As the saying goes, "a thousand dollars can’t buy old people to lose weight." Nowadays, many old people have joined the army to lose weight, and it seems that they will be healthy if they lose weight. Recently, a study published in the American Obesity magazine shows that the elderly’s deliberate weight loss may affect their bone health.

　　Body mass index BMI= the square of weight/height, which is an accepted standard to measure obesity. In this study, 77 students with an average BMI of 33.6 (usually 18.5≤ BMI index ≤ 23.9 old people with normal weight, more than 29.9 are severely obese) were given weight-loss intervention for 18 months, and the overall weight of the old people and the bone mineral density of the areas (total hip, femoral neck, lumbar vertebrae and trabecular bone) were monitored and scored at 18 months and 30 months. The results show that the decline of hip bone mineral density will last for one year after weight-loss intervention for elderly obese patients, whether they rebound or not. The study also found that fat loss and weight loss reduced the bone mineral density of hip and increased the risk of osteoporosis.

　　Gou Bo, a professor in the Department of Health Sciences of Xi ‘an Institute of Physical Education, said that if the elderly lose weight improperly, such as excessive diet control, resulting in insufficient nutrition intake, or lose weight too much and too fast, resulting in significant weight loss, it will lead to a decline in bone density. Older people do not have to lose weight if they are only slightly obese and have no obvious cardiovascular disease. If there are some contraindications to exercise, and it is not suitable for exercise to lose weight, you can seek nutrition, medical care and other methods to control your weight under the guidance of a doctor. If obesity is accompanied by other chronic diseases, lose some weight appropriately. In principle, adopt safe and effective methods to achieve the goal at a slower speed such as diet control and exercise.

　　Many old people find that even if they eat and exercise as much as when they were young, it is easy to "gain weight". The reason is that the basal metabolic rate and muscle mass of adults decrease year by year with age. Therefore, even if the elderly eat less, their digestion and absorption ability are poor, and the balance of energy in and out is still "less in and out", in which case it will be "fat".

　　Gou Bo emphasized that obesity will directly affect heart function and vascular health, and it is easy to suffer from various cardiovascular and cerebrovascular diseases. The ideal situation is to "gain muscle and lose fat" on the premise of ensuring basic nutrition.

　　Old people can’t take extreme measures to lose weight, let alone go on a diet like young people. We can start with the moderation and choice of dinner, eat some coarse grains instead of staple food, eat food with high protein content for breakfast, and control the staple food at about 2 Liang at noon. It is not recommended to choose diet pills or surgery to lose weight.

　　In sports, it is suggested that aerobic exercise should be combined with strength training, and it is best to take some soothing forms, such as Tai Ji Chuan, yoga, walking, etc. As long as you can persist every day and achieve a certain amount of exercise, you can lose weight completely.

　　Interviewed expert: Professor Gou Bo, Department of Health Sciences, Xi ‘an Institute of Physical Education

According to CCTV news, the reporter learned from the press conference on the prevention and control of COVID-19 epidemic in Baise City, Guangxi Province held in Debao County on the afternoon of the 14th that some people found that they had never been to medium and high-risk areas, but the health code turned into a yellow code or a red code. If this happens, it can be transcoded in the following ways:

First, through the abnormal feedback function of Guangxi Health Code-Scan Code Anti-epidemic applet, we can make independent complaints about personal health code abnormality, upload screenshots of travel cards, screenshots of nucleic acid detection reports, health commitment letters and other supporting materials, and the administrators of counties, townships or towns, streets and districts will complete the processing within 24 hours after receiving the information reminder of the health code abnormality feedback processing list within their jurisdiction.

The second is to report to the unit, the property of the residential area and the local community and village by telephone. By the county or township, street zoning administrator to meet the conditions of restoring the green code personnel transcoding.

Third, other situations can be consulted and reflected through the 12345 hotline.

Editor Zhao Xi

At one o’clock this morning, the annual "Spring Festival Evening" in the science and technology circle-Apple Autumn New Product Launch Conference was held in Apple Park Park. The good news is that this time Apple launched three new iPhone：iPhone XS, iPhone XS Max and iPhone XR. The bad news is that the prices are not "close to the people", especially the largest iPhone Xs Max, with a maximum price of 12,799 yuan. Earlier, some netizens laughed and said, "If you can’t afford it, you will stay up late to watch the live broadcast. Local tyrants will wake up and buy it directly!" This article will take those friends who are neither local tyrants nor watching the live broadcast to relive the dry goods of the conference.

Focus!

1. Apple released three new iPhones, the model of which is iPhone XS/XS Max/XR, and an Apple Watch Series 4； that supports ECG function;

2, the strongest mobile phone chip in history, three new iPhone products all adopt Apple’s latest bionic chip A12；;

3. The China version of iPhone XS Max and iPhone XR have added support for dual card dual standby, which is the first time in the history of Apple mobile phones;

4, the price hit a new high, the highest price of iPhone XS Max licensed is 12,799 yuan.

5, Apple Watch Series 4 is equipped with a new S4 chip, which supports ECG ECG function.

It is worth mentioning that after three new iphones were put on the shelves of Apple official website, last year’s iPhone was officially discontinued in Apple official website. However, the previous flagship models-iPhone 8 and iPhone7-are still available for sale. The official explanation given by Apple is that users can buy iPhones through authorized dealer channels. Although the price of iPhone has been reduced by nearly 2,000 yuan, it is still higher than that of iPhoneXR just released. Presumably, people who plan to buy iPhone may be more willing to save a few hundred yuan to buy a new iPhone equipped with Apple A12 processor.

Now, let’s see what else.futuristic techBirth ▼

Double card and double standby, underwater bubble for 30 minutes without pressure.

After 10 years, the iPhone finally supports dual cards! IPhone XS Max supports dual card dual standby.

Apple made a dual-card version specially for China. IPhone XS Max can insert two cards directly, using the design of inserting cards on the front and back of a single card slot similar to OPPO Find X. (Dual telecom cards are not supported)

In addition, waterproof has reached the level of IP68, which means that the mobile phone can be placed under water for up to 30 minutes. If you accidentally drop it in the swimming pool, it doesn’t matter. Pick it up, blow it again, and it will be fine when it is dry.

"The first 7 nm A12 bionic biochip in the industry"

All three new iPhone products use Apple’s latest bionic chip A12.

Last year, the operation of A11 bionic chip could reach 60 million operations per second, so in A12 bionic chip, the operation data per second reached 5 trillion.

This power is mainly reflected in the following points:

The first is display performance.For example, portrait mode, portrait lighting effect, animated expressions, AR experience, Siri shortcuts, etc. all have great demand for neural network engines.

Followed by the AI camera.IPhone XS and iPhone XS Max have wide-angle and telephoto rear cameras, both of which are 12-megapixel sensors. A12 chip can automatically perform exposure or white balance, and can also reduce dryness.

In the portrait mode of the camera, the depth of field function is also added, so that users can automatically isolate the subject and blur the background, and the effect is very good.

Apple Watch Series 4

Apple also launched the Apple Watch Series 4 smart watch today, which is the first major design transformation of Apple Watch in more than three years-the most intuitive improvement is a larger display with radians and almost no borders at the edges.　

The dial can display more information (BBC).

The biggest highlight is its health functions, including:Measure heartbeat and abnormal prompt、Fall detectionandSOS emergency contactandElectrocardiogram generating function . Users can also put their fingers on it at any time to see the real-time ECG and heart rate, and the whole process takes only 30 seconds.　

Version and price

There are two versions of Apple Watch Series 4, the separate GPS version starts at 3199 yuan, and the GPS+cellular network version starts at 3999 yuan.

Sale time

Ordering began on September 14th, and it will be released on September 21st.

The fruit powder cried and Huawei smiled …

As soon as the price of the new iPhone was announced, fruit powder said "can’t afford it".

However, there is another episode: at about 3 o’clock, Yu Chengdong, senior vice president of Huawei Technologies Co., Ltd., wrote in his personal Weibo:Steady, I’ll see you in London on October 16th!Subsequently, Huawei PK Apple’s brand spoof map appeared on the Internet.

It seems that after reading the conference, Huawei is very confident. As for the people who eat melons, it is still the price issue that is more spit.

Do you want to buy the new iPhone? Have you paid off last year’s installment?

Source: Qilu Net Comprehensive People’s Network, WeChat public number: ZEALER, Popular Science China, 21st century business herald, Sina Weibo.

Professor Yang Xichuan, Original Professor of Xichuan Xiaoliang Dermatology

| Editing/Typesetting: Fanny Editor: kiki&Jeing Audit: Li Yun

Fact is stranger than fiction. There are thousands of diseases in the world, which are particularly strange and rare?

Today, Xiao Liang, a boy♂ who is keen on studying the mysteries of the body, will take you close to science and learn about four bizarre and rare human diseases that may be unknown to 90% people (strange knowledge has increased again).

Please note that there is continuous high energy ahead, and timid students should be careful ~

NO.1 Shuren disease: hands and feet are covered with "branches and roots"

I’m sure you’ve all heard about vegetative state, but have you ever heard of Shuren? What do you think of first? The cute Groot in Marvel Comics’s movies?

(Source: dribbble/Hancooock)

The tree people in the movie can love each other, but in real life, the "tree people" have to suffer from "tree people’s disease".

Shuren’s disease, medically known as "epidermodysplasia verrucosa", is a rare hereditary skin disease caused by human papillomavirus (HPV) infection, which may be related to gene mutation. It usually begins between the ages of 4 and 8, and most often begins before the age of 20.

People with Shuren’s disease usually grow many sarcomas, maculae and papules that look like branches and roots on their hands and feet, which not only affect the appearance, but also make it inconvenient for daily life, and also turn into skin cancer with high winds.

(Indonesian man suffering from Shuren disease)

Unfortunately, there is no unified and effective solution to this disease at present. Some studies think that retinoids can improve it to some extent. In addition, patients should avoid excessive sun exposure, and if they are prone to cancer, they should be operated immediately or removed by other methods.

NO.2 Premature senility: 7-year-old age and 70-year-old appearance

Anti-aging is the pursuit of many people. Who doesn’t want to be younger and more energetic every year? However, in this world, some people actually get old and even die early at a young age because of a rare genetic disease-premature senility.

Art comes from life. It is said that the film "The Curious Case of Benjamin Button" (also known as "Rejuvenation") may be inspired by premature senility, but the time sequence is reversed. The hero of the film looks like an old man of 70 or 80 at birth. As time goes by, the people around him are getting older, but he is rejuvenating, getting younger and younger, and finally returning to the baby form and dying in the arms of an old lover.

(Source: Movie "The Curious Case of Benjamin Button")

If the protagonist’s life is a bizarre movie, then in reality, patients with premature senility live a life like pressing the acceleration button, aging faster than their peers, feeling the rapid failure of every body organ every day, and dying before they bloom.

There are some heartbreaking facts about premature senility:

● Premature senility in adults: Patients usually develop normally before puberty. At the age of 20-30, they begin to have aging characteristics such as skin wrinkles, muscle atrophy, gray hair and shedding, and the average age of death is 47 years old.

● Premature senility in children: The patient is normal at birth, but after birth, the appearance and body organs will accelerate the aging and decline, and with the increase of age, he will suffer from various diseases such as cardiovascular disease, and the average age of death is only 13 years old.

(patients with premature senility)

NO.3 Vampire: You can only live in darkness.

Legend has it that there are zombies in the East and vampires in the West. Speaking of vampires, you may think of the handsome "ghosts" of noble Leng Yan in film and television dramas. In real life, many people are willing to believe that vampires exist in some corner of the world, but in the medical field, "vampires" really may exist, and they are porphyria patients.

You can slide left and right to view the picture, but it is recommended to slide carefully!

Porphyrin (bD lí n) disease is a rare metabolic disease caused by the lack of enzyme activity in heme biosynthesis pathway, which leads to abnormal increase of porphyrin or its precursor concentration and accumulation in tissues, resulting in cell damage. In 2020, experts in the diagnosis and treatment of porphyria agreed to divide porphyria into the following categories:

(Source: Literature [4])

When the medical profession knew nothing about porphyria hundreds of years ago, patients with porphyria were often considered as legendary vampires, which may be because some symptoms of porphyria are very similar to the image of vampires.

photophobia

People suffering from porphyria will be as afraid to be exposed to the sun as vampires, because they will get sick when they see light, and their skin will have photosensitive reaction, blisters, scars, deformities, etc., and in severe cases, they may be accompanied by the loss of fingers, eyelids, nose and ears.

"bloodthirsty"

Unlike vampires who directly suck people’s necks to drink blood, porphyria patients are "bloodthirsty" by blood transfusion to achieve treatment and relief.

Look different from ordinary people

The high level of porphyrin in red blood cells of patients with porphyria can lead to hemolysis, and severe hemolysis often leads to anemia, so it may cause pallor.

However, people with congenital erythropoietic porphyria will show red or brown color in their teeth, bones and urine due to excessive porphyrin, and they will fluoresce when exposed to ultraviolet rays, which really looks a bit like vampires who have just eaten their children.

NO.4 werewolf syndrome: a real hairy child

Everyone has Mao Mao, but people with werewolf syndrome have a lot of Mao Mao.

However, this werewolf is not a werewolf. The so-called werewolf syndrome actually refers to "congenital systemic hirsutism". The patient’s whole body is covered with thick hair, which is beyond the normal physiological range of the same age, gender and race, and seems to be the image of a werewolf in our impression. In addition to excessive hair, it is usually accompanied by facial deformities.

(Source: Literature [6])

The prevalence rate of werewolf syndrome is extremely low, and it was once considered as an "atavism" phenomenon. However, at present, most studies believe that patients suffer from this disease because of unknown genetic defects.

Patients with the above diseases are often noticed by people in their daily lives because of their abnormal appearance, but who doesn’t want to be healthy and safe in life, and who would like to do so if they could start over.

When you meet them in your life, please be less discriminating and misunderstanding, and more understanding and kindness. I also hope that medical technology will be more developed in the future, so that these special patients can get better treatment and return to ordinary people’s lives.

[References]

[1]Agharbi FZ. Epidermodysplasie verruciforme: à propos d’un cas [Epidermodysplasia verruciformis: about a case]. Pan Afr Med J. 2018 May 29; 30:78. French. doi: 10.11604/pamj.2018.30.78.16058. PMID: 30344862; PMCID: PMC6191268.

Yang Hui, Liu Wan, Chang Jianmin. Verrucous epidermal dysplasia [J]. Journal of Clinical Dermatology, 2015:13-14.

Wang Zehua, Li Hongyu, Qu Jing, Zhang Weiqi, Liu Guanghui. Pathogenesis and intervention methods of human premature senility [J]. Progress in biochemistry and biophysics, 2018,45(09):926-934.

[4] Erythrocyte Disease (Anemia) Group, Hematology Branch, Chinese Medical Association. Expert Consensus on Diagnosis and Treatment of Porphyrin Disease in China (2020) [J]. Chinese Medical Journal, 2020,100 (14): 1051-1056.

[5]Pavone P, Praticò AD, Falsaperla R, Ruggieri M, Zollino M, Corsello G, Neri G. Congenital generalized hypertrichosis: the skin as a clue to complex malformation syndromes. Ital J Pediatr. 2015 Aug 5; 41:55. doi: 10.1186/s13052-015-0161-3. PMID: 26242548; PMCID: PMC4526284.

[6]Sun M, Li N, Dong W, Chen Z, Liu Q, Xu Y, He G, Shi Y, Li X, Hao J, Luo Y, Shang D, Lv D, Ma F, Zhang D, Hua R, Lu C, Wen Y, Cao L, Irvine AD, McLean WH, Dong Q, Wang MR, Yu J, He L, Lo WH, Zhang X. Copy-number mutations on chromosome 17q24.2-q24.3 in congenital generalized hypertrichosis terminalis with or without gingival hyperplasia. Am J Hum Genet. 2009 Jun; 84(6):807-13. doi: 10.1016/j.ajhg.2009.04.018. Epub 2009 May 21. PMID: 19463983; PMCID: PMC2694973.

[disclaimer]

The data in this article was updated on May 14th, 2021.

It was originally written by Professor Yang Xichuan, a dermatologist, aiming at popularizing science for readers.

Popular science content can not replace doctors’ diagnosis and treatment opinions, and is for reference only.

If you have skin problems, please consult a doctor in time.

Some pictures are from the Internet. If there is any infringement, please contact to delete them.

Cover image source: blurrr

Read the original text

　　From the end of 2017 to the present, the most talked about hair may be the so-called "post-90 s hair loss". The amount of discussion on this topic in Weibo was so great that it caused so much resonance that we were surprised.

　　No matter whether the post-90s generation has entered the stage of collectively worrying about hair loss, this topic can attract the attention of the whole people, indicating that everyone’s attitude towards the phenomenon of hair loss is absolutely-no! Can! Endure!

　　Although it is said that "smart brains don’t grow hairy", once the A, B and C around them suffer from hair loss, it is not only a change in appearance, but also will become unconfident and depressed over time, which will affect their mood in the long run.

　　Even Xiao Lizi can’t accept the change of face value brought by the backward movement of hairline.

　　As we all know, the workplace pressure faced by Japanese men is enormous. A survey shows that young people and middle-aged people who work hard in the Japanese workplace will take the initiative to save their hair once they encounter the problem of hair loss, and a large number of them will choose hair transplant. This is because they think that hair loss will affect their development in the workplace.

　　It can be seen that hair loss is not only a phenomenon that affects appearance, but also a serious issue that will affect people’s career prospects and personality formation. Therefore, it is urgent to solve the problem of hair loss.

　　At present, in addition to surgical hair transplantation, it can be said that it is one of the effective and significant ways to solve the problem of hair loss, but first of all, the cost of hair transplantation is high, which is not acceptable to all people with hair loss; Secondly, the process of hair transplant surgery will also be accompanied by some pain; Finally, since it is an operation, there are also cases of risks and failures.

　　In addition to surgery, some anti-shedding/hair-growing shampoos are still the main methods for most people with hair loss. But the effect, it can be said that it is very general. Even if you come across some effective products, as an ordinary consumer, you are not sure whether the ingredients contain hormones or not, are you?

　　However, today, we want to tell you a good news-hair loss, and even all other hair problems you can imagine now, will be completely and fundamentally solved in the near future.

　　Xiaolang is not bragging because he dares to clap his chest like this to assure you. Because on April 3, local time in France, Xiaolang had the opportunity to participate in the 2018 Hair Summit held by L ‘Oré al Paris in Paris.

　　—————————— I am a serious and rigorous "science fiction" dividing line.

　　Here, we have the honor to see the research process of L ‘Oré al Paris Research Center on hair problems, understand their recent research directions and achievements, and bring you the prospect of hair care in 2050 (this vision has been confirmed by scientists to be completely achievable).

　　Now I’d like to show you the research results that scientists from L ‘Oré al Research Center in Paris have brought us, and their outlook on hair care in the next few decades.

　　Black Technology 1: Maintain the scalp and hair follicles healthy and orderly and solve the problem of hair loss.

　　So in 2050, what methods will we use to fundamentally solve the problem of hair loss? Scientists at the L ‘Oré al Research Center in Paris have given the answer-to maintain or increase the density of hair by keeping the scalp and hair follicles healthy and orderly.

　　By reactivating the hairs? Or extract hair follicles from other places and replant them into the scalp? On the other hand, how to reduce unwanted hair without destroying hair follicles? This will be their main research direction to fundamentally solve the problem of hair loss.

　　It can be predicted that by that time, we can completely control and activate hair follicles by scientific means, so we can not only make hair grow in hair follicles, but also remove unwanted hair? (Will anyone have this demand? Xiaolang, whose hair is worrying, said that he could not understand it, hahaha)

　　Black Technology 2: Synthesize nano-scale protein to repair damaged hair.

　　Do you think that solving the problem of hair loss is the greatest research achievement of scientists in L ‘Oré al Research Center? Then you are naive. At this summit, scientists also showed us that 30 years later, we will usher in such an era of hair care that seems completely unimaginable at present. protein is crucial to reverse the natural aging of hair, and in the future, plant-based bacteria will help us repair hair by synthesizing nano-scale protein (keratin-related protein), thus preventing hair from becoming dim or broken.

　　Not only can the damaged hair be fundamentally improved, but our daily hair care methods will also enter a brand-new "waterless era"!

　　In the future, there will be no need for water for hair washing and hair care. It is conceivable that there will be a water reprocessing station in everyone’s bathroom, and the efficacy of the product will become super lasting. At that time, there will be some ingredients that can be cultivated artificially. We will no longer explore the ingredients from the endless natural resources, but study these ingredients, and cultivate them artificially and from the perspective of sustainable development, and use them in production to achieve the effect of hair care.

　　Black technology 3: biotechnology controls hair color and bid farewell to white hair

　　In addition to hair care through technology, scientists at L ‘Oré al Paris Lab will also control hair through biotechnology. This can easily change the hair color, and then the so-called hair will turn white with human aging? There is no dear!

　　Well, after seeing the hair care methods in 2050, did you find it incredible for a while? But don’t think that this is just the result of brain opening. You know, this is a scientific conclusion given by scientists at the L ‘Oré al Research Center in Paris on the basis of continuous research and exploration in recent years.

　　The development and progress of science and technology will never exceed our imagination. I wish our hair can fight side by side with us until the day when the era of "big explosion of hair care technology" comes.

　　CCTV News:In order to improve people’s attention to chronic kidney disease (CKD), the International Society of Nephrology (ISN) and the International Foundation for Nephrology (IFKF) jointly designated the second Thursday of March every year as "world kidney day". March 14th, 2019 is the 14th world kidney day, and this year’s theme is "Kidney Health for All".

　　On March 17th, more than 200 leaders, nephrologists and medical staff, including Yang Min, Vice President of Chinese Medical Doctor Association, Jin Dapeng, Chairman of Nephrology Branch of Beijing Medical Association, Chairman of Nephrology Branch of Chinese Medical Doctor Association, and Academician Chen Xiangmei, Chairman of Nephrology Committee of China Society of Integrated Traditional Chinese and Western Medicine, gathered in national hotel, Beijing, and read out the "world kidney day Proposal in 2019" and started academic exchanges around this year’s theme.

　　"Everyone enjoys kidney health" aims to further raise people’s attention to the high burden and important harm of kidney diseases around the world, improve the prevention and management strategy of kidney diseases, and call for comprehensive health coverage, prevention and early treatment of kidney diseases. Encourage people to adopt a healthy lifestyle, screen high-risk groups, ensure that patients with kidney disease get the basic health services they need, such as basic physical examination, laboratory tests, and essential drugs, delay the progress of the disease as much as possible, and strengthen advanced health care capabilities to ensure the health of the whole people’s kidneys.

　　However, as one of Chinese’s favorite "tonic" organs, does the public really know about kidneys? Therefore, persistent popularization of popular science is the most important work for medical staff during their stay in world kidney day, which has been done by Beijing nephrologists for 14 years. Every year, through a large number of new media publicity, free clinics, doctor-patient friendship, knowledge lectures and other forms, medical common sense and knowledge of CKD prevention and treatment are popularized to the public, so that many Beijing citizens have obtained correct knowledge of kidney disease. On March 14th this year, on the same day in world kidney day, kidney disease experts from 16 hospitals in Beijing, including xuanwu hospital of Capital Medical University, Fourth Medical Center of the People’s Liberation Army and People’s Hospital of Peking University, walked into Luhe Hospital of Tongzhou affiliated to Capital Medical University and held free clinic and popular science publicity activities. The scene was very warm. "We issued a call to the whole country, and the kidney health of the people in the city and the kidney health of the people all over the country started from this! This is what Beijing experts should do, and it is also what Beijing experts have done well and have always insisted on doing. " Academician Chen Xiangmei affirmed the popular science work of kidney disease in Beijing in the past 14 years.

　　Is your kidney healthy?

　　Academician Chen Xiangmei said in his speech at this conference that this year’s government work report clearly puts chronic diseases at the national prevention and treatment level, and our theme this year, "Kidney health for all", is to extend from disease to the concept of great health, which is very macroscopic and in line with the pulse of the times, in line with the pulse of deepening reform of medical and health undertakings, and what we should do when we enter a new era.

　　At present, compared with cardiovascular disease and diabetes, the popularization of chronic kidney disease in China is not extensive enough, and the medical literacy of the general public needs to be improved. They lack the awareness of actively understanding medical common sense and fail to fully understand the knowledge of preventing kidney disease in time. Moreover, the problem of "expensive and difficult to see a doctor" still exists, which makes some patients fail to see a doctor in time or have regular physical examination. These are important reasons why chronic kidney disease is not easy to be found early.

　　If chronic kidney disease is not prevented early, the condition will gradually progress until uremia develops; It not only damages the health and labor ability of patients, but also brings great pain to patients and even endangers their lives; At the same time, it will also greatly increase the economic burden of patients’ families and society. In fact, the low rate of early prevention and control has brought serious consequences. About 20%-30% patients with kidney disease often find that the renal function damage has developed to an irreversible level when they first visit the hospital.

　　But how can the public judge whether their kidneys are healthy?

　　In fact, it’s very simple, just a simple physical examination. Urine protein and red blood cells in urine routine can basically provide clear signals related to kidney disease.

　　"The key to early interventional therapy is to insist on regular screening every year. Even if there are no symptoms, it is generally necessary to screen urine routine and renal function once a year. If you have hypertension, diabetes, etc., you should check it every six months as appropriate; If you already have certain symptoms, you should go to the hospital for a comprehensive physical examination as soon as possible. " This year’s brochure of world kidney day clearly points out the ways and means.

　　Prevention and treatment of kidney disease starts with healthy living.

　　In recent 30 years, with the improvement of living standards and working conditions of Chinese people, some changes have taken place in people’s traditional lifestyle, such as excessive intake of certain nutrients (carbohydrates, fat, salt, etc.) and reduced physical activity; At the same time, work stress, mental stress, lack of sleep, smoking, alcoholism, environmental pollution and other factors have increased the incidence of metabolic diseases such as hypertension, diabetes, hyperlipidemia, hyperuricemia and obesity, resulting in an increasing prevalence of chronic kidney disease. In addition, drug-induced renal damage caused by drug abuse or irregular use of drugs also showed a significant increase trend.

　　In the academic exchanges at the conference, Professor Li Yuehong’s "What kind of harm does beauty and hairdressing do to the kidney", Professor Tu Xiaowen’s "Smoking and drinking do harm to the kidney", Professor Li Zhongxin’s "The four high protections are not in place, and the kidney is not small", Professor Xiao Yuefei’s "I don’t care if I have a cold and fever, but my kidney is hurt by improper medication" and Professor Zhou Yilun’s "What should I do to protect my kidney" are all easy to understand from the perspective of daily life.

　　At present, the incidence of kidney disease in China is as high as 10.8%, and there are about 130 million CKD patients in China. Looking around the world, there are about 850 million people suffering from kidney disease in the world for various reasons. CKD causes at least 2.4 million deaths every year, and it is currently the sixth fastest growing cause of death.

　　Therefore, Academician Chen Xiangmei suggested that "the participation of the whole people should make people fully realize that CKD is a preventable and treatable disease, understand the characteristics of common diseases, be familiar with the basic knowledge of self-management of diseases, master the skills of healthy lifestyle, and gradually enhance the awareness of disease prevention. It is necessary to change unhealthy lifestyles such as overeating, smoking, excessive drinking and lack of exercise, and prevent and control obesity, hyperlipidemia, hypertension, hyperglycemia, hyperuricemia and abuse.

　　At the same time, experts attending the meeting also called on the whole society to pay more attention and help to CKD patients in spirit, psychology, work, family, economy and life, and strive to gradually realize the beautiful vision that everyone can master medical common sense and enjoy healthy kidneys.

This Sunday (September 1st),

Qingdao people’s long-awaited "opening the sea" will come as scheduled.

Where can I buy the freshest and cheapest seafood?

How to go, how to choose

Come on, take what Qingbaojun has carefully arranged for everyone.

Let’s go with this "sweeping goods" strategy.

Where to buy it

Market article

Tuandao market

Tuandao Farmers’ Market, located near No.5 Taixi No.1 Road in Shinan District, is becoming more and more "tall". In the seafood stall on the first floor, many fresh seafood can be seen everywhere, including abalone and lobster. Tourists who like seafood are suitable to live around here. Buy some seafood and go to a restaurant for processing. It’s cheap and fresh.

Nanshan market

The biggest feature of Nanshan Market, located in Sangzi Road, Shibei District, is that the goods are complete, and fish, shrimps, crabs and all kinds of seasonal seafood can be found there, saving time and effort.

Dalian road market

Dalian Road Market, located in Dalian Road, Shibei District, also has a variety of seasonal seafood such as fish, shrimp and crabs, which are affordable and fresh. It is also recommended that tourists who want to taste seafood buy it here and find a restaurant to process it!

Wharf article

Shazikou fishing port

As the largest fishing port in the city, Shazikou National Fishing Port in Laoshan District is mainly for merchants to wholesale, with complete varieties and sufficient supply.

Qingshan fishing village

Most of the berths at Laoshan Castle Peak Wharf are working boats, usually fishing in the offshore. These fishing boats are sold directly on the dock all the year round, but because of the tidal changes, the time of the daily sea goods market is not fixed.

Gangdongyu wharf

Gangdong Wharf is located in Wanggezhuang Street, adjacent to Yangkou Scenic Area. It is the second largest wharf in Laoshan District after Shazikou National Fishing Port and is rich in little seafood. Self-driving friends take Binhai Avenue, turn right after seeing the sign of "Wanggezhuang" and navigate "Gangdong Fishing Wharf". There is a seafood market every day in the local area. According to the change of tide, the landing time of fishing boats is not fixed.

Shazikou fishing village

Shazikou, Laoshan Mountain, still retains the original ecological fishing village. Fishermen fish offshore every day and sell them on the dock in the afternoon. little seafood with local characteristics is delicious. The catch is mainly yellow croaker, blackhead and sand board, and a small amount of shrimps, tigers, red crabs and small swimming crabs are also caught. Because it is pure wild and delicious, many citizens will go to the dock to find sea goods, and a few small miscellaneous fish will be brought home, cooked at home and delicious.

Jimiya fishing port

Self-driving friends go to Jimiya, go straight on Binhai Avenue after getting out of the tunnel, and navigation can directly search for "Jimiya Fishing Port". On the shore of the fishing port is the seafood market, where the newly landed seafood will be distributed. The local specialty Lingshan Island wild crab must not be missed.

Gujiadao fishing village

Gujiadao, one of the oldest fishing villages in Qingdao, is located on the south bank of Tangdao Bay, with beautiful scenery. Fishermen go out to sea on the same day, and after harvest, they will be sold directly on the pier at the head of the village, which is cheap and good.

Ride guide

Buy sea cargo bus routes

Gangdong Wharf: Take Bus No.616, get off at Gangdong Community and walk for 1000 meters;

Conference dock: Take bus No.616 (Yangkou-Qinjiatuzhai) and get off at Wangshankou East for the dock;

Yangkou Wharf: No.618 gets off at Quanling Station and goes to Yangkou Wharf;

Huangshan Wharf: Take bus No.618 and get off at Huangshan Station and go to Huangshan Wharf;

Castle Peak Wharf: Take bus No.618 and get off at Castle Peak Station for 10 minutes to reach the pier;

Jimiya Wharf: Take Tunnel No.7 and No.8 to Wuyue Square (sunny and sunny) Station in Xincheng, and then transfer to Bus No.27 in Development Zone and get off at Jimiya Station;

Zhaike Wharf: You can take bus No.7 and No.8 of Tunnel to Lingshanwei Hub Station, transfer to No.307 of Development Zone, and get off at the terminal. Or take the Qingxi Express to the West Coast Bus Terminal at the terminal, and then get off at the No.101 terminal in the Development Zone;

Chengyang Aquatic Products Wholesale Market: Take Bus No.767 and get off at Jincheng Road Station;

Shangma Daji: Take Bus No.774 to Shangma Parking Lot and get off at Shangma Parking Lot Station;

Hetao Daji: Take Bus No.774 and get off at Xihetao Station;

Chaidao Port Pier: Take Bus No.674 and get off at National Deep Sea Base Station;

Xifu Town Farmers’ Market: Take bus 673 and get off at Xifu Town Station.

Old Qingdao taught you to pick seafood like this.

Pick a shrimp and tiger

The one with the white "Wang" on the neck is female, and the third pair of feet of the shrimp and tiger is male with a calf. The female has a smaller body and a thinner neck.

Pick shrimp

1. Look at the speed: live shrimps raised in the water swim as fast as possible when fishing with nets;

2. Look at the color: the fresh shrimp body surface and abdominal limbs are not black, the head and surface are not red, the shrimp shell is hard, and the shiny meat is more delicious;

3. Look at the tightness: it depends on the tightness between the shell and the muscle. The fresh shrimp is very tight between them, and it is not easy to peel it off by hand, but if it is a long-standing shrimp, it will be easily peeled off by hand;

4. Look at spitting bubbles: it is a quiet observation. Fresh shrimps will spit out bubbles from time to time, indicating that they have normal life breathing;

5. Smell: Shrimp has a fishy smell, and the more fishy it is, the fresher it is.

Pick fish

1. Fresh fish eyes are shiny, complete and slightly protruding, and there is no congestion and redness around them;

2. The gill color of fresh fish is bright red or pink, the gill cover is closed, the mucus is less transparent and has no peculiar smell;

3. There is less mucus on the skin of fresh fish, and the body surface is clean; Fish scales are tight, complete and bright; Press it with your finger to loosen it, and the depression will be flattened immediately; There is a round pit around the anus, hard and white, and the abdomen does not swell.

Pick crabs

1. Look at the male and female: the male abdomen is triangular and the female is semicircular. This is the simplest method.

2. Look at the leg fluff: the fluffy and hard indicates that it is strong and fleshy, but it is weak and meatless;

3. Look at vitality: it can be turned over, and it can be turned over quickly to show that it is very healthy. If it cannot be turned over, it means that vitality is not strong;

4. It depends on the hardness of the abdominal shell at the top of the crab navel: squeeze it with your thumb, which means that the meat is thick;

5. Weigh the weight: If two of the same size are weighed by hand, which one weighs more meat.

Pick shellfish

1. Look at the water: most merchants will keep it in water. If the water is turbid and there is a lot of sludge, it means it is not fresh. The water is relatively clear and generally fresh;

2. Look at the head: the big meat is thicker and chewy; Small size has less impurities;

3. pick slowly: each one must make sure that the tongue sticks out and can be retracted by touching it with your hand, indicating that it is fresh.

Pick oysters

Fresh and good quality oysters, full or slightly soft, milky white, clear body fluids, white or light gray, with the inherent smell of oysters. Poor-quality oysters are dark in color, turbid in body fluids, and have a strange smell, so they cannot be eaten.

Tips

Eating seafood in autumn, these taboos should be known.

★ Uncooked seafood contains bacteria. Generally speaking, it takes 4-5 minutes to cook in boiling water to be completely sterilized.

★ There are many toxins in dead shellfish. Once shellfish die, they multiply germs and produce toxins. Therefore, it is best to buy shellfish alive, buy them now and eat them now!

★ Seafood and beer cause gout with the same food. Seafood such as shrimps and crabs will form uric acid after metabolism, and excessive uric acid will cause gout, kidney calculi and other diseases.

★ Eating seafood and fruits together will cause abdominal pain. If eaten with persimmon, grape, pomegranate and hawthorn, it will irritate the gastrointestinal tract and even cause abdominal pain, nausea and vomiting. Therefore, seafood should be eaten with these fruits at least 2 hours apart.

★ Drinking tea after eating seafood leads to stones. It’s best not to drink tea when eating seafood. In the same way, it is also best to have an interval of more than 2 hours.

Crab, tiger, jellyfish, Spanish mackerel, snakehead, conch,

Oyster, hairy clam, scallop, sea rainbow …

They are coming!

Make an appointment with your foodie friend to sweep the goods ~

▍ Source/intranet ▍ Author/Bai Yu

Up nearly 30%! Beijing stands out from the rest, selling cardiovascular and cerebrovascular diseases, tumors and respiratory systems.

In recent years, Chinese medicine industry policies have been introduced frequently, and it has been more favorable since this year. In February, the General Office of the State Council issued the Notice on Several Policies and Measures for Accelerating the Development of Traditional Chinese Medicine. In June, National Medical Products Administration launched ten key research projects, including the research on the effectiveness and safety evaluation of traditional Chinese medicine and the whole process quality control. Real-world data support the research on evaluation methods of traditional Chinese medicine, rare disease treatment drugs, innovation and clinical urgently needed medical devices; National Health Commission and other three departments issued the Opinions on Further Strengthening the Work of Traditional Chinese Medicine in General Hospitals and Promoting the Coordinated Development of Chinese and Western Medicine. On July 7th, official website City, state administration of traditional chinese medicine issued the notice of "Implementation Plan of Traditional Chinese Medicine Cultural Communication Action (2021-2025)", which proposed four key tasks, such as deepening the essence of traditional Chinese medicine culture, so as to further integrate traditional Chinese medicine into public life. According to industry insiders, the Chinese medicine industry continues to usher in favorable policies. While optimizing the industry structure, accelerating inheritance and innovation is conducive to going abroad and further promoting the development of the Chinese medicine industry.

Quarterly sales of Chinese patent medicines in key cities from 2020 to 2021 Q1

Source: terminal competition pattern of Chinese patent medicines in public hospitals in key cities

According to the data of Minenet, in 2020, the sales of proprietary Chinese medicines in public hospitals in key cities will be nearly 30 billion yuan, down more than 10% year-on-year. Judging from the quarterly sales trend, the market gradually picked up after experiencing the low tide in the first quarter of last year, and rose by 29.33% in the first quarter of this year.

Urban Pattern of Chinese Patent Medicines in Public Hospitals of Key Cities in 2021Q1

Source: terminal competition pattern of Chinese patent medicines in public hospitals in key cities

Judging from the urban pattern, Beijing stands out, with sales of nearly 1.8 billion yuan; The sales of Zhengzhou, Chongqing and Guangzhou all exceeded 800 million yuan. From the perspective of TOP20 manufacturers, Zhejiang Kanglaite Pharmaceutical, Yangzijiang Pharmaceutical Group, Shanghai Green Valley Pharmaceutical, Hangzhou Zhongmei Huadong Pharmaceutical and Jichuan Pharmaceutical Group are in the top five; The sales growth rate of Lunan Houpu Pharmaceutical, Tibet Qizheng Tibetan Medicine and Jiangsu Kangyuan Pharmaceutical all exceeded 50%.

From the perspective of large-scale pattern, drugs for cardiovascular and cerebrovascular diseases, drugs for tumor diseases and drugs for respiratory diseases are the hottest, accounting for more than 55% of the total market share; Drugs for musculoskeletal diseases, drugs for pediatrics, drugs for invigorating qi and enriching blood, etc. increased by more than 50%.

The Yangtze River and Jichuan … 16 exclusive products "preempted" TOP20, and 4 products rose by over 30%.

TOP10, a Chinese patent medicine product in public hospitals of key cities in 2021Q1

Source: terminal competition pattern of Chinese patent medicines in public hospitals in key cities

Among TOP20 products, except Shuxuening injection, cinobufotalin capsule, Xingnaojing injection and Tongguanteng injection, 16 products such as Kanglaite injection, Danshen Polyphenolate for injection, Jinshuibao tablet, Suhuang Zhike capsule and Pudilan Xiaoyan oral liquid are exclusive products, involving Zhejiang Kanglaite Pharmaceutical, Shanghai Lvgu Pharmaceutical, Jiangxi Jimin Kexin Pharmaceutical, Yangzijiang Pharmaceutical Group Beijing Haiyan Pharmaceutical, Jichuan Pharmaceutical Group and other manufacturers. In terms of dosage forms, injections account for 60%. From the perspective of treatment categories, cancer diseases are the most commonly used drugs, with 5 drugs; Followed by drugs for cerebrovascular diseases, there are 4; There are three drugs for cardiovascular diseases and three drugs for strengthening waist and strengthening kidney respectively.

From the perspective of sales growth, more than 80% of TOP20 products have positive growth, among which Tongguanteng injection has the fastest growth rate, and cinobufotalin capsules, Xueshuantong for injection (freeze-dried) and Jinshuibao tablets all exceed 30%. It is worth mentioning that only three of the TOP20 products in 2020 are positive growth.

Quarterly sales of Jinshuibao tablets in public hospitals in key cities from 2020 to 2021 Q1 (unit: 10,000 yuan)

Source: terminal competition pattern of Chinese patent medicines in public hospitals in key cities

Jinshuibao tablets are the exclusive products of Jiangxi Jimin Kexin Pharmaceutical. According to the data of Minenet, the sales of Jinshuibao tablets in public hospitals in key cities have increased rapidly in recent years, from less than 50 million yuan in 2017 to more than 400 million yuan in 2020. The sales in the first quarter of this year have exceeded 100 million yuan, a year-on-year increase of 31.02%.

Quarterly sales of Tongguanteng injection (Xiaoaiping injection) in public hospitals in key cities from 2020 to 2021 Q1 (unit: 10,000 yuan)

Source: terminal competition pattern of Chinese patent medicines in public hospitals in key cities

Tongguanteng injection (Xiaoaiping injection) is used for the treatment of esophageal cancer, gastric cancer, liver cancer and other tumors, and is combined with radiotherapy and chemotherapy as adjuvant treatment. According to the data in the Minenet, in 2020, the sales of Tongguanteng injection (Xiaoaiping injection) in public hospitals in key cities exceeded 200 million yuan, up 2.25% year-on-year; The first quarter of this year increased by more than 50% year-on-year. At present, the only manufacturers of this product are Nanjing Shenghe Pharmaceutical and Tonghua Jinma Pharmaceutical Group, among which Nanjing Shenghe Pharmaceutical has the largest market share.

The policy is good! Renfu, Kangyuan, Yiling … Class 1 new drugs launched an impact.

Since 2020, a total of six Chinese patent medicines have been approved for listing. Among them, Lianhua Qingke Tablet is a 6.1-class new Chinese medicine developed by Yiling Pharmaceutical under the guidance of collateral disease theory of traditional Chinese medicine for treating acute tracheobronchitis. Jingu Zhitong Gel is a 6.1-class new Chinese medicine developed on the basis of the clinical experience of Professor Sun Shuchun, an orthopedic expert at China Academy of Traditional Chinese Medicine. Kangyuan Pharmaceutical has independent and complete intellectual property rights of this new medicine. The total alkaloid tablets of Ramulus Mori from Beijing Wuhe Boao Pharmaceutical Co., Ltd. are used to treat type 2. In the first half of this year, Qingfei Detoxification Granule of Institute of Clinical Basic Medicine of Chinese Academy of Traditional Chinese Medicine, Huashi Detoxification Granule of Guangdong Yifang Pharmaceutical and Xuanfei Detoxification Granule of Shandong Buchang Pharmaceutical were approved for listing.

Application for listing of Class I new Chinese patent medicines since 2020

Source: Minenet MED2.0 China Drug Evaluation Database.

In addition, since 2020, a total of 13 Chinese patent medicines have been submitted for listing, among which 10 are Class I new drugs, including Yinqiao Qingre Tablet of Jiangsu Kangyuan Pharmaceutical, Jingule Tablet of Hunan Fangsheng Pharmaceutical, Kunyining Granule of Tasly, Su Xia Jieyu Bufan Capsule of Yiling Pharmaceutical, etc. A few days ago, the total flavonoids capsule of Desmodium styracifolium was submitted to the market as a new class 1.2 Chinese patent medicine and was undertaken by CDE. At present, it is under review and approval, and it is expected to become the first new class 1 Chinese patent medicine in Renfu in recent ten years.

Liam Neeson talks to the mystery man with a serious face.

1905 movie network news A few days ago, the action suspense film has met the audience in North America. The action scenes of life and death and the suspense reversal of wits have made the film gain excellent box office results and word of mouth after its release. With a series of films, liam neeson, who successfully created the screen to "rescue professional households", once again "returned to his old job". As an ordinary white-collar uncle, he was not only accidentally involved in a conspiracy, but also single-handedly searched for a mysterious passenger on the commuter train in new york and eliminated the danger, which was exciting and suspenseful.

The Commuter tells the story of Macaulay, the hero played by liam neeson, who meets the mysterious girl Joanna on his way home by commuter train in new york. Joanna offered Macaulay a tempting task — — Find out a passenger in the car and get a huge sum of cash in return. But in the process of searching, Macaulay gradually found himself not only involved in a deadly conspiracy, but also unable to quit, and a rescue operation full of suspense and excitement began. When the commuter train close to everyone’s life scene becomes a runaway and deadly journey, how Uncle Liam can solve the puzzles lurking in the commuter train and rescue the passengers is expected.

Liam Neeson turned into a white-collar uncle, running for his life.

With a series of screen roles to rescue relatives in distress, liam neeson deserves to be a "rescue specialist" in Hollywood. In Taken3 series films, he plays a retired agent who chases across many countries and rescues his daughter and wife from foreign evil organizations. Whether it is a sharp and professional lynching trial or a quick skill of one enemy and ten, the image of a loving father who is eager to save a woman and the fierce domineering of fighting violence with violence have made him numerous; In the movie, liam neeson, who plays the plainclothes air marshal, changed the battlefield again, fighting wits and wits with the hijackers lurking among the passengers at high altitude, reversing Gan Kun in the air at the peak of 10,000 meters, finding out the black hand behind the scenes from the clues, and at the same time, fighting hand-to-hand in the narrow cabin to rescue the passengers of the whole plane … …

It can be said that with a series of invincible rescue operations, Uncle Liam not only successfully created an IP movie with the theme of "rescue", but also made himself a leading figure in Hollywood action heroes and won fans all over the world to call him crazy.Different from films such as Taken3 and NON-STOP, the role played by liam neeson in The Commuter no longer has the aura of skills such as special agent and air marshal, but becomes a white-collar office worker. Playing an ordinary person in an action movie for the first time, he not only had to make a living, but also struggled with the complicated and demanding needs of his boss and customers. At the age of 60, he lost his job and lost his direction in life, and he didn’t know how to face his family and future. It is a challenge for talented liam neeson to play such an ordinary middle-aged man who is involved in a life-and-death rescue operation at the same time. In the film, liam neeson, who was laid off, was lured by the mysterious girl into a gambling conspiracy because of the pressure of life.

Liam neeson moved the wrench to rescue the commuter train.

Jaume serra, the director who has cooperated with liam neeson for four times, praised Uncle Liam’s performance. He recalled his experience in shooting The Commuter, saying, "Every day when shooting, I am like a child looking forward to a Christmas present, waiting for the performance surprise brought by Nelson. His style and his eyes, he can completely change and create new roles with various nuances."

Not only is it more interesting in acting, but the action scene of the film is also thrilling. In the closed tense and high-speed train space, liam neeson should not only race against time to crack the true identity of the man behind the scenes, but also use all props in the train to fight, constantly resolve the dangerous ambushes and rescue the passengers on the train. The gradual reversal of the plot and the rapid and sharp action scenes have all upgraded The Commuter’s performance and action scenes.

In addition to liam neeson, the film The Commuter also featured famous Hollywood movie stars Vera Farmiga, Patrick Wilson and sam neill, and was directed by NON-STOP’s Hollywood genius jaume serra. The film has been released in North America and is expected to be introduced to Chinese mainland in 2018.