average age of death is only 13 years old.

(patients with premature senility)

NO.3 Vampire: You can only live in darkness.

Legend has it that there are zombies in the East and vampires in the West. Speaking of vampires, you may think of the handsome "ghosts" of noble Leng Yan in film and television dramas. In real life, many people are willing to believe that vampires exist in some corner of the world, but in the medical field, "vampires" really may exist, and they are porphyria patients.

You can slide left and right to view the picture, but it is recommended to slide carefully!

Porphyrin (bD lí n) disease is a rare metabolic disease caused by the lack of enzyme activity in heme biosynthesis pathway, which leads to abnormal increase of porphyrin or its precursor concentration and accumulation in tissues, resulting in cell damage. In 2020, experts in the diagnosis and treatment of porphyria agreed to divide porphyria into the following categories:

(Source: Literature [4])

When the medical profession knew nothing about porphyria hundreds of years ago, patients with porphyria were often considered as legendary vampires, which may be because some symptoms of porphyria are very similar to the image of vampires.

photophobia

People suffering from porphyria will be as afraid to be exposed to the sun as vampires, because they will get sick when they see light, and their skin will have photosensitive reaction, blisters, scars, deformities, etc., and in severe cases, they may be accompanied by the loss of fingers, eyelids, nose and ears.

"bloodthirsty"

Unlike vampires who directly suck people’s necks to drink blood, porphyria patients are "bloodthirsty" by blood transfusion to achieve treatment and relief.

Look different from ordinary people

The high level of porphyrin in red blood cells of patients with porphyria can lead to hemolysis, and severe hemolysis often leads to anemia, so it may cause pallor.

However, people with congenital erythropoietic porphyria will show red or brown color in their teeth, bones and urine due to excessive porphyrin, and they will fluoresce when exposed to ultraviolet rays, which really looks a bit like vampires who have just eaten their children.

NO.4 werewolf syndrome: a real hairy child

Everyone has Mao Mao, but people with werewolf syndrome have a lot of Mao Mao.

However, this werewolf is not a werewolf. The so-called werewolf syndrome actually refers to "congenital systemic hirsutism". The patient’s whole body is covered with thick hair, which is beyond the normal physiological range of the same age, gender and race, and seems to be the image of a werewolf in our impression. In addition to excessive hair, it is usually accompanied by facial deformities.

(Source: Literature [6])

The prevalence rate of werewolf syndrome is extremely low, and it was once considered as an "atavism" phenomenon. However, at present, most studies believe that patients suffer from this disease because of unknown genetic defects.

Patients with the above diseases are often noticed by people in their daily lives because of their abnormal appearance, but who doesn’t want to be healthy and safe in life, and who would like to do so if they could start over.

When you meet them in your life, please be less discriminating and misunderstanding, and more understanding and kindness. I also hope that medical technology will be more developed in the future, so that these special patients can get better treatment and return to ordinary people’s lives.

[References]

[1]Agharbi FZ. Epidermodysplasie verruciforme: à propos d’un cas [Epidermodysplasia verruciformis: about a case]. Pan Afr Med J. 2018 May 29; 30:78. French. doi: 10.11604/pamj.2018.30.78.16058. PMID: 30344862; PMCID: PMC6191268.

Yang Hui, Liu Wan, Chang Jianmin. Verrucous epidermal dysplasia [J]. Journal of Clinical Dermatology, 2015:13-14.

Wang Zehua, Li Hongyu, Qu Jing, Zhang Weiqi, Liu Guanghui. Pathogenesis and intervention methods of human premature senility [J]. Progress in biochemistry and biophysics, 2018,45(09):926-934.

[4] Erythrocyte Disease (Anemia) Group, Hematology Branch, Chinese Medical Association. Expert Consensus on Diagnosis and Treatment of Porphyrin Disease in China (2020) [J]. Chinese Medical Journal, 2020,100 (14): 1051-1056.

[5]Pavone P, Praticò AD, Falsaperla R, Ruggieri M, Zollino M, Corsello G, Neri G. Congenital generalized hypertrichosis: the skin as a clue to complex malformation syndromes. Ital J Pediatr. 2015 Aug 5; 41:55. doi: 10.1186/s13052-015-0161-3. PMID: 26242548; PMCID: PMC4526284.

[6]Sun M, Li N, Dong W, Chen Z, Liu Q, Xu Y, He G, Shi Y, Li X, Hao J, Luo Y, Shang D, Lv D, Ma F, Zhang D, Hua R, Lu C, Wen Y, Cao L, Irvine AD, McLean WH, Dong Q, Wang MR, Yu J, He L, Lo WH, Zhang X. Copy-number mutations on chromosome 17q24.2-q24.3 in congenital generalized hypertrichosis terminalis with or without gingival hyperplasia. Am J Hum Genet. 2009 Jun; 84(6):807-13. doi: 10.1016/j.ajhg.2009.04.018. Epub 2009 May 21. PMID: 19463983; PMCID: PMC2694973.

[disclaimer]

The data in this article was updated on May 14th, 2021.

It was originally written by Professor Yang Xichuan, a dermatologist, aiming at popularizing science for readers.

Popular science content can not replace doctors’ diagnosis and treatment opinions, and is for reference only.

If you have skin problems, please consult a doctor in time.

Some pictures are from the Internet. If there is any infringement, please contact to delete them.

Cover image source: blurrr

Read the original text

Five blind people with special skills are playing cards. Jiang Yuejun

　　Others don’t let their opponents see the cards when they play cards, but they don’t: some of the cards in their hands are facing up and some are facing down, and they always tilt their heads and lean sideways when playing cards, and their hands are constantly pinching the cards, while they are "listening" with rapt attention … This is the scene that the reporter saw five blind people playing cards in Fangjia, Yang Qiu, a villager in Hanyangwang Village, Danyang City yesterday. Yang Qiufang, a blind man, told reporters that they all play cards by "touching" with their hands, "listening" with their ears and "remembering" with their hearts, but the most important thing is to trust each other and never cheat. It is because of this honesty that five blind people get great happiness from it.

　　Special skills are more magical than magic.

　　"Blind people can’t see, how can they play cards?" With curiosity, the reporter came to the home of Yang Qiufang, a blind man in Hanyangwang Village, Houxiang Town, Danyang yesterday morning. As soon as he entered the door, he saw five blind people sitting around playing "four hits one (a local poker game)".

　　The reporter saw at the scene that in order to ensure the speed, a villager was responsible for licensing them, and five blind people were in no hurry, touching them one by one and holding them in their hands. The reporter found that when they got the card, the thumbs of the five blind people touched the top of the card, and then they were sandwiched between five fingers according to the number and color, and the card was smooth, and the speed was not much slower than that of the healthy people.

　　"Three’ 4′ band pairs’ 6′!" A blind man in his 50 s sitting by the door played cards, and another blind man sitting below immediately drew five cards and said, "Three’ K’ s are paired with’ 3’"; "Bomb, four’ 7′!" The blind man by the door brushed the ground and threw out four cards … Although the five blind people couldn’t see the cards thrown out by the other side, they were very quick-witted, and played with relish with the particularly loud shouting. It’s hard to imagine that they couldn’t see at all if they weren’t at the scene.

　　The reporter was puzzled. After obtaining the consent of 76-year-old Ge Yunliang, the reporter took the cards in his hand. The scene in front of him shocked the reporter. The cards were arranged in order of size, and the cards of the same color were neatly put together, which was not chaotic at all. Its magic is comparable to Liu Qian’s magic.

　　A new deck of cards can be mastered in three days.

　　The reporter also touched it with his fingers, feeling that the numbers and colors on the card were not concave and convex at all, not Braille cards, and he couldn’t feel it when he touched it. Closing his eyes was more like touching a piece of paper. How do these five completely blind people "recognize cards"? On what basis can you make a judgment quickly?

　　The reporter asked what the trick was, and they said, tell you, you can’t touch it. Don’t say that you are a normal person, even other blind people can’t touch it. The reporter observed at the scene that with the "deepening" of the game, these blind people gradually got excited, and the speed of playing cards was obviously faster, and occasionally they made mistakes. For example, if you shout "a pair of twos", the cards issued are a two and a three, and the dealer and spectators will remind them in time.

　　In order to verify the skills of five blind people to touch and read cards again, the reporter specially bought a deck of ordinary poker in the supermarket and took it out for them to change cards. Unexpectedly, several people went on as usual, and it was basically accurate. Yang Qiufang also told reporters that this pair of poker bought by reporters is the third-generation "Three Guns" brand, which is more difficult to touch than the first and second generations, because compared with the first and second generations, paper and printing are different, although ordinary people can’t feel it, but in fact there are still very subtle differences in their hands. The numbers and colors on the first and second generations are still slightly concave and convex, while the three generations feel smoother. But as long as you give him three days, they will soon be proficient.

　　reveal a secret

　　Why did you practice this trick?

　　Ink handwriting can be felt.

　　Yang Qiufang, a blind man, told reporters that there are many blind friends around him, but only five of them can play cards, because several of them often study and ponder together, and other blind people don’t have the patience. Of course, this also requires some talent. He told reporters that the youngest of them is only 46 years old. He was sick and blind when he was in high school. He is very smart and can find out the colors in a short time. He said that if normal people calm down and ponder hard, they should also feel this way. Although the concave and convex of the card is very subtle, there are ink marks after all. He told reporters that they can not only touch the cards, but also know the counterfeit money that the money detector can’t identify, and they can also touch the pen words written on the paper. It is said that practice makes perfect.

　　"I can feel what cards are in my hand, but what if others deliberately make mistakes?" When the reporter made this remark, Yang Qiu and his blind friends all laughed and repeatedly said, "We don’t play cards blindly. Although we can’t see it, we have to rely on our consciousness and trust to play cards. Otherwise, how can we fight? Besides, what happiness can we have if we cheat each other? We play cards by heart and play with heart. "

　　The reporter learned in the interview that these five blind people knew each other in their early years, and they have been playing cards together for more than ten years, and occasionally they will get a little reward. In the process of learning card art, "card friends" not only forged a deep friendship, but also enriched their lives. It’s amazing that five people who live completely in the dark can cross the visual barrier and enjoy playing poker together.

Editor: Peng Wei

Dr. Guan Kang Kang You from the Department of Nuclear Medicine talks about thyroid gland.

1. What is pepsinogen?

Pepsinogen (PG) is the precursor of pepsin. According to its biochemical properties and immunogenicity, it can be divided into two subgroups. The immunogenicity of 1~5 components is the same, and it is called Pepsinogen I (PG I), which is mainly secreted by the main cells of gastric fundus gland and mucus neck cells. Components 6 and 7 are called pepsinogen Ⅱ(PGⅡ), which can be secreted by the main cells and mucus neck cells of gastric fundus gland, and also produced by mucus neck cells of pyloric gland of cardiac gland and gastric antrum and upper duodenum.

Usually, about 1% PG enters the blood circulation through the capillary of gastric mucosa, and the PG entering the blood circulation is very stable in the blood. Serum PG ⅰ and PG ⅱ reflect the number of glands and cells in gastric mucosa, and indirectly reflect the secretory function of different parts of gastric mucosa. When pathological changes occur in gastric mucosa, the content of serum PG also changes. Therefore, monitoring the concentration of PG in serum can be used as a means to monitor the status of gastric mucosa.

Detection of pepsinogen (PG), an early warning indicator of gastric cancer

1. Chronic atrophic gastritis is an important "transitional event" in gastric mucosa canceration.

Gastric cancer is one of the common malignant tumors in China, and its mortality ranks first among all kinds of malignant tumors. Its early diagnosis and early treatment have become the only way to improve the quality of life of patients and reduce the mortality. At present, the main methods for diagnosing gastric cancer are fiberoptic gastroscopy and upper gastrointestinal radiography, among which gastroscopy is called the "gold standard" for diagnosing gastric cancer.

At present, it is believed that partial atrophy can be reversed, and once it enters intestinal metaplasia, it is difficult to reverse it. Therefore, there is an urgent need for a tool that can keenly detect the atrophy of gastric mucosa. At this time, the detection of pepsinogen plays a powerful role.

When the gastric fundus gland atrophied, the number of main cells decreased and the level of PG ⅰ decreased. However, because there are more cells secreting PG ⅱ, PG ⅱ can still maintain a high level at this time, and the ratio of PG ⅰ to PG ⅱ decreased significantly. When atrophic gastritis is accompanied by intestinal metaplasia and gastric antrum gland extends to the stomach body, and pseudopyloric metaplasia of gastric fundus gland occurs, the level of PG ⅱ increases more, and the ratio of PG ⅰ to PG ⅱ decreases further. Therefore, the decrease of PG ⅰ level is a reliable sign of gastric fundus gland mucosa atrophy, and PG ⅰ/PG ⅱ profile reflects the degree of gastric fundus gland mucosa atrophy.

2. Helicobacter pylori infection is the initiating factor for the development of gastric cancer.

The occurrence of gastric cancer is the result of multiple factors. The multi-step hypothesis of gastric cancer, that is, from chronic non-atrophic gastritis (formerly known as chronic superficial gastritis) → atrophic gastritis → intestinal metaplasia → intraepithelial neoplasia (formerly known as dysplasia) → gastric cancer, has been generally accepted. Helicobacter pylori (Hp) infection has become the most important initiating factor, and Hp infection has been recognized as an independent risk factor for gastric cancer.

Therefore, active detection of Hp has become one of the important measures to prevent and treat gastric cancer. Hp detection is mainly divided into invasive and non-invasive methods. For Hp-positive infected people, the major guidelines have reached a consensus that Hp infection-related gastritis is an infectious disease and it is recommended to eradicate it.

Hp infection can also significantly affect the serum PG level. At the beginning, PG ⅰ and PG ⅱ both increased, and the increase of PG ⅱ was faster, then PG ⅰ/PG ⅱ decreased, and the larger the Hp infection focus, the greater the decrease of PG ⅰ/PG ⅱ. However, the results of pepsinogen test are lack of specificity, and special Hp test is still needed to judge whether Hp is infected or not.

Third, pepsinogen Ⅰ(PGⅠ),

The results of pepsinogen Ⅱ(PGⅡ) were analyzed as follows:

Four, "pepsinogen" test results misunderstanding:

Myth # 1: If only PG ⅰ is measured during physical examination, nearly 70% of the results are in the range of 40~70ng/mL, which seems to be lower than 70ng/mL on the surface, and gastric atrophy is suspected, but the results are difficult to explain because PG ⅱ and ratio are not measured. When PGⅡ is retested, the ratio of more than 90% is greater than 3. This kind of situation is due to the high incidence of chronic superficial gastritis in China population, which belongs to normal physiological gastric acid secretion insufficiency.

Myth 2: PG-positive means "stomach cancer theory": positive means people at high risk of stomach cancer. PG project is a simple screening project for gastric cancer in the early stage of physical examination, replacing X-ray and ultrasonic screening for gastric cancer. The main significance lies not in diagnosis but in early detection and prevention. Normal people are 15%PG positive, and those with PG positive have a high risk of developing gastric cancer, and the early detection rate of gastric cancer is 1%~2%.

Myth # 3: Pay attention to the change of reference range values of PG ⅰ and PG ⅱ, but not the ratio. Because the secretion of PG ⅰ in gastric mucosa changes greatly (above 70~800ng/mL) under the attack of inflammation, the secretion of PG ⅱ is relatively constant. When comparative value > 3, the degree of PG ⅰ increase can only be combined with clinical analysis to determine the type of gastric diseases. When comparative value < 3, it is suggested that further in-depth endoscopy or pathological sampling should be taken to confirm and warn the high risk of early gastric cancer, and follow-up monitoring should be carried out in the last five years. The incidence of gastric cancer was 2% in PG-positive patients who had no gastric cancer in the same year and in the following five years.

Five, Japan’s experience for reference ("ABC" method+endoscopic screening)

Our neighbor Japan, as a country with high incidence of gastric cancer, has done a very good job in early cancer screening. Their screening strategy for early cancer firmly grasps the two controllable factors of Hp infection and whether gastric fundus gland atrophy occurs.

The Kyoto Consensus of Japan made the following recommendations for the national early cancer screening strategy: first, for Hp infection, the Kyoto Consensus emphasized "shoot to kill", and after everyone sterilized and eradicated Hp, PG was evaluated. The ratio of PG ⅰ/PG ⅱ is ≤3.0, which is regarded as the critical diagnostic value of atrophic gastritis, and as the screening standard of high-risk population of gastric cancer.

Vi. A Long Way to Go-Strategies for Early Cancer Screening in China;

China has a large population base and the incidence of gastric cancer remains high, so it is imperative to find a simple, accurate and effective screening method for gastric cancer. In 2017, the China Consensus on Chronic Gastritis highly affirmed the value of PG, and the guidelines gave the following recommendations: The detection of serum pepsinogen (PG) ⅰ and ⅱ and gastrin -17 may help to judge whether there is gastric mucosal atrophy and its degree. Detection of serum PG ⅰ, PG ⅱ, PG ⅰ/PG ⅱ ratio combined with anti-Hp antibody is helpful for risk stratification management.

The Expert Consensus on Early Gastric Cancer Screening Process in China, published at the end of 2017, not only affirmed the value of serum PG, but also put forward a new gastric cancer screening scoring system, in which the elderly, male, Hp antibody positive, low pepsinogen ratio (PGR) and high serum 17(gastrin-17 (G-17) level are high risk factors for gastric cancer.

Among them, G-17 is a new item in China Guide. G-17 is an amidated gastrin synthesized and secreted by G cells in gastric antrum. Its main physiological function is to stimulate gastric acid secretion and promote the proliferation and differentiation of gastric mucosal cells. G-17 is one of the sensitive indexes to reflect the endocrine function of gastric antrum, which can indicate the atrophy of gastric antrum mucosa or whether there is abnormal proliferation. G-17 itself can also promote the occurrence and development of gastric cancer. When the serum G-17 level rises, it may indicate the risk of gastric cancer.

In addition, different from the Kyoto consensus, the consensus in China put forward the critical value of serological detection for the first time, that is, when PGR<3.89 and G-17> 1.50pmol/L, the risk of gastric cancer increased significantly. The critical value of PGR defined by Kyoto Consensus is ≤3.

According to the score, the guide divides the population into three groups: low risk, medium risk and high risk, and gives the screening strategy.

At the same time, however, we should also see the shortcomings of the China guidelines. The screening population is over 40 years old, and there are other risk factors such as high incidence area of gastric cancer, Hp infection, previous precancerous diseases of gastric cancer, first-degree relatives of gastric cancer patients, diet and so on. However, at present, the onset age of gastric cancer is getting earlier and earlier, and I believe it will definitely enter prospecting stage in the future.

To sum up, serum PG combined with Hp detection is helpful to evaluate the risk of gastric cancer, and can be used as a routine screening method for gastric cancer for ordinary people. However, it cannot replace gastroscopy, and gastroscopy is still strongly recommended for high-risk groups.

Original title: Clinical Significance of Detection of Pepsinogen (PG)

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News from The Paper, Hebei, one of Gree Electric’s important markets, has suffered an unexpected change just as air-conditioning enterprises are preparing for the new freezing year.

It is reported that Hebei Xinxing Gree Electric Sales Co., Ltd. (Hebei Gree), a distributor in Gree Electric, issued a notice on August 18th, saying that on August 16th, Gree Electric suddenly stopped the delivery of goods to Hebei Gree, and asked the distributors who had invested money to plan and pick up the goods as soon as possible.

Just four days after Gree Electric cut off the supply of Gree in Hebei, on August 20th, Xu Zifa, the chairman of Hebei Xinxing Gree Electric Sales Co., Ltd., hosted a banquet for the mainstream distributors in Shijiazhuang five-star hotel, and announced at the meeting that he would quit the operation of Gree from today! At the same time, he promised to give everyone a reassurance, and the dealer’s payment, rebate and anwei fee will be cashed for everyone.

According to a reporter from The Paper who learned from an insider, the details of "Moutai that was drunk for 15 years that night, and 100,000 cash was distributed to 10 people at each table" were true. Xu Zifa also thanked the dealer for his support for so many years.

On August 23rd, a reporter from The Paper called Hebei Gree, and the staff who answered the phone said "there is no obligation to answer whether the company will continue to sell Gree air conditioners" and "if you want to buy Gree air conditioners, the market is everywhere".

Gree Electric also chose to play it cool. As of press time in The Paper, Gree Electric has not responded positively to this matter.

However, The Paper reporter learned from a number of people in the home appliance industry that Gree Electric really fell out with Hebei Gree. Next, Gree Electric will re-establish distribution channels in Hebei.

Some media reported that after Gree stopped supplying to the general distributor in Hebei, Gree Zhuhai Headquarters sent a 50-member marketing team to Hebei, bypassing the original general distribution of Gree in Hebei and contacting local agents. The Paper reporter also learned from insiders that the situation is basically true.

The strength of Hebei Gree should not be underestimated.

Hebei Xinxing Gree Electric Sales Co., Ltd. is one of the most powerful distributors in Gree Electric. Jinghai Internet Technology Development Co., Ltd. (Jinghai Internet), which was established by Hebei Gree and more than a dozen Gree Electric distributors, is an important shareholder of Gree Electric. As of the first quarter of this year, Jinghai Internet holds 8.34% of the shares of Gree Electric, ranking the third largest shareholder.

Tianyancha information shows that Hebei Gree indirectly holds 28% of the shareholders of Jinghai Internet and is also the largest shareholder of Jinghai Internet.

However, on June 24th this year, Gree Electric announced that it had received the Notice of Share Reduction from Jinghai Internet, a shareholder holding more than 5% of the shares. On June 24th, 2022, Jinghai Internet reduced its shareholding by 110,219,217 shares, accounting for 1.86% of the total share capital of Gree Electric, and cashed in 3.5 billion yuan. After the reduction, the shareholding ratio of Jinghai Internet decreased to 6.47%.

More importantly, as a major distributor in Gree Electric, Xu Zifa is also an investor in Philips Air Conditioning, which may also be one of the reasons for the deadlock between the two sides.

On August 9th this year, at the new product launch conference held by Philips Air Conditioning, Huang Hui, the former CEO of Gree Electric, appeared as the chairman of Philips Air Conditioning, Vinfom Hu, the assistant to the former president of Gree Electric, became the president of Philips Air Conditioning, and Xu Zifa attended the meeting as the shareholder representative of Philips Air Conditioning.

Gree turned into a competitor of Gree, which obviously angered Gree.

Liu Buchen, a senior home appliance observer, said in an interview with a reporter from The Paper that Gree Electric must be very dissatisfied with this practice of Hebei Gree. Before that, Gree Electric asked the dealer to choose one, and if he wanted to represent Gree, he could not represent Philips.

"Hebei Gree has both active and passive factors in doing so. Passive factors Gree Electric has promoted channel transformation in recent years, and the proportion of online sales has become higher and higher, which has affected the interests of traditional dealers and forced them to seek new ways out; However, investing in Philips is definitely the initiative of Hebei Gree. Considering so many years of experience and resources, I will try Philips air conditioning. " Liu Buchen said that he is not optimistic about the future prospects of Philips Air Conditioning and will not pose a threat to Gree.

However, Liu Buchen believes that it will take time for Gree to change the Hebei channel and find a suitable candidate, which may have a negative impact on Gree’s local sales.

However, the Hebei dealer incident did not bring much pressure to Gree Electric’s share price. On August 23rd, Gree Electric closed at 30.23 yuan, a decrease of 0.85%. The total market value of Gree Electric is 170.2 billion yuan.

Original title: Drink Maotai and discover gold! Xu Zifa took the lead in Hebei dealers and announced that he would quit Gree and went to Philips.

　　Famous Director & Actor Ying Da:It is impossible to judge the quality of comedy reality show according to a standard. I laugh when I can laugh. I think the level of domestic comedies is comparable to that of foreign comedies at this stage, because there are no sitcoms in China and cross talk in foreign countries. All the good comedies in foreign countries are in sitcoms, while the better comedies in China are kept in cross talk, and there is almost no second form. The skits are not at all. The farce is a new kind of drama and there is no chance.

　　

　　Liu Jianli, producer of Hunan Satellite TV’s "We All Love to Laugh":In fact, we can’t strictly define comedy, but no matter how the form of comedy changes, its core remains the same, that is, how to amuse the audience. I think it is most important to amuse the audience, whether it is the traditional comedy mode or the innovative performance form. At present, there is no complete training model for comedy talents in China. But as far as our program is concerned, the cultivation of talents is divided into two parts: external force and internal brain. External force is to learn from the mature experience of developed countries and carry out professional training; The inner brain means that in the process of making a program, the director and staff will sum up their own experiences in order to perform better.

　　

　　Famous crosstalk actor Degang Guo:It is said that crosstalk is within the scope of comedy, and comedy is still related to my major. My ability is average, but I can make do with it. I can still complete the task as a tutor.

　　

　　Song Weicai, Associate Professor, School of Art and Media, Beijing Normal University:The phenomenon that China variety shows follow the trend and rush headlong into action has a long history. However, the audience of the programs with the same theme may only pay attention to two or three files, and most of the follow-up works will soon disappear. Compared with music talent shows, comedy shows are actually more difficult to do, and it is more difficult for the market to support multiple programs, because in addition to players and tutors, it must also have enough original works. A newly created song can be sung many times and by different singers on different occasions. Once a comedy "Bao" is used once, it is difficult to use it in other comedies. This requires that these comedy columns or all kinds of comedy creative teams supporting these columns must have strong program originality, which is what the literary and art circles lack most at present. The lack of language programs in the Spring Festival Evening of the Year of the Horse is the most direct manifestation of this lack of originality.

　

　　Netizen Ameng:If China TV variety shows don’t make efforts to eradicate this homogeneity and change this morbid prosperity and vicious competition, they will eventually become monotonous and exhausted, which will only disgust the audience and lose their support.

　

　　China Economic Net Xiaobian has something to say:This round of comedy variety shows is also striving for dislocation competition. For example, some programs are more professional, while others mainly build grassroots players. Some of them are mainly complete comedies, while others are small performances of tens of seconds. However, the pressure of audience competition and the lack of innovation ability have made various TV stations afraid to take risks on the theme. The homogenization of China TV variety shows has not changed at all in this round of comedy trend.

　　CCTV News:According to the website of China Banking and Insurance Regulatory Commission, China, recently, the Consumer Protection Bureau of China Banking and Insurance Regulatory Commission, China issued the Notice on the Complaints about Insurance Consumption in the Second Quarter of 2022 (No.11 Notice of 2022, hereinafter referred to as the Notice), which informed the complaints about insurance consumption received and transmitted by China Banking and Insurance Regulatory Commission and its dispatched offices.

　　According to the Circular, China Banking and Insurance Regulatory Commission and its agencies received and forwarded 28,554 complaints about insurance consumption in the second quarter. Among them, 10051 property insurance companies were involved, accounting for 35.20% of the total complaints; There were 18,503 life insurance companies, accounting for 64.80% of the total complaints. The number of complaints from PICC P&C ranks first among property insurance companies. The number of complaints in Ping An Life Insurance Company of China ranks first among life insurance companies.

　　According to the Circular, in the second quarter of 2022, the median number of complaints about 100 million yuan premium of property insurance companies was 3.58 pieces/100 million yuan, and the median number of complaints about 10,000 policies was 0.36 pieces/10,000 pieces; The median number of complaints about 100 million yuan premium of life insurance companies is 1.78/100 million yuan, the median number of complaints about 10,000 policies is 0.25/10,000, and the median number of complaints about 10,000 people is 0.08/10,000. Zhonghui Mutual Insurance ranks first among property insurance companies in terms of the complaints about the 100 million yuan premium. The number of complaints about 10,000 policies of Jiulong Property Insurance and Zhonghui Mutual Insurance ranks in the top two among property insurance companies. Fosun United Health ranks first among life insurance companies in terms of complaints about 100 million yuan premium, complaints about 10,000 policies and complaints about 10,000 people.

　　According to the Circular, in the second quarter of 2022, there were 7,808 complaints about claims disputes involving property insurance companies, accounting for 77.68% of the total complaints of property insurance companies; There were 822 complaints about sales disputes, accounting for 8.18%. Zhonghui Mutual Insurance, PICC P&C Insurance and Zhongan Online P&C Insurance rank among the top three property insurance companies. PICC P&C Insurance and Ping An P&C Insurance rank in the top two among property insurance companies.

　　In the second quarter of 2022, property insurance companies filed 4324 complaints about motor vehicle insurance disputes, accounting for 43.02% of the total complaints of property insurance companies; There were 2,434 complaints about other insurance disputes involving property insurance such as COVID-19 epidemic isolation insurance, accounting for 24.22%. PICC P&C ranked first among property insurance companies in the number of complaints about motor vehicle insurance disputes. Zhonghui Mutual Insurance and Zhongan Online Property Insurance are among the top two property insurance companies in terms of complaints about property insurance related to COVID-19 epidemic isolation and other insurance disputes.

　　According to the Circular, in the second quarter of 2022, there were 9,613 complaints about sales disputes from life insurance companies, accounting for 51.95% of the total complaints from life insurance companies. There were 5011 complaints about surrender disputes, accounting for 27.08%. The number of complaints about sales disputes and surrender disputes in Ping An Life Insurance Company of China ranks first among life insurance companies.

　　In the second quarter of 2022, there were 8101 complaints about ordinary life insurance disputes from life insurance companies, accounting for 43.78% of the total complaints from life insurance companies; There were 4182 complaints about sickness insurance disputes, accounting for 22.60%. The number of complaints about ordinary life insurance disputes in Ping An Life Insurance Company of China ranks first among life insurance companies. Ping An Life Insurance Company of China and Xinhua Life Insurance ranked the top two in terms of complaints about sickness insurance disputes among life insurance companies.

Ashton Kutcher, the American movie star who plays Jobs, has just joined Lenovo Group. According to the USA-Today website, Kucher signed a cooperation agreement with Lenovo on the evening of 29th local time to serve as Lenovo’s product engineer and spokesperson.

Lenovo held a new product launch conference in Los Angeles at 7 o’clock that night, and launched the world’s first "legged" tablet computer &mdash; &mdash; Yoga tablet. The conference was broadcast live on Youtube for global users to watch. At the press conference, Kucher held a Yoga tablet computer, just like the way Jobs introduced Apple’s new products. After the conference, Kucher will meet Lenovo engineers and executives in China in the future.

Kucher introduces Lenovo Yoga tablet computer.

Kucher said at the press conference that modern people often encounter two situations in their daily lives: lying in bed and using a tablet computer is easy to slip into their face because of their hands; The battery of a tablet or smart phone is useless, so everyone has to bring a brick-like mobile power supply. These two common details made the audience laugh, which is indeed an experience that many people have had. The new products launched by Lenovo just solved these two problems: the small bracket liberated people’s hands; The battery life that can work continuously for 18 hours on a single charge can help people reduce the weight of their backpacks. In addition, you can also charge your smartphone with a tablet computer, and the USB interface on the tablet computer can easily achieve this.

Lenovo’s new tablet has 8-inch and 10-inch versions, and the price is $249 and $299 respectively. These two products will be available from October 30, just in time to "play against Taiwan" with the Apple tablet iPad Air, which was officially released on November 1. However, Lenovo’s products are much cheaper than Apple’s iPad Air, and the lowest price of the new generation iPad is $499.

Kucher, 35, graduated from the University of Iowa in the United States, majoring in biochemical engineering (but didn’t graduate). She was once kicked out of her dormitory because she was too noisy and crazy. However, he is now Walden Schmidt, the hero of the popular comedy Two and a Half Heroes, which was launched by CBS in the United States, and also a famous angel investor in Silicon Valley. In addition to Skype, Kucher’s investment also includes Foursquare, Flipboard and Path.

Kucher at the new product launch is very much like Jobs.

Kucher has also cooperated with Google and Apple. When talking about why he joined Lenovo, Kucher said, "Lenovo’s hardware is very, very good. I want to make their products as consumer-friendly as possible. " Kucher will make suggestions on the design and software of Yoga tablet.

USA-Today said that this cooperation is a prepared risk for both sides. And Kucher said that this is precisely the reason why he joined Lenovo. "If you look back on my career, you will find that I have always liked adventure &mdash; &mdash; Lenovo, too, "Kucher said.

Phoenix. com said that some fruit fans commented that Kucher had joined Lenovo: He should know more about Apple culture after playing Jobs, and now it’s a bit disappointing to advertise Lenovo for money. It seems that he is not a real fruit fan. Since he is not a fruit fan, no wonder he can’t play Jobs well.

Lenovo and Kucher did not disclose the salary of this cooperation.

Stills of the movie Jobs