On April 18th, Chery started the pre-sale, and the new car launched a total of four configuration models, with the pre-sale price range of 159,900 to 199,900 yuan. Fengyun T9 positioned a compact SUV equipped with Chery C-DM hybrid system.

At the pre-sale conference, the official said that 9.9 yuan can participate in crowdfunding or lottery if it orders. When the total order volume is less than 10,000, the listing price will be reduced by 5,000 yuan, and so on, the highest price will be reduced by 20,000 yuan.

Fengyun series is a brand-new energy sequence of Chery brand, which was officially released in November last year. At the same time, it will adopt a brand-new product Logo, and it will launch 11 brand-new models in the next two years, based on Chery Kunpeng’s super C-DM hybrid technology.

Under Chery’s new energy brand system, there are currently four new energy brands: Chery New Energy, Jietu, Xingtu and iCAR, and the Fengyun sequence in Chery New Energy has been restarted into a hybrid brand, and Xingtu’s Star Era is defined as the high-end brand of Chery New Energy.

Fengyun T9 Appearance & Interior Appreciation

As Chery’s brand-new energy sequence, we feel a strong "new energy smell" from its front face design. The front face of the new car adopts a large-area closed grille, but the traditional grille position still adds matte silver trim strips to outline the shape, which is very aura as a whole, while the air inlet for the engine is hidden under the front face.

Coming to the side of the car body, Fengyun T9 uses privacy glass in the back row, and there are not too many complicated lines in the whole car body. The shape of the traditional SUV benefits from the size and also shows its gas field.

The detailed design part, now hidden door handles, large-size wheels and so on have been given.

In terms of body size, the length, width and height of the new car are 4820X1930X1710mm and the wheelbase is 2820 mm.

The shape of the tail echoes the front face, adopting the design of penetrating taillights, with Chery’s LOGO in the center, and the whole tail seems to have a wide horizontal vision.

In terms of interior, Fengyun T9′ s style is also consistent with the current mainstream. In the center console of the car, there is a large-size floating screen with an estimated size of 15.6 inches, and it is expected to be equipped with Qualcomm Snapdragon 8155 chip, which will bring high vehicle performance and look forward to the subsequent static performance experience.

The main driving instrument also uses a separate floating screen with an estimated size of 10.25 inches.

Other features include zero-gravity seats, wireless charging function of large wattage mobile phones, ventilation, massage and heating of front and rear seats, and other comfort configurations.

In terms of power, Fengyun T9 this time is a hybrid model, with Kunpeng power, 1.5T engine, 3DHT gearbox and CDC suspension system. There will be two versions of two-wheel drive and four-wheel drive. The maximum power of the two-wheel drive motor is 165kW, and that of the four-wheel drive motor is 340kW.

In terms of battery life, the two-wheel drive CLTC has a pure battery life of 160km, and the four-wheel drive version is 150km；; The comprehensive mileage of two-wheel drive and four-wheel drive is 1320km/1100km, respectively, and the power loss and fuel consumption are 5.7L/100km.

C-DM hybrid system

At present, Chery is fully turning to new energy sources, and the hybrid field relies on the Kunpeng super-performance electric hybrid-C-DM independently developed by Chery, equipped with the fifth-generation ACTECO 1.5TGDI high-efficiency hybrid special engine and the third-speed super-electric hybrid DHT.

Under this platform, it can cover a variety of vehicles and power combinations, including A-B cars, SUVs and MPVs, 5-seat, 6-seat and 7-seat vehicles. In terms of power, it covers 1.5T, 2.0T and 1.5L hybrid special engines, as well as 13DHT and 3 DTH hybrid boxes with different power and torque.

Among them, the fifth-generation hybrid engine is the latest achievement of Chery in the hybrid field, and it has the technical applications of Miller Cycle technology, 4.0i-HEC fourth-generation intelligent combustion system, HTC high-efficiency supercharger, i-LS intelligent lubrication system, i-HTM intelligent thermal management system, HiDS high dilution system and so on.

The power system can achieve the maximum effective thermal efficiency of 44.5%, fuel consumption of 4.2L per 100 kilometers and maximum power of 115kW.

In the aspect of hybrid DHT gearbox, three-speed super electric hybrid DHT and stepless super hybrid DHT are also built. Among them, the three-speed super electric hybrid DHT is based on dual-motor drive and three-speed DHT, which has the characteristics of the highest transmission efficiency of 97.6%, acceleration of 4.26s per 100 kilometers, and torque distribution before and after 0-100%.

The stepless super hybrid DHT also realizes the driving state of non-inductive variable speed through E-CVT, and also has the characteristics of pure electro-acoustic pressure level and average efficiency of 90%.

Long battery life is still popular.

The recently announced new energy penetration rate seems to have exceeded 50%, among which the sales of plug-in and extended-range vehicles with large batteries have performed well. From the perspective of car scenes, most car scenes in the city can use pure electricity and long-distance car oil without worrying about energy replenishment, which has become the mainstream car choice for domestic users.

Nowadays, the pure electric life of the vehicle is basically the same as the extended range, and there is no difference in experience. Therefore, the demand for such vehicles is still strong and will gradually replace the pure fuel vehicles. Just like Chery, it will launch 11 new plug-in models in the next two years, which shows that it has been accumulating power for a long time.

1905 movie network news On January 28th, the film directed and starring released the preview and poster, which was officially finalized on February 12th (New Year’s Day) and will be launched on the video platform. In the finalized poster released this time, Wang Baoqiang incarnates as a Shaolin monk, with a face full of righteousness and condensed the soul of Shaolin.

In the trailer, we not only narrate the journey of this filming dream, but also return to Shaolin disciple status to make great efforts. The film shows the pure retro kung fu temperament, which is expected to drive a new wave of family watching movies.

"The strongest dreamer" Wang Baoqiang filmed Shaolin after 30 years.

In the poster released by the film The Legend of Shaolin Temple this time, under the background of gilded texture, the three scarlet characters of "Shaolin Temple" are full of vigor and vitality, which embodies the antique and vigorous Shaolin charm. In Chinese characters, Wang Baoqiang incarnates as a Shaolin monk. The golden rooster is independent and stands upright, just like a golden pine, and punches sideways, which fully shows the martial arts cultivation of Shaolin disciples.

It is reported that this poster is a tribute to the classic kung fu film starring. In the notice released in the same period, Wang Baoqiang claimed that the idea of making this film had already been planted 30 years ago. At the age of eight, the open-air screening of Shaolin Temple in the village made him determined to study martial arts in Shaolin and make a movie. The actor’s dream has been realized for 30 years, but the dream of "making a Shaolin movie" has always called him in his heart.

In the second half of the preview, in the voice-over of "You are a descendant of Shaolin", the role in Wang Baoqiang’s film officially appeared. He not only practiced the five unique skills of the whole knife, gun, sword, stick and cudgel, but also stayed in the countryside and did not forget to realize the true meaning of Shaolin during hard training. No matter in the secular world or Zen family, he was open to the world with his "Shaolin martial spirit" and showed his true colors.

It can be said that, from a grassroots background, to a well-known actor with high nationality, and now, together with Tang Jili, the director of the gold medal action film, he made a dream of Shaolin, Wang Baoqiang fully explained what is the "strongest dreamer". The Legend of Shaolin Temple, which was filmed with such sincere and valuable sincerity, is worth the audience’s expectation.

Jin Dao Shao Lin’s true colors and pure kung fu movies

In recent years, Wang Baoqiang has successfully performed many impressive comedy roles in a series of acclaimed and popular commercial blockbusters, such as "A Man on a Long Road", and has become a "Happy Harvester" that makes the audience feel more cordial. However, in the preview, he changed his old image and became an orthodox Shaolin monk. His posture was solid and steady, his movements were powerful, and his martial arts skills reached the point where he completely subverted everyone’s previous stereotype of him as a "comedian", showing the true nature of Shaolin disciples and his solid martial arts skills.

It is worth mentioning that, with the classic singing of Shaolin Shaolin, Wang Baoqiang skillfully wields swords and sticks, practices hard in spring, summer, autumn and winter, and meditates and realizes the righteousness of the people, which has the charm of the Jet Li version of Shaolin Temple. It is precisely because the film shows the rare pure "retro martial arts film" temperament in today’s era that it can not only hook up the beautiful nostalgic memories of a generation of "martial arts films", but also make the new generation of viewers experience the pure pleasure of action films, so it is very suitable for men, women and children to watch in the same room.

　　According to the website of the General Administration of Market Supervision, recently, the General Administration of Market Supervision issued Announcement No.32 in 2022, approving the promulgation and implementation of 24 national metrology technical specifications such as Verification Regulation of Liquid Piston Pressure Gauges.　

　　In the field of radio metrology, JJF 1286— 2022 "Calibration Specification for Wireless Channel Simulator" focuses on revising the calibration methods of path delay and path loss, increasing the calibration of maximum Doppler frequency shift, and providing technical basis for the calibration of wireless channel simulators in aerospace and aviation industries. Revised and released JJF 1982— 2022 《 Level Oscillator Calibration Specification 》, the upper frequency limit of test signal is extended to 150MHz, and the output impedance is also extended. In the calibration method, both the new digital indicating level oscillator and the traditional pointer level oscillator are taken into account. Revised and released JJF 1238— In 2022, in order to adapt to the changes of relevant international test standards, the calibration of discharge waveform of machine model and latch model was added, and the calibration method of integrated circuit electrostatic discharge test equipment was improved. Formulate and issue JJF 1983— 2022 "Calibration Specification for High-definition Video Signal Analyzer", the high-definition video signal analyzer is a special test instrument for standard compliance test and conformity inspection of high-definition video equipment and video terminal equipment, which is widely used by high-definition video equipment manufacturers and quality inspection institutions. The formulation and release of this specification provides metrological technical support for the development of high-definition video industry.　

　　In the field of pressure measurement, JJG 59— 2022 Verification Regulation of Liquid Piston Pressure Gauge redefines the measurement range and accuracy grade, puts forward the verification requirements of pressure deformation coefficient, clarifies the actual measurement of gravity acceleration, and improves the verification methods and technical indicators. Revised and released JJG 241— 2022 Verification Regulation of Precision Cup-shaped and U-shaped Liquid Pressure Gauges, which is widely used in precision machining, pressure (leakage rate) measurement in aerospace industry, leakage research and other fields, this revision has improved the technical index requirements of some standards used in accuracy grade verification. Formulate and issue JJF 1986— 2022 "Calibration Specification for Differential Pressure Air-tight Leak Detector" clearly stipulates the calibration items, calibration methods and standard selection of this kind of instrument. The calibration items cover the main measurement performance, and the calibration methods are close to the actual working state of the instrument. Formulate and issue JJF 1987— 2022 "Calibration Specification for Air Data Testers" changes the current situation that there is no calibration specification for this type of instruments in China, improves the measurement ability of flight parameters of aviation aircraft, reduces the probability of aviation accident symptoms, improves the dispatch rate and attendance rate of airlines, and serves to ensure the civil aviation transportation industry.　

　　In the field of temperature measurement, JJF 1991— 2022 Calibration Specification for Short Low-cost Metal Thermocouples, which are widely used in aerospace, petrochemical and other fields, are commonly used temperature sensors. The specification mainly includes measurement characteristics, calibration conditions, calibration items, calibration methods and examples of measurement uncertainty evaluation, which provides technical basis for the calibration of short-type cheap metal thermocouples.　

　　In the field of optical metrology, JJF 1988— 2022 Calibration Specification for Communication Signal Analyzer, which is used to test the performance indexes of optical transmitter and pluggable optical transceiver module in optical communication system. The formulation and publication of this specification create favorable conditions for effectively carrying out the traceability of values. Formulate and issue JJF 1989— 2022 "Calibration Specification for Spectral Illuminator" clarifies the measurement characteristics, calibration conditions and calibration methods of spectral illuminators, supports the quality inspection of electric light source products, and promotes the high-quality development of electric light source, display and other industries. Formulate and issue JJF 1990— 2022 "Calibration Specification for Integrating Sphere Standard Light Source", integrating sphere standard light source is a common instrument for calibrating spectral radiometers, luminance meters and area array detectors. The formulation and publication of this specification effectively guarantees the accuracy and reliability of spectral radiation, luminosity and chromaticity in related fields.　

　　In the field of electromagnetic metrology, JJG 126— 2022 Verification Regulation of Power Frequency AC Electric Quantity Measuring Transmitter, this revision improves the applicability of the regulation, solves the problem of value transmission of new digital output transmitter, and helps to ensure the safe operation in smart cities, intelligent manufacturing, automatic control and other fields. Revised and released JJG 982— 2022 Verification Regulation of DC Resistance Box, this revision broadens the scope of application, adjusts the annual stability assessment scope, simplifies the verification method of switch variation, highlights the scientificity, rationality and applicability of verification items and methods, and improves the verification efficiency while ensuring the accuracy and reliability of verification conclusions. Formulate and issue JJG 1186— 2022 Verification Regulation of Verification Device of DC Watt-hour Meter, DC Watt-hour Meter Verification Device, as an important testing equipment of DC Watt-hour Meter, is directly related to the accuracy and reliability of DC energy measurement. The formulation and publication of this specification provides a basis for the verification of DC Watt-hour Meter Verification Device and provides technical support for DC energy measurement in electric vehicles, solar power generation and other fields. Formulate and issue JJF 1985— 2022 "Calibration Specification for Welding Power Supply of DC Electric Welding Machine", the welding power supply of DC electric welding machine is a device that provides output characteristics, and the accuracy of its measurement characteristics directly affects the quality of welding products. The formulation and publication of this specification plays a positive role in improving the quality of welding products and ensuring the safety of related personnel and property.　

　　In the field of high voltage measurement, JJF 1995— 2022 Calibration Specification for Electronic Transformer Calibrator, the electronic transformer calibrator is a special instrument for calibrating electronic transformers, which is widely used by transformer manufacturers and power grid construction units. The formulation and publication of this specification has solved the long-standing problem of the lack of unified traceability method for digital values of electronic transformers, further supported the inspection and testing of electronic transformer products, and provided measurement guarantee for the construction of new power systems.　

　　In the field of time and frequency measurement, JJG 601— 2022 "Verification Regulation of Time Verification Instrument", time verification instrument is a multifunctional and comprehensive time verification equipment. This revision provides a more scientific and reasonable technical basis, thus ensuring the accuracy and reliability of time-frequency working measuring instruments. Revised and released JJF 1984— 2022 "Calibration Specification for Quartz Crystal Oscillators in Electronic Measuring Instruments", quartz crystal oscillators are generally used as the frequency source for generating signals in electronic measuring instruments. This revision proposes calibration methods for measuring characteristics such as relative frequency deviation and frequency stability, which provides scientific and standardized test basis for quartz crystal oscillators in electronic measuring instruments and ensures accurate and reliable transmission of frequency values.　

　　In the field of meteorological metrology, JJF 1992— 2022 "Calibration Specification for Long-wave Radiation Meter" calibrates the measurement characteristics such as the sensitivity of analog output long-wave radiation meter and the correction coefficient of digital output long-wave radiation meter, thus effectively ensuring the accurate measurement of long-wave radiation and net total radiation. The formulation and publication of this specification provides a scientific and unified basis for the traceability and performance evaluation of long-wave radiation meters.　

　　In the field of energy measurement, JJF 1993— 2022 Technical Specification for Energy Measurement of Natural Gas, energy measurement is the main way of international natural gas trade handover, which is fully integrated with national standards. According to three different ways of calorific value determination (online determination, offline determination and assignment), the uncertainty calculation method of natural gas energy is given. This specification can be used as the basis for the evaluation and acceptance of natural gas energy metering system by metering technology institutions and the supervision and inspection by government departments, and can also be used as a reference for energy metering management of users such as oil and gas companies.　

　　In the field of energy efficiency measurement, JJF 1994— 2022 Calibration Specification for Energy Efficiency (Performance) Measuring Devices of Refrigerators, JJF 1261.27— 2022 Rules for Measuring and Testing Projector Energy Efficiency, revised and released JJF 1261.6— 2022 Rules for Measuring and Testing Energy Efficiency of Computer Monitors. The energy efficiency (performance) measuring device for refrigerators is the main measuring equipment for refrigerator performance parameters. The formulation and publication of this specification will accelerate the realization of accurate and consistent measurement data between testing institutions and production enterprises, and play a positive role in standardizing the labeling of energy efficiency labels for refrigerator products and even the development of refrigerator industry. Projectors and computer monitors are widely used as office and learning equipment, which is of great significance for energy saving. This revision includes the measurement requirements, testing conditions, testing items and methods, testing results evaluation criteria, testing reports and other contents of energy efficiency of related products. While guiding consumers to buy energy-efficient products, it encourages manufacturers to increase research and development efforts and enhance consumers’ experience.　

　　The above 24 national metrology technical specifications were formally implemented on March 26th, 2023.　

　　　　　　 CCTV News:From April 11th, Guangdong ushered in the longest and strongest heavy rainfall process since the flood season.

　　　　　　 The reporter learned from the Shenzhen Emergency Management Bureau that at present, five people have died and six people have lost contact due to the flood caused by the rainstorm in Shenzhen. Among them, four river construction workers in Futian District were washed away, and emergency rescue was started immediately after receiving the report. At around 23 o’clock last night, a worker who was washed away was rescued at the Fengtang estuary sluice and sent to the hospital for treatment. His mental state and physical condition were generally good. As of 8: 15 this morning, rescuers found a body in the river. The reporter learned at the press conference in Futian District at 10: 00 am that the identity of the victim has been verified as a previously lost worker. At present, there are still two workers who have lost contact and the rescue continues. In addition, seven people were washed away at the construction site of the West Lake Hotel in Luohu District, and four people were rescued after rescue, one died and two people lost contact; Five people were washed away at the construction site of the East Lake Park section, and three people were confirmed dead and two people lost contact.

　　　　　　 Yesterday (April 11th) at 8 o’clock in the evening, strong convective weather affected Shenzhen. The Shenzhen Meteorological Observatory issued rainstorm yellow, gale yellow and lightning warning signals. At the same time, it also issued the fifth hail warning in the history of Shenzhen. Hail started in Baoan District and Guangming District, and there were short-term rainstorms in many areas.

　　　　　　 Since 9 o’clock last night, heavy rains have also suddenly fallen in Futian, Luohu and other areas in Shenzhen. Water accumulated in several sections for a short time, and the deepest part was about 30 mm. Many cars on the road chose to stop driving and dared not wade through. Until 10: 15 pm, the yellow warning of hail in Shenzhen was cancelled; At 11: 15, rainstorm yellow and gale yellow were also cancelled at the same time, and the strong convective weather ended. Shenzhen Sanfang Office said that relevant emergency plans have been started since 8: 00 last night.

　　　　　　 From the day of April 11th, Qingyuan in northern Guangdong took the lead in heavy rainfall. In the afternoon, there were strong convective weather processes from west to east in all parts of the Pearl River Delta. "Guangdong Weather" official Weibo issued hail, strong wind and lightning weather in northern Guangzhou, and Zengcheng District issued an orange warning of hail and a Class II emergency response to strong convection at 4 pm. Guangzhou Tianhe, Yuexiu and other places have successively issued orange rainstorm warnings. Within an hour, more than 50 mm of precipitation has occurred in Liwan District, and many roads in Guangzhou have been flooded to varying degrees.

　　　　　　 Today, heavy rainfall continued in Guangdong province. Zhanjiang, Gaozhou and other places upgraded the rainstorm warning from yellow to orange at around 8: 00. As of 9: 00 in the morning, 51 counties and cities in Guangdong issued rainstorm warnings and 40 counties and cities issued thunderstorm and gale warnings.

　　　　　　 It is predicted that there will be moderate to heavy rain and local heavy rain in northern cities and counties of Shaoguan, Qingyuan, Pearl River Delta and western Guangdong today, and there will be (thunder) showers in other cities and counties. Thunderstorms are accompanied by short-term heavy precipitation and short-term strong winds of magnitude 8 or above. In the next few days, there will still be obvious precipitation in Guangdong.

　　[car home New Car Launches] On August 16th, the pagani Roadster was officially released at the Pebble Beach Auto Show, with the same power configuration as the hardtop version, with a global limited edition of 130 V12 engines and an overseas price of 3.4 million US dollars, about 24.654 million yuan.

　　Although the new car is a convertible version, the net weight of the car body is the same as that of the hardtop version, both of which are 1280 kg. The design of the convertible structure part is ingenious, and it can be completely disassembled with a skylight. Not surprisingly, the new car adopts carbon fiber single shell body, and continues the traditional design of butterfly door with upward folding, which is highly recognizable. The front engine room cover is smooth without too many curves. The headlight group continues to adopt the traditional double-willow shape, and the interior decoration part of the headlight also uses carbon fiber. In addition, the air inlet of the front face is designed to be large, which makes the new car have strong heat dissipation ability.

　　The rear half of the car body uses an integrated rear cabin cover, and there is an observation window at the engine, so you can enjoy the V12 engine from AMG at any time. In the rear part, the classic central four-outlet exhaust pipe divides the color matching spoiler into two parts, and the taillights on both sides are arranged vertically. The overall hollow shape of the rear part is obvious and very layered.

　　The interior continues the style and layout of the pagani supercar interior. There is no central control electronic screen, all physical buttons are decorated with a circle of blue lights, and almost all parts of the car are covered with leather or carbon fiber panels.

　　In terms of power, the new car is still equipped with a 6.0T twin-turbo V12 engine provided by AMG, with a maximum power of 864 HP and a peak torque of 1,100 Nm. The transmission system is matched with Xtrac 7-speed sequential gearbox, and manual transmission is also optional. In addition, the new car will be equipped with active suspension and innovative sensor system of Pirelli Cyber Tyre, which can monitor the status of Pirelli P Zero Corsa, Winter and Trofeo RS tires and transmit the real-time tire information back to the on-board computer, so as to regulate the traction control system, which can control the stability of the vehicle more accurately, thus exerting stronger performance potential under the premise of safety. (Text/car home Dai Wei)

"The new Braille books in the library are clearly printed, and the current Braille is used correctly, which is very suitable for blind people to read. There is also a special reading table for us blind people. How thoughtful! " On May 4th this year, in the reading room for the blind of Hefei Library, Mr. Jiang, a visually impaired person, said happily to You Yi, assistant procurator of the Third Procuratorate of Shushan District Procuratorate of Hefei.

Teacher Jiang experienced this change in Hefei Library, which benefited from the first administrative public interest litigation case of visually barrier-free information construction in our province handled by Shushan District Procuratorate. In January last year, the prosecutor of the hospital found that the daily reading needs of visually impaired people with disabilities were difficult to meet, Braille books were expensive and difficult to buy, and the borrowing process in some libraries was not smooth. After visiting local disabled persons’ federations, public welfare voluntary organizations and relevant administrative organs, and listening to the opinions of the visually impaired, the prosecutor further learned that the reading room for the blind in Hefei Library could not be used normally, and the configuration of barrier-free information exchange equipment such as Braille books, audio books, voice recording, large character reading equipment and software was not perfect, which made it inconvenient for the visually impaired to borrow. In view of the fact that the reading rights and interests of visually impaired people have not been effectively guaranteed, and the social public interests have been infringed, under the guidance of the provincial procuratorate and the designated jurisdiction of the Hefei Procuratorate, on April 12, 2022, the Shushan District Procuratorate filed an administrative public interest litigation investigation.

Since then, the hospital has held a round table meeting with relevant regulatory authorities to discuss the statutory duties of administrative organs, the implementation of the demands of disabled representatives, the rectification plan, and regulatory measures, and clarified the direction of rectification. On April 15th, the Procuratorate of Shushan District issued a pre-litigation procuratorial proposal to Hefei Culture and Tourism Bureau, stressing that promoting barrier-free environment construction is an important prerequisite for ensuring the disabled and other social members to fully and equally participate in social life. Information accessibility is an important part of barrier-free environment construction and an inevitable requirement for building an information society in an all-round way and promoting social fairness and justice. Hefei Library, as a subordinate unit of Hefei Culture and Tourism Bureau, has some shortcomings in the guarantee of barrier-free information construction. The bureau is responsible for the development of urban public culture and should perform its supervision and management duties according to law to avoid the infringement of social public interests. In view of this, according to the Public Library Law, Regulations on Barrier-free Environment Construction, Regulations on Protection of Disabled Persons in Anhui Province and Administrative Measures on Barrier-free Environment Construction in Anhui Province, this proposal requires Hefei Library to allocate Braille books and related reading equipment according to regulations, optimize the lending process, improve the construction of barrier-free information, and ensure that special groups can enjoy social public cultural services equally.

After receiving the procuratorial suggestions, Hefei Municipal Bureau of Culture and Tourism attached great importance to it and decided to launch a special campaign of "protecting the reading rights of visually impaired people" throughout the city, urging more than 30 libraries in Hefei and related communities to improve the construction of visually impaired reading facilities in time, speed up the transformation of information barrier-free environment, ensure the normal use of reading rooms for the blind, and at the same time, add existing Braille books for social sciences and literature. For this special rectification, Hefei Culture and Tourism Bureau gave a written reply to the Shushan District Procuratorate.

In order to consolidate the results of public interest litigation, on May 4th this year, the Procuratorate of Shushan District specially invited three representatives of visually impaired people and two volunteers of procuratorial cloud platform and supervisors of barrier-free environment construction to walk into Hefei Library for "looking back". Everyone browsed more than 200 new Braille books purchased by the library and experienced the "network+mail" borrowing process and new barrier-free information exchange equipment such as a book listening machine.

In Hefei Library, the Procuratorate of Shushan District, together with the public welfare organization for the protection of the disabled, also held a forum on the spot with the theme of "helping the disabled with culture and reading the light". During the discussion and exchange, participants in the "Looking Back" fully affirmed the efforts made by the procuratorial organs in helping to protect the reading rights and interests of disabled people, and put forward opinions and suggestions on the optimization of Braille book procurement categories, the compilation of e-books, the improvement of online lending process of Braille books, and the promotion of offline navigation volunteer service. The relevant person in charge of Hefei Library said that according to the suggestions and requirements put forward by everyone, the barrier-free information construction in the library will be continuously improved to ensure that special groups such as visually impaired people can better share the achievements of social and cultural services.

"Now the needs of dyslexic groups such as visually impaired people have new connotations and are more diverse. As a procuratorial organ, it should help this special group to share more colorful cultural products in an equal and timely manner with the power of the rule of law." You Yi said. She also told reporters that in the process of handling a series of public interest litigation cases in the fields of transportation and barrier-free information reading, the public interest litigation department of the hospital found that seven disabled representatives who participated in barrier-free environment experience had difficulties in life, and they were transferred to the court as clues for judicial assistance. Complaint and prosecution department. After investigation and verification, the procuratorate issued them a total of 34,000 yuan in judicial assistance.

On October 18th, this administrative public interest litigation case of visually barrier-free information construction handled by Shushan District Procuratorate was jointly rated as a typical case of public interest litigation of barrier-free environment construction by the Supreme People’s Procuratorate, Ministry of Housing and Urban-Rural Development and China Disabled Persons’ Federation. Chu Zhang

[Text/Caiquan Society & Daoge said that the car is shallow] When the price of domestic cars became more and more "outrageous", smart began to stretch. I still remember that the impression of smart at the beginning of the year was 200,000 exquisite cars. On April 14th, the rejuvenated smart Elves #1 and #3 actually jumped directly from 154,900 yuan and 164,900 yuan, which was really surprising. Among them, the guide price range of smart Genie #1 is 154,900-199,900 yuan, and the price is lowered by 25,000-26,000 yuan compared with the old model; The guide price range of smart Wizard #3 is 164,900-219,900 yuan, and the price is lowered by 36,000-55,000 yuan compared with the old model. The adjustment of price strategy reflects smart’s essential understanding of the current competition in the electric vehicle market in China.

While the product price is more close to the people, smart Elves #1 and #3 have repositioned the two products for the domestic market. According to the market environment and user research, some configurations are optimized in the new version, so as to better meet the actual consumption needs of users. At the same time, smart provides a variety of optional packages for close friends to match freely to meet the individual needs of users.

In order to help close friends have the Elf car as soon as possible, smart also launched multiple exclusive rights of close friends in a limited time, including limited-time optional preferential rights, flexible purchase and gift rights, free rights of special colors, replacement rights, repurchase rights, and delivery of bonus points. At the same time, there are various financial schemes such as "0 down payment" and "limited time and low interest" with the lowest annualized rate of 1.99%. The minimum daily supply is only a cup of milk tea, so that close friends can easily own a new luxury car. In addition, close friends can also enjoy four basic rights and interests, including super-long vehicle warranty, super-long three-power core parts warranty, worry-free one-button road rescue, unlimited traffic of vehicles and machines, which is thoughtful and sincere.

New luxury smart SUV, #1 riding the dust!

As the first global pure electric vehicle of smart brand, smart Elf #1 has been highly praised by the industry media and users for its new luxury aesthetics and excellent handling in different road conditions since its launch. Recently, this car has been delivered in batches in Hong Kong. The volume of orders in the past two months even exceeded the total sales of Porsche in Hong Kong in 2023. Among them, the performance version of BRABUS accounts for more than 90% of the orders, making it a veritable dark horse of the same class in the local sales. This achievement is undoubtedly remarkable for Hong Kong, a highly competitive market with picky consumers’ tastes.

Nowadays, this boutique car that has been riding in many consumer markets has ushered in a new look. In terms of face value, we continue to adopt the design philosophy of "Sensibility and Lingrui" tailored by Mercedes-Benz global design team: light and shadow penetrating front and rear LED headlights, frameless doors and hidden door handles, and "inspiration ring" suspended contrasting roof, which fully demonstrates the new luxury and fashion taste.

In the interior, it inherits the design concept of "compact outside and wide inside", with 20 flexible storage spaces and a minimalist T-shaped intelligent cockpit, creating a high-quality inspiration space for exclusive close friends.

Intelligently, it is equipped with the smart Pilot Assist intelligent driving system and the smart OS full-scene digital eco-car system, so that each elf has a lively and lovely elf assistant Avatar, and users can enjoy the intelligent and comfortable driving experience at any time.

New luxury sports coupe, open the door and see #3!

As the second global masterpiece of smart Elf series, smart Elf #3 has been released and delivered in many markets such as China and Europe, and has become the love of global hipster fans.

Externally, following the design philosophy of "sensibility and agility", smart Genie #3 won the blessing of the global design team of Mercedes-Benz: the avant-garde and dynamic slip-back shape, combined with the organic combination of muscular feeling and life lines, "stealing the mirror".

In terms of interior, the sports car-class low sitting posture, T-shaped smart cockpit with integrated embracing coupe seat and 1.6m2 immersive canopy further enhance the new luxury sports atmosphere owned by Smart Elf #3, which is "true atmosphere".

In addition, smart Genie #3 has the leading dynamic driving performance at the same level, and the dynamic four-wheel drive version is equipped with a dual-motor intelligent four-wheel drive system, which only takes 4.3s to accelerate 100 kilometers. The whole system adopts the former McPherson rear five-link independent suspension, and the sports chassis jointly adjusted by the smart team and the Mercedes-Benz expert team is "driving and controlling the true type".

It is worth mentioning that, at the launch conference of smart Genie #1 and #3, Tong Xiangbei, CEO of smart Brand Global Company, also implicitly poked a certain meter with high popularity recently. He sat in the car for example: this textured rubber made three bulges and hold the cup by the elasticity of the bulges. In this way, it lost eight moving parts compared with us. How much did it cost? Of course, this kind of texture looks like a brand from a distance, but in fact, if you look at this detail carefully, there is no way to see it everywhere.

The implication is that the control of smart cars in details is quite exquisite, which is not the same as that of some brands.

It can be seen that in order to occupy a place in this year’s more involved competition in China electric vehicle market, smart has not only prepared for the price, but also prepared for the product quality control. Smart Elves #1 and #3, which are already famous, will undoubtedly become a strong support for brand sales after price reduction and upgrading.

At the beginning of the year of "global transition", smart will continue to adhere to the core operation concept of "user center", bring new luxury travel and luxury quality to more close friends with a new look, and constantly "explore the best solution for future urban transportation".

Professor Yang Xichuan, Original Professor of Xichuan Xiaoliang Dermatology

| Editing/Typesetting: Fanny Editor: kiki&Jeing Audit: Li Yun

Fact is stranger than fiction. There are thousands of diseases in the world, which are particularly strange and rare?

Today, Xiao Liang, a boy♂ who is keen on studying the mysteries of the body, will take you close to science and learn about four bizarre and rare human diseases that may be unknown to 90% people (strange knowledge has increased again).

Please note that there is continuous high energy ahead, and timid students should be careful ~

NO.1 Shuren disease: hands and feet are covered with "branches and roots"

I’m sure you’ve all heard about vegetative state, but have you ever heard of Shuren? What do you think of first? The cute Groot in Marvel Comics’s movies?

(Source: dribbble/Hancooock)

The tree people in the movie can love each other, but in real life, the "tree people" have to suffer from "tree people’s disease".

Shuren’s disease, medically known as "epidermodysplasia verrucosa", is a rare hereditary skin disease caused by human papillomavirus (HPV) infection, which may be related to gene mutation. It usually begins between the ages of 4 and 8, and most often begins before the age of 20.

People with Shuren’s disease usually grow many sarcomas, maculae and papules that look like branches and roots on their hands and feet, which not only affect the appearance, but also make it inconvenient for daily life, and also turn into skin cancer with high winds.

(Indonesian man suffering from Shuren disease)

Unfortunately, there is no unified and effective solution to this disease at present. Some studies think that retinoids can improve it to some extent. In addition, patients should avoid excessive sun exposure, and if they are prone to cancer, they should be operated immediately or removed by other methods.

NO.2 Premature senility: 7-year-old age and 70-year-old appearance

Anti-aging is the pursuit of many people. Who doesn’t want to be younger and more energetic every year? However, in this world, some people actually get old and even die early at a young age because of a rare genetic disease-premature senility.

Art comes from life. It is said that the film "The Curious Case of Benjamin Button" (also known as "Rejuvenation") may be inspired by premature senility, but the time sequence is reversed. The hero of the film looks like an old man of 70 or 80 at birth. As time goes by, the people around him are getting older, but he is rejuvenating, getting younger and younger, and finally returning to the baby form and dying in the arms of an old lover.

(Source: Movie "The Curious Case of Benjamin Button")

If the protagonist’s life is a bizarre movie, then in reality, patients with premature senility live a life like pressing the acceleration button, aging faster than their peers, feeling the rapid failure of every body organ every day, and dying before they bloom.

There are some heartbreaking facts about premature senility:

● Premature senility in adults: Patients usually develop normally before puberty. At the age of 20-30, they begin to have aging characteristics such as skin wrinkles, muscle atrophy, gray hair and shedding, and the average age of death is 47 years old.

● Premature senility in children: The patient is normal at birth, but after birth, the appearance and body organs will accelerate the aging and decline, and with the increase of age, he will suffer from various diseases such as cardiovascular disease, and the average age of death is only 13 years old.

(patients with premature senility)

NO.3 Vampire: You can only live in darkness.

Legend has it that there are zombies in the East and vampires in the West. Speaking of vampires, you may think of the handsome "ghosts" of noble Leng Yan in film and television dramas. In real life, many people are willing to believe that vampires exist in some corner of the world, but in the medical field, "vampires" really may exist, and they are porphyria patients.

You can slide left and right to view the picture, but it is recommended to slide carefully!

Porphyrin (bD lí n) disease is a rare metabolic disease caused by the lack of enzyme activity in heme biosynthesis pathway, which leads to abnormal increase of porphyrin or its precursor concentration and accumulation in tissues, resulting in cell damage. In 2020, experts in the diagnosis and treatment of porphyria agreed to divide porphyria into the following categories:

(Source: Literature [4])

When the medical profession knew nothing about porphyria hundreds of years ago, patients with porphyria were often considered as legendary vampires, which may be because some symptoms of porphyria are very similar to the image of vampires.

photophobia

People suffering from porphyria will be as afraid to be exposed to the sun as vampires, because they will get sick when they see light, and their skin will have photosensitive reaction, blisters, scars, deformities, etc., and in severe cases, they may be accompanied by the loss of fingers, eyelids, nose and ears.

"bloodthirsty"

Unlike vampires who directly suck people’s necks to drink blood, porphyria patients are "bloodthirsty" by blood transfusion to achieve treatment and relief.

Look different from ordinary people

The high level of porphyrin in red blood cells of patients with porphyria can lead to hemolysis, and severe hemolysis often leads to anemia, so it may cause pallor.

However, people with congenital erythropoietic porphyria will show red or brown color in their teeth, bones and urine due to excessive porphyrin, and they will fluoresce when exposed to ultraviolet rays, which really looks a bit like vampires who have just eaten their children.

NO.4 werewolf syndrome: a real hairy child

Everyone has Mao Mao, but people with werewolf syndrome have a lot of Mao Mao.

However, this werewolf is not a werewolf. The so-called werewolf syndrome actually refers to "congenital systemic hirsutism". The patient’s whole body is covered with thick hair, which is beyond the normal physiological range of the same age, gender and race, and seems to be the image of a werewolf in our impression. In addition to excessive hair, it is usually accompanied by facial deformities.

(Source: Literature [6])

The prevalence rate of werewolf syndrome is extremely low, and it was once considered as an "atavism" phenomenon. However, at present, most studies believe that patients suffer from this disease because of unknown genetic defects.

Patients with the above diseases are often noticed by people in their daily lives because of their abnormal appearance, but who doesn’t want to be healthy and safe in life, and who would like to do so if they could start over.

When you meet them in your life, please be less discriminating and misunderstanding, and more understanding and kindness. I also hope that medical technology will be more developed in the future, so that these special patients can get better treatment and return to ordinary people’s lives.

[References]

[1]Agharbi FZ. Epidermodysplasie verruciforme: à propos d’un cas [Epidermodysplasia verruciformis: about a case]. Pan Afr Med J. 2018 May 29; 30:78. French. doi: 10.11604/pamj.2018.30.78.16058. PMID: 30344862; PMCID: PMC6191268.

Yang Hui, Liu Wan, Chang Jianmin. Verrucous epidermal dysplasia [J]. Journal of Clinical Dermatology, 2015:13-14.

Wang Zehua, Li Hongyu, Qu Jing, Zhang Weiqi, Liu Guanghui. Pathogenesis and intervention methods of human premature senility [J]. Progress in biochemistry and biophysics, 2018,45(09):926-934.

[4] Erythrocyte Disease (Anemia) Group, Hematology Branch, Chinese Medical Association. Expert Consensus on Diagnosis and Treatment of Porphyrin Disease in China (2020) [J]. Chinese Medical Journal, 2020,100 (14): 1051-1056.

[5]Pavone P, Praticò AD, Falsaperla R, Ruggieri M, Zollino M, Corsello G, Neri G. Congenital generalized hypertrichosis: the skin as a clue to complex malformation syndromes. Ital J Pediatr. 2015 Aug 5; 41:55. doi: 10.1186/s13052-015-0161-3. PMID: 26242548; PMCID: PMC4526284.

[6]Sun M, Li N, Dong W, Chen Z, Liu Q, Xu Y, He G, Shi Y, Li X, Hao J, Luo Y, Shang D, Lv D, Ma F, Zhang D, Hua R, Lu C, Wen Y, Cao L, Irvine AD, McLean WH, Dong Q, Wang MR, Yu J, He L, Lo WH, Zhang X. Copy-number mutations on chromosome 17q24.2-q24.3 in congenital generalized hypertrichosis terminalis with or without gingival hyperplasia. Am J Hum Genet. 2009 Jun; 84(6):807-13. doi: 10.1016/j.ajhg.2009.04.018. Epub 2009 May 21. PMID: 19463983; PMCID: PMC2694973.

[disclaimer]

The data in this article was updated on May 14th, 2021.

It was originally written by Professor Yang Xichuan, a dermatologist, aiming at popularizing science for readers.

Popular science content can not replace doctors’ diagnosis and treatment opinions, and is for reference only.

If you have skin problems, please consult a doctor in time.

Some pictures are from the Internet. If there is any infringement, please contact to delete them.

Cover image source: blurrr

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Five blind people with special skills are playing cards. Jiang Yuejun

　　Others don’t let their opponents see the cards when they play cards, but they don’t: some of the cards in their hands are facing up and some are facing down, and they always tilt their heads and lean sideways when playing cards, and their hands are constantly pinching the cards, while they are "listening" with rapt attention … This is the scene that the reporter saw five blind people playing cards in Fangjia, Yang Qiu, a villager in Hanyangwang Village, Danyang City yesterday. Yang Qiufang, a blind man, told reporters that they all play cards by "touching" with their hands, "listening" with their ears and "remembering" with their hearts, but the most important thing is to trust each other and never cheat. It is because of this honesty that five blind people get great happiness from it.

　　Special skills are more magical than magic.

　　"Blind people can’t see, how can they play cards?" With curiosity, the reporter came to the home of Yang Qiufang, a blind man in Hanyangwang Village, Houxiang Town, Danyang yesterday morning. As soon as he entered the door, he saw five blind people sitting around playing "four hits one (a local poker game)".

　　The reporter saw at the scene that in order to ensure the speed, a villager was responsible for licensing them, and five blind people were in no hurry, touching them one by one and holding them in their hands. The reporter found that when they got the card, the thumbs of the five blind people touched the top of the card, and then they were sandwiched between five fingers according to the number and color, and the card was smooth, and the speed was not much slower than that of the healthy people.

　　"Three’ 4′ band pairs’ 6′!" A blind man in his 50 s sitting by the door played cards, and another blind man sitting below immediately drew five cards and said, "Three’ K’ s are paired with’ 3’"; "Bomb, four’ 7′!" The blind man by the door brushed the ground and threw out four cards … Although the five blind people couldn’t see the cards thrown out by the other side, they were very quick-witted, and played with relish with the particularly loud shouting. It’s hard to imagine that they couldn’t see at all if they weren’t at the scene.

　　The reporter was puzzled. After obtaining the consent of 76-year-old Ge Yunliang, the reporter took the cards in his hand. The scene in front of him shocked the reporter. The cards were arranged in order of size, and the cards of the same color were neatly put together, which was not chaotic at all. Its magic is comparable to Liu Qian’s magic.

　　A new deck of cards can be mastered in three days.

　　The reporter also touched it with his fingers, feeling that the numbers and colors on the card were not concave and convex at all, not Braille cards, and he couldn’t feel it when he touched it. Closing his eyes was more like touching a piece of paper. How do these five completely blind people "recognize cards"? On what basis can you make a judgment quickly?

　　The reporter asked what the trick was, and they said, tell you, you can’t touch it. Don’t say that you are a normal person, even other blind people can’t touch it. The reporter observed at the scene that with the "deepening" of the game, these blind people gradually got excited, and the speed of playing cards was obviously faster, and occasionally they made mistakes. For example, if you shout "a pair of twos", the cards issued are a two and a three, and the dealer and spectators will remind them in time.

　　In order to verify the skills of five blind people to touch and read cards again, the reporter specially bought a deck of ordinary poker in the supermarket and took it out for them to change cards. Unexpectedly, several people went on as usual, and it was basically accurate. Yang Qiufang also told reporters that this pair of poker bought by reporters is the third-generation "Three Guns" brand, which is more difficult to touch than the first and second generations, because compared with the first and second generations, paper and printing are different, although ordinary people can’t feel it, but in fact there are still very subtle differences in their hands. The numbers and colors on the first and second generations are still slightly concave and convex, while the three generations feel smoother. But as long as you give him three days, they will soon be proficient.

　　reveal a secret

　　Why did you practice this trick?

　　Ink handwriting can be felt.

　　Yang Qiufang, a blind man, told reporters that there are many blind friends around him, but only five of them can play cards, because several of them often study and ponder together, and other blind people don’t have the patience. Of course, this also requires some talent. He told reporters that the youngest of them is only 46 years old. He was sick and blind when he was in high school. He is very smart and can find out the colors in a short time. He said that if normal people calm down and ponder hard, they should also feel this way. Although the concave and convex of the card is very subtle, there are ink marks after all. He told reporters that they can not only touch the cards, but also know the counterfeit money that the money detector can’t identify, and they can also touch the pen words written on the paper. It is said that practice makes perfect.

　　"I can feel what cards are in my hand, but what if others deliberately make mistakes?" When the reporter made this remark, Yang Qiu and his blind friends all laughed and repeatedly said, "We don’t play cards blindly. Although we can’t see it, we have to rely on our consciousness and trust to play cards. Otherwise, how can we fight? Besides, what happiness can we have if we cheat each other? We play cards by heart and play with heart. "

　　The reporter learned in the interview that these five blind people knew each other in their early years, and they have been playing cards together for more than ten years, and occasionally they will get a little reward. In the process of learning card art, "card friends" not only forged a deep friendship, but also enriched their lives. It’s amazing that five people who live completely in the dark can cross the visual barrier and enjoy playing poker together.

Editor: Peng Wei

Dr. Guan Kang Kang You from the Department of Nuclear Medicine talks about thyroid gland.

1. What is pepsinogen?

Pepsinogen (PG) is the precursor of pepsin. According to its biochemical properties and immunogenicity, it can be divided into two subgroups. The immunogenicity of 1~5 components is the same, and it is called Pepsinogen I (PG I), which is mainly secreted by the main cells of gastric fundus gland and mucus neck cells. Components 6 and 7 are called pepsinogen Ⅱ(PGⅡ), which can be secreted by the main cells and mucus neck cells of gastric fundus gland, and also produced by mucus neck cells of pyloric gland of cardiac gland and gastric antrum and upper duodenum.

Usually, about 1% PG enters the blood circulation through the capillary of gastric mucosa, and the PG entering the blood circulation is very stable in the blood. Serum PG ⅰ and PG ⅱ reflect the number of glands and cells in gastric mucosa, and indirectly reflect the secretory function of different parts of gastric mucosa. When pathological changes occur in gastric mucosa, the content of serum PG also changes. Therefore, monitoring the concentration of PG in serum can be used as a means to monitor the status of gastric mucosa.

Detection of pepsinogen (PG), an early warning indicator of gastric cancer

1. Chronic atrophic gastritis is an important "transitional event" in gastric mucosa canceration.

Gastric cancer is one of the common malignant tumors in China, and its mortality ranks first among all kinds of malignant tumors. Its early diagnosis and early treatment have become the only way to improve the quality of life of patients and reduce the mortality. At present, the main methods for diagnosing gastric cancer are fiberoptic gastroscopy and upper gastrointestinal radiography, among which gastroscopy is called the "gold standard" for diagnosing gastric cancer.

At present, it is believed that partial atrophy can be reversed, and once it enters intestinal metaplasia, it is difficult to reverse it. Therefore, there is an urgent need for a tool that can keenly detect the atrophy of gastric mucosa. At this time, the detection of pepsinogen plays a powerful role.

When the gastric fundus gland atrophied, the number of main cells decreased and the level of PG ⅰ decreased. However, because there are more cells secreting PG ⅱ, PG ⅱ can still maintain a high level at this time, and the ratio of PG ⅰ to PG ⅱ decreased significantly. When atrophic gastritis is accompanied by intestinal metaplasia and gastric antrum gland extends to the stomach body, and pseudopyloric metaplasia of gastric fundus gland occurs, the level of PG ⅱ increases more, and the ratio of PG ⅰ to PG ⅱ decreases further. Therefore, the decrease of PG ⅰ level is a reliable sign of gastric fundus gland mucosa atrophy, and PG ⅰ/PG ⅱ profile reflects the degree of gastric fundus gland mucosa atrophy.

2. Helicobacter pylori infection is the initiating factor for the development of gastric cancer.

The occurrence of gastric cancer is the result of multiple factors. The multi-step hypothesis of gastric cancer, that is, from chronic non-atrophic gastritis (formerly known as chronic superficial gastritis) → atrophic gastritis → intestinal metaplasia → intraepithelial neoplasia (formerly known as dysplasia) → gastric cancer, has been generally accepted. Helicobacter pylori (Hp) infection has become the most important initiating factor, and Hp infection has been recognized as an independent risk factor for gastric cancer.

Therefore, active detection of Hp has become one of the important measures to prevent and treat gastric cancer. Hp detection is mainly divided into invasive and non-invasive methods. For Hp-positive infected people, the major guidelines have reached a consensus that Hp infection-related gastritis is an infectious disease and it is recommended to eradicate it.

Hp infection can also significantly affect the serum PG level. At the beginning, PG ⅰ and PG ⅱ both increased, and the increase of PG ⅱ was faster, then PG ⅰ/PG ⅱ decreased, and the larger the Hp infection focus, the greater the decrease of PG ⅰ/PG ⅱ. However, the results of pepsinogen test are lack of specificity, and special Hp test is still needed to judge whether Hp is infected or not.

Third, pepsinogen Ⅰ(PGⅠ),

The results of pepsinogen Ⅱ(PGⅡ) were analyzed as follows:

Four, "pepsinogen" test results misunderstanding:

Myth # 1: If only PG ⅰ is measured during physical examination, nearly 70% of the results are in the range of 40~70ng/mL, which seems to be lower than 70ng/mL on the surface, and gastric atrophy is suspected, but the results are difficult to explain because PG ⅱ and ratio are not measured. When PGⅡ is retested, the ratio of more than 90% is greater than 3. This kind of situation is due to the high incidence of chronic superficial gastritis in China population, which belongs to normal physiological gastric acid secretion insufficiency.

Myth 2: PG-positive means "stomach cancer theory": positive means people at high risk of stomach cancer. PG project is a simple screening project for gastric cancer in the early stage of physical examination, replacing X-ray and ultrasonic screening for gastric cancer. The main significance lies not in diagnosis but in early detection and prevention. Normal people are 15%PG positive, and those with PG positive have a high risk of developing gastric cancer, and the early detection rate of gastric cancer is 1%~2%.

Myth # 3: Pay attention to the change of reference range values of PG ⅰ and PG ⅱ, but not the ratio. Because the secretion of PG ⅰ in gastric mucosa changes greatly (above 70~800ng/mL) under the attack of inflammation, the secretion of PG ⅱ is relatively constant. When comparative value > 3, the degree of PG ⅰ increase can only be combined with clinical analysis to determine the type of gastric diseases. When comparative value < 3, it is suggested that further in-depth endoscopy or pathological sampling should be taken to confirm and warn the high risk of early gastric cancer, and follow-up monitoring should be carried out in the last five years. The incidence of gastric cancer was 2% in PG-positive patients who had no gastric cancer in the same year and in the following five years.

Five, Japan’s experience for reference ("ABC" method+endoscopic screening)

Our neighbor Japan, as a country with high incidence of gastric cancer, has done a very good job in early cancer screening. Their screening strategy for early cancer firmly grasps the two controllable factors of Hp infection and whether gastric fundus gland atrophy occurs.

The Kyoto Consensus of Japan made the following recommendations for the national early cancer screening strategy: first, for Hp infection, the Kyoto Consensus emphasized "shoot to kill", and after everyone sterilized and eradicated Hp, PG was evaluated. The ratio of PG ⅰ/PG ⅱ is ≤3.0, which is regarded as the critical diagnostic value of atrophic gastritis, and as the screening standard of high-risk population of gastric cancer.

Vi. A Long Way to Go-Strategies for Early Cancer Screening in China;

China has a large population base and the incidence of gastric cancer remains high, so it is imperative to find a simple, accurate and effective screening method for gastric cancer. In 2017, the China Consensus on Chronic Gastritis highly affirmed the value of PG, and the guidelines gave the following recommendations: The detection of serum pepsinogen (PG) ⅰ and ⅱ and gastrin -17 may help to judge whether there is gastric mucosal atrophy and its degree. Detection of serum PG ⅰ, PG ⅱ, PG ⅰ/PG ⅱ ratio combined with anti-Hp antibody is helpful for risk stratification management.

The Expert Consensus on Early Gastric Cancer Screening Process in China, published at the end of 2017, not only affirmed the value of serum PG, but also put forward a new gastric cancer screening scoring system, in which the elderly, male, Hp antibody positive, low pepsinogen ratio (PGR) and high serum 17(gastrin-17 (G-17) level are high risk factors for gastric cancer.

Among them, G-17 is a new item in China Guide. G-17 is an amidated gastrin synthesized and secreted by G cells in gastric antrum. Its main physiological function is to stimulate gastric acid secretion and promote the proliferation and differentiation of gastric mucosal cells. G-17 is one of the sensitive indexes to reflect the endocrine function of gastric antrum, which can indicate the atrophy of gastric antrum mucosa or whether there is abnormal proliferation. G-17 itself can also promote the occurrence and development of gastric cancer. When the serum G-17 level rises, it may indicate the risk of gastric cancer.

In addition, different from the Kyoto consensus, the consensus in China put forward the critical value of serological detection for the first time, that is, when PGR<3.89 and G-17> 1.50pmol/L, the risk of gastric cancer increased significantly. The critical value of PGR defined by Kyoto Consensus is ≤3.

According to the score, the guide divides the population into three groups: low risk, medium risk and high risk, and gives the screening strategy.

At the same time, however, we should also see the shortcomings of the China guidelines. The screening population is over 40 years old, and there are other risk factors such as high incidence area of gastric cancer, Hp infection, previous precancerous diseases of gastric cancer, first-degree relatives of gastric cancer patients, diet and so on. However, at present, the onset age of gastric cancer is getting earlier and earlier, and I believe it will definitely enter prospecting stage in the future.

To sum up, serum PG combined with Hp detection is helpful to evaluate the risk of gastric cancer, and can be used as a routine screening method for gastric cancer for ordinary people. However, it cannot replace gastroscopy, and gastroscopy is still strongly recommended for high-risk groups.

Original title: Clinical Significance of Detection of Pepsinogen (PG)

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