Dr. Guan Kang Kang You from the Department of Nuclear Medicine talks about thyroid gland.

1. What is pepsinogen?

Pepsinogen (PG) is the precursor of pepsin. According to its biochemical properties and immunogenicity, it can be divided into two subgroups. The immunogenicity of 1~5 components is the same, and it is called Pepsinogen I (PG I), which is mainly secreted by the main cells of gastric fundus gland and mucus neck cells. Components 6 and 7 are called pepsinogen Ⅱ(PGⅡ), which can be secreted by the main cells and mucus neck cells of gastric fundus gland, and also produced by mucus neck cells of pyloric gland of cardiac gland and gastric antrum and upper duodenum.

Usually, about 1% PG enters the blood circulation through the capillary of gastric mucosa, and the PG entering the blood circulation is very stable in the blood. Serum PG ⅰ and PG ⅱ reflect the number of glands and cells in gastric mucosa, and indirectly reflect the secretory function of different parts of gastric mucosa. When pathological changes occur in gastric mucosa, the content of serum PG also changes. Therefore, monitoring the concentration of PG in serum can be used as a means to monitor the status of gastric mucosa.

Detection of pepsinogen (PG), an early warning indicator of gastric cancer

1. Chronic atrophic gastritis is an important "transitional event" in gastric mucosa canceration.

Gastric cancer is one of the common malignant tumors in China, and its mortality ranks first among all kinds of malignant tumors. Its early diagnosis and early treatment have become the only way to improve the quality of life of patients and reduce the mortality. At present, the main methods for diagnosing gastric cancer are fiberoptic gastroscopy and upper gastrointestinal radiography, among which gastroscopy is called the "gold standard" for diagnosing gastric cancer.

At present, it is believed that partial atrophy can be reversed, and once it enters intestinal metaplasia, it is difficult to reverse it. Therefore, there is an urgent need for a tool that can keenly detect the atrophy of gastric mucosa. At this time, the detection of pepsinogen plays a powerful role.

When the gastric fundus gland atrophied, the number of main cells decreased and the level of PG ⅰ decreased. However, because there are more cells secreting PG ⅱ, PG ⅱ can still maintain a high level at this time, and the ratio of PG ⅰ to PG ⅱ decreased significantly. When atrophic gastritis is accompanied by intestinal metaplasia and gastric antrum gland extends to the stomach body, and pseudopyloric metaplasia of gastric fundus gland occurs, the level of PG ⅱ increases more, and the ratio of PG ⅰ to PG ⅱ decreases further. Therefore, the decrease of PG ⅰ level is a reliable sign of gastric fundus gland mucosa atrophy, and PG ⅰ/PG ⅱ profile reflects the degree of gastric fundus gland mucosa atrophy.

2. Helicobacter pylori infection is the initiating factor for the development of gastric cancer.

The occurrence of gastric cancer is the result of multiple factors. The multi-step hypothesis of gastric cancer, that is, from chronic non-atrophic gastritis (formerly known as chronic superficial gastritis) → atrophic gastritis → intestinal metaplasia → intraepithelial neoplasia (formerly known as dysplasia) → gastric cancer, has been generally accepted. Helicobacter pylori (Hp) infection has become the most important initiating factor, and Hp infection has been recognized as an independent risk factor for gastric cancer.

Therefore, active detection of Hp has become one of the important measures to prevent and treat gastric cancer. Hp detection is mainly divided into invasive and non-invasive methods. For Hp-positive infected people, the major guidelines have reached a consensus that Hp infection-related gastritis is an infectious disease and it is recommended to eradicate it.

Hp infection can also significantly affect the serum PG level. At the beginning, PG ⅰ and PG ⅱ both increased, and the increase of PG ⅱ was faster, then PG ⅰ/PG ⅱ decreased, and the larger the Hp infection focus, the greater the decrease of PG ⅰ/PG ⅱ. However, the results of pepsinogen test are lack of specificity, and special Hp test is still needed to judge whether Hp is infected or not.

Third, pepsinogen Ⅰ(PGⅠ),

The results of pepsinogen Ⅱ(PGⅡ) were analyzed as follows:

Four, "pepsinogen" test results misunderstanding:

Myth # 1: If only PG ⅰ is measured during physical examination, nearly 70% of the results are in the range of 40~70ng/mL, which seems to be lower than 70ng/mL on the surface, and gastric atrophy is suspected, but the results are difficult to explain because PG ⅱ and ratio are not measured. When PGⅡ is retested, the ratio of more than 90% is greater than 3. This kind of situation is due to the high incidence of chronic superficial gastritis in China population, which belongs to normal physiological gastric acid secretion insufficiency.

Myth 2: PG-positive means "stomach cancer theory": positive means people at high risk of stomach cancer. PG project is a simple screening project for gastric cancer in the early stage of physical examination, replacing X-ray and ultrasonic screening for gastric cancer. The main significance lies not in diagnosis but in early detection and prevention. Normal people are 15%PG positive, and those with PG positive have a high risk of developing gastric cancer, and the early detection rate of gastric cancer is 1%~2%.

Myth # 3: Pay attention to the change of reference range values of PG ⅰ and PG ⅱ, but not the ratio. Because the secretion of PG ⅰ in gastric mucosa changes greatly (above 70~800ng/mL) under the attack of inflammation, the secretion of PG ⅱ is relatively constant. When comparative value > 3, the degree of PG ⅰ increase can only be combined with clinical analysis to determine the type of gastric diseases. When comparative value < 3, it is suggested that further in-depth endoscopy or pathological sampling should be taken to confirm and warn the high risk of early gastric cancer, and follow-up monitoring should be carried out in the last five years. The incidence of gastric cancer was 2% in PG-positive patients who had no gastric cancer in the same year and in the following five years.

Five, Japan’s experience for reference ("ABC" method+endoscopic screening)

Our neighbor Japan, as a country with high incidence of gastric cancer, has done a very good job in early cancer screening. Their screening strategy for early cancer firmly grasps the two controllable factors of Hp infection and whether gastric fundus gland atrophy occurs.

The Kyoto Consensus of Japan made the following recommendations for the national early cancer screening strategy: first, for Hp infection, the Kyoto Consensus emphasized "shoot to kill", and after everyone sterilized and eradicated Hp, PG was evaluated. The ratio of PG ⅰ/PG ⅱ is ≤3.0, which is regarded as the critical diagnostic value of atrophic gastritis, and as the screening standard of high-risk population of gastric cancer.

Vi. A Long Way to Go-Strategies for Early Cancer Screening in China;

China has a large population base and the incidence of gastric cancer remains high, so it is imperative to find a simple, accurate and effective screening method for gastric cancer. In 2017, the China Consensus on Chronic Gastritis highly affirmed the value of PG, and the guidelines gave the following recommendations: The detection of serum pepsinogen (PG) ⅰ and ⅱ and gastrin -17 may help to judge whether there is gastric mucosal atrophy and its degree. Detection of serum PG ⅰ, PG ⅱ, PG ⅰ/PG ⅱ ratio combined with anti-Hp antibody is helpful for risk stratification management.

The Expert Consensus on Early Gastric Cancer Screening Process in China, published at the end of 2017, not only affirmed the value of serum PG, but also put forward a new gastric cancer screening scoring system, in which the elderly, male, Hp antibody positive, low pepsinogen ratio (PGR) and high serum 17(gastrin-17 (G-17) level are high risk factors for gastric cancer.

Among them, G-17 is a new item in China Guide. G-17 is an amidated gastrin synthesized and secreted by G cells in gastric antrum. Its main physiological function is to stimulate gastric acid secretion and promote the proliferation and differentiation of gastric mucosal cells. G-17 is one of the sensitive indexes to reflect the endocrine function of gastric antrum, which can indicate the atrophy of gastric antrum mucosa or whether there is abnormal proliferation. G-17 itself can also promote the occurrence and development of gastric cancer. When the serum G-17 level rises, it may indicate the risk of gastric cancer.

In addition, different from the Kyoto consensus, the consensus in China put forward the critical value of serological detection for the first time, that is, when PGR<3.89 and G-17> 1.50pmol/L, the risk of gastric cancer increased significantly. The critical value of PGR defined by Kyoto Consensus is ≤3.

According to the score, the guide divides the population into three groups: low risk, medium risk and high risk, and gives the screening strategy.

At the same time, however, we should also see the shortcomings of the China guidelines. The screening population is over 40 years old, and there are other risk factors such as high incidence area of gastric cancer, Hp infection, previous precancerous diseases of gastric cancer, first-degree relatives of gastric cancer patients, diet and so on. However, at present, the onset age of gastric cancer is getting earlier and earlier, and I believe it will definitely enter prospecting stage in the future.

To sum up, serum PG combined with Hp detection is helpful to evaluate the risk of gastric cancer, and can be used as a routine screening method for gastric cancer for ordinary people. However, it cannot replace gastroscopy, and gastroscopy is still strongly recommended for high-risk groups.

Original title: Clinical Significance of Detection of Pepsinogen (PG)

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News from The Paper, Hebei, one of Gree Electric’s important markets, has suffered an unexpected change just as air-conditioning enterprises are preparing for the new freezing year.

It is reported that Hebei Xinxing Gree Electric Sales Co., Ltd. (Hebei Gree), a distributor in Gree Electric, issued a notice on August 18th, saying that on August 16th, Gree Electric suddenly stopped the delivery of goods to Hebei Gree, and asked the distributors who had invested money to plan and pick up the goods as soon as possible.

Just four days after Gree Electric cut off the supply of Gree in Hebei, on August 20th, Xu Zifa, the chairman of Hebei Xinxing Gree Electric Sales Co., Ltd., hosted a banquet for the mainstream distributors in Shijiazhuang five-star hotel, and announced at the meeting that he would quit the operation of Gree from today! At the same time, he promised to give everyone a reassurance, and the dealer’s payment, rebate and anwei fee will be cashed for everyone.

According to a reporter from The Paper who learned from an insider, the details of "Moutai that was drunk for 15 years that night, and 100,000 cash was distributed to 10 people at each table" were true. Xu Zifa also thanked the dealer for his support for so many years.

On August 23rd, a reporter from The Paper called Hebei Gree, and the staff who answered the phone said "there is no obligation to answer whether the company will continue to sell Gree air conditioners" and "if you want to buy Gree air conditioners, the market is everywhere".

Gree Electric also chose to play it cool. As of press time in The Paper, Gree Electric has not responded positively to this matter.

However, The Paper reporter learned from a number of people in the home appliance industry that Gree Electric really fell out with Hebei Gree. Next, Gree Electric will re-establish distribution channels in Hebei.

Some media reported that after Gree stopped supplying to the general distributor in Hebei, Gree Zhuhai Headquarters sent a 50-member marketing team to Hebei, bypassing the original general distribution of Gree in Hebei and contacting local agents. The Paper reporter also learned from insiders that the situation is basically true.

The strength of Hebei Gree should not be underestimated.

Hebei Xinxing Gree Electric Sales Co., Ltd. is one of the most powerful distributors in Gree Electric. Jinghai Internet Technology Development Co., Ltd. (Jinghai Internet), which was established by Hebei Gree and more than a dozen Gree Electric distributors, is an important shareholder of Gree Electric. As of the first quarter of this year, Jinghai Internet holds 8.34% of the shares of Gree Electric, ranking the third largest shareholder.

Tianyancha information shows that Hebei Gree indirectly holds 28% of the shareholders of Jinghai Internet and is also the largest shareholder of Jinghai Internet.

However, on June 24th this year, Gree Electric announced that it had received the Notice of Share Reduction from Jinghai Internet, a shareholder holding more than 5% of the shares. On June 24th, 2022, Jinghai Internet reduced its shareholding by 110,219,217 shares, accounting for 1.86% of the total share capital of Gree Electric, and cashed in 3.5 billion yuan. After the reduction, the shareholding ratio of Jinghai Internet decreased to 6.47%.

More importantly, as a major distributor in Gree Electric, Xu Zifa is also an investor in Philips Air Conditioning, which may also be one of the reasons for the deadlock between the two sides.

On August 9th this year, at the new product launch conference held by Philips Air Conditioning, Huang Hui, the former CEO of Gree Electric, appeared as the chairman of Philips Air Conditioning, Vinfom Hu, the assistant to the former president of Gree Electric, became the president of Philips Air Conditioning, and Xu Zifa attended the meeting as the shareholder representative of Philips Air Conditioning.

Gree turned into a competitor of Gree, which obviously angered Gree.

Liu Buchen, a senior home appliance observer, said in an interview with a reporter from The Paper that Gree Electric must be very dissatisfied with this practice of Hebei Gree. Before that, Gree Electric asked the dealer to choose one, and if he wanted to represent Gree, he could not represent Philips.

"Hebei Gree has both active and passive factors in doing so. Passive factors Gree Electric has promoted channel transformation in recent years, and the proportion of online sales has become higher and higher, which has affected the interests of traditional dealers and forced them to seek new ways out; However, investing in Philips is definitely the initiative of Hebei Gree. Considering so many years of experience and resources, I will try Philips air conditioning. " Liu Buchen said that he is not optimistic about the future prospects of Philips Air Conditioning and will not pose a threat to Gree.

However, Liu Buchen believes that it will take time for Gree to change the Hebei channel and find a suitable candidate, which may have a negative impact on Gree’s local sales.

However, the Hebei dealer incident did not bring much pressure to Gree Electric’s share price. On August 23rd, Gree Electric closed at 30.23 yuan, a decrease of 0.85%. The total market value of Gree Electric is 170.2 billion yuan.

Original title: Drink Maotai and discover gold! Xu Zifa took the lead in Hebei dealers and announced that he would quit Gree and went to Philips.

　　Famous Director & Actor Ying Da:It is impossible to judge the quality of comedy reality show according to a standard. I laugh when I can laugh. I think the level of domestic comedies is comparable to that of foreign comedies at this stage, because there are no sitcoms in China and cross talk in foreign countries. All the good comedies in foreign countries are in sitcoms, while the better comedies in China are kept in cross talk, and there is almost no second form. The skits are not at all. The farce is a new kind of drama and there is no chance.

　　

　　Liu Jianli, producer of Hunan Satellite TV’s "We All Love to Laugh":In fact, we can’t strictly define comedy, but no matter how the form of comedy changes, its core remains the same, that is, how to amuse the audience. I think it is most important to amuse the audience, whether it is the traditional comedy mode or the innovative performance form. At present, there is no complete training model for comedy talents in China. But as far as our program is concerned, the cultivation of talents is divided into two parts: external force and internal brain. External force is to learn from the mature experience of developed countries and carry out professional training; The inner brain means that in the process of making a program, the director and staff will sum up their own experiences in order to perform better.

　　

　　Famous crosstalk actor Degang Guo:It is said that crosstalk is within the scope of comedy, and comedy is still related to my major. My ability is average, but I can make do with it. I can still complete the task as a tutor.

　　

　　Song Weicai, Associate Professor, School of Art and Media, Beijing Normal University:The phenomenon that China variety shows follow the trend and rush headlong into action has a long history. However, the audience of the programs with the same theme may only pay attention to two or three files, and most of the follow-up works will soon disappear. Compared with music talent shows, comedy shows are actually more difficult to do, and it is more difficult for the market to support multiple programs, because in addition to players and tutors, it must also have enough original works. A newly created song can be sung many times and by different singers on different occasions. Once a comedy "Bao" is used once, it is difficult to use it in other comedies. This requires that these comedy columns or all kinds of comedy creative teams supporting these columns must have strong program originality, which is what the literary and art circles lack most at present. The lack of language programs in the Spring Festival Evening of the Year of the Horse is the most direct manifestation of this lack of originality.

　

　　Netizen Ameng:If China TV variety shows don’t make efforts to eradicate this homogeneity and change this morbid prosperity and vicious competition, they will eventually become monotonous and exhausted, which will only disgust the audience and lose their support.

　

　　China Economic Net Xiaobian has something to say:This round of comedy variety shows is also striving for dislocation competition. For example, some programs are more professional, while others mainly build grassroots players. Some of them are mainly complete comedies, while others are small performances of tens of seconds. However, the pressure of audience competition and the lack of innovation ability have made various TV stations afraid to take risks on the theme. The homogenization of China TV variety shows has not changed at all in this round of comedy trend.

　　CCTV News:According to the website of China Banking and Insurance Regulatory Commission, China, recently, the Consumer Protection Bureau of China Banking and Insurance Regulatory Commission, China issued the Notice on the Complaints about Insurance Consumption in the Second Quarter of 2022 (No.11 Notice of 2022, hereinafter referred to as the Notice), which informed the complaints about insurance consumption received and transmitted by China Banking and Insurance Regulatory Commission and its dispatched offices.

　　According to the Circular, China Banking and Insurance Regulatory Commission and its agencies received and forwarded 28,554 complaints about insurance consumption in the second quarter. Among them, 10051 property insurance companies were involved, accounting for 35.20% of the total complaints; There were 18,503 life insurance companies, accounting for 64.80% of the total complaints. The number of complaints from PICC P&C ranks first among property insurance companies. The number of complaints in Ping An Life Insurance Company of China ranks first among life insurance companies.

　　According to the Circular, in the second quarter of 2022, the median number of complaints about 100 million yuan premium of property insurance companies was 3.58 pieces/100 million yuan, and the median number of complaints about 10,000 policies was 0.36 pieces/10,000 pieces; The median number of complaints about 100 million yuan premium of life insurance companies is 1.78/100 million yuan, the median number of complaints about 10,000 policies is 0.25/10,000, and the median number of complaints about 10,000 people is 0.08/10,000. Zhonghui Mutual Insurance ranks first among property insurance companies in terms of the complaints about the 100 million yuan premium. The number of complaints about 10,000 policies of Jiulong Property Insurance and Zhonghui Mutual Insurance ranks in the top two among property insurance companies. Fosun United Health ranks first among life insurance companies in terms of complaints about 100 million yuan premium, complaints about 10,000 policies and complaints about 10,000 people.

　　According to the Circular, in the second quarter of 2022, there were 7,808 complaints about claims disputes involving property insurance companies, accounting for 77.68% of the total complaints of property insurance companies; There were 822 complaints about sales disputes, accounting for 8.18%. Zhonghui Mutual Insurance, PICC P&C Insurance and Zhongan Online P&C Insurance rank among the top three property insurance companies. PICC P&C Insurance and Ping An P&C Insurance rank in the top two among property insurance companies.

　　In the second quarter of 2022, property insurance companies filed 4324 complaints about motor vehicle insurance disputes, accounting for 43.02% of the total complaints of property insurance companies; There were 2,434 complaints about other insurance disputes involving property insurance such as COVID-19 epidemic isolation insurance, accounting for 24.22%. PICC P&C ranked first among property insurance companies in the number of complaints about motor vehicle insurance disputes. Zhonghui Mutual Insurance and Zhongan Online Property Insurance are among the top two property insurance companies in terms of complaints about property insurance related to COVID-19 epidemic isolation and other insurance disputes.

　　According to the Circular, in the second quarter of 2022, there were 9,613 complaints about sales disputes from life insurance companies, accounting for 51.95% of the total complaints from life insurance companies. There were 5011 complaints about surrender disputes, accounting for 27.08%. The number of complaints about sales disputes and surrender disputes in Ping An Life Insurance Company of China ranks first among life insurance companies.

　　In the second quarter of 2022, there were 8101 complaints about ordinary life insurance disputes from life insurance companies, accounting for 43.78% of the total complaints from life insurance companies; There were 4182 complaints about sickness insurance disputes, accounting for 22.60%. The number of complaints about ordinary life insurance disputes in Ping An Life Insurance Company of China ranks first among life insurance companies. Ping An Life Insurance Company of China and Xinhua Life Insurance ranked the top two in terms of complaints about sickness insurance disputes among life insurance companies.

Ashton Kutcher, the American movie star who plays Jobs, has just joined Lenovo Group. According to the USA-Today website, Kucher signed a cooperation agreement with Lenovo on the evening of 29th local time to serve as Lenovo’s product engineer and spokesperson.

Lenovo held a new product launch conference in Los Angeles at 7 o’clock that night, and launched the world’s first "legged" tablet computer &mdash; &mdash; Yoga tablet. The conference was broadcast live on Youtube for global users to watch. At the press conference, Kucher held a Yoga tablet computer, just like the way Jobs introduced Apple’s new products. After the conference, Kucher will meet Lenovo engineers and executives in China in the future.

Kucher introduces Lenovo Yoga tablet computer.

Kucher said at the press conference that modern people often encounter two situations in their daily lives: lying in bed and using a tablet computer is easy to slip into their face because of their hands; The battery of a tablet or smart phone is useless, so everyone has to bring a brick-like mobile power supply. These two common details made the audience laugh, which is indeed an experience that many people have had. The new products launched by Lenovo just solved these two problems: the small bracket liberated people’s hands; The battery life that can work continuously for 18 hours on a single charge can help people reduce the weight of their backpacks. In addition, you can also charge your smartphone with a tablet computer, and the USB interface on the tablet computer can easily achieve this.

Lenovo’s new tablet has 8-inch and 10-inch versions, and the price is $249 and $299 respectively. These two products will be available from October 30, just in time to "play against Taiwan" with the Apple tablet iPad Air, which was officially released on November 1. However, Lenovo’s products are much cheaper than Apple’s iPad Air, and the lowest price of the new generation iPad is $499.

Kucher, 35, graduated from the University of Iowa in the United States, majoring in biochemical engineering (but didn’t graduate). She was once kicked out of her dormitory because she was too noisy and crazy. However, he is now Walden Schmidt, the hero of the popular comedy Two and a Half Heroes, which was launched by CBS in the United States, and also a famous angel investor in Silicon Valley. In addition to Skype, Kucher’s investment also includes Foursquare, Flipboard and Path.

Kucher at the new product launch is very much like Jobs.

Kucher has also cooperated with Google and Apple. When talking about why he joined Lenovo, Kucher said, "Lenovo’s hardware is very, very good. I want to make their products as consumer-friendly as possible. " Kucher will make suggestions on the design and software of Yoga tablet.

USA-Today said that this cooperation is a prepared risk for both sides. And Kucher said that this is precisely the reason why he joined Lenovo. "If you look back on my career, you will find that I have always liked adventure &mdash; &mdash; Lenovo, too, "Kucher said.

Phoenix. com said that some fruit fans commented that Kucher had joined Lenovo: He should know more about Apple culture after playing Jobs, and now it’s a bit disappointing to advertise Lenovo for money. It seems that he is not a real fruit fan. Since he is not a fruit fan, no wonder he can’t play Jobs well.

Lenovo and Kucher did not disclose the salary of this cooperation.

Stills of the movie Jobs

　　CCTV News:In order to improve people’s attention to chronic kidney disease (CKD), the International Society of Nephrology (ISN) and the International Foundation for Nephrology (IFKF) jointly designated the second Thursday of March every year as "world kidney day". March 14th, 2019 is the 14th world kidney day, and this year’s theme is "Kidney Health for All".

　　On March 17th, more than 200 leaders, nephrologists and medical staff, including Yang Min, Vice President of Chinese Medical Doctor Association, Jin Dapeng, Chairman of Nephrology Branch of Beijing Medical Association, Chairman of Nephrology Branch of Chinese Medical Doctor Association, and Academician Chen Xiangmei, Chairman of Nephrology Committee of China Society of Integrated Traditional Chinese and Western Medicine, gathered in national hotel, Beijing, and read out the "world kidney day Proposal in 2019" and started academic exchanges around this year’s theme.

　　"Everyone enjoys kidney health" aims to further raise people’s attention to the high burden and important harm of kidney diseases around the world, improve the prevention and management strategy of kidney diseases, and call for comprehensive health coverage, prevention and early treatment of kidney diseases. Encourage people to adopt a healthy lifestyle, screen high-risk groups, ensure that patients with kidney disease get the basic health services they need, such as basic physical examination, laboratory tests, and essential drugs, delay the progress of the disease as much as possible, and strengthen advanced health care capabilities to ensure the health of the whole people’s kidneys.

　　However, as one of Chinese’s favorite "tonic" organs, does the public really know about kidneys? Therefore, persistent popularization of popular science is the most important work for medical staff during their stay in world kidney day, which has been done by Beijing nephrologists for 14 years. Every year, through a large number of new media publicity, free clinics, doctor-patient friendship, knowledge lectures and other forms, medical common sense and knowledge of CKD prevention and treatment are popularized to the public, so that many Beijing citizens have obtained correct knowledge of kidney disease. On March 14th this year, on the same day in world kidney day, kidney disease experts from 16 hospitals in Beijing, including xuanwu hospital of Capital Medical University, Fourth Medical Center of the People’s Liberation Army and People’s Hospital of Peking University, walked into Luhe Hospital of Tongzhou affiliated to Capital Medical University and held free clinic and popular science publicity activities. The scene was very warm. "We issued a call to the whole country, and the kidney health of the people in the city and the kidney health of the people all over the country started from this! This is what Beijing experts should do, and it is also what Beijing experts have done well and have always insisted on doing. " Academician Chen Xiangmei affirmed the popular science work of kidney disease in Beijing in the past 14 years.

　　Is your kidney healthy?

　　Academician Chen Xiangmei said in his speech at this conference that this year’s government work report clearly puts chronic diseases at the national prevention and treatment level, and our theme this year, "Kidney health for all", is to extend from disease to the concept of great health, which is very macroscopic and in line with the pulse of the times, in line with the pulse of deepening reform of medical and health undertakings, and what we should do when we enter a new era.

　　At present, compared with cardiovascular disease and diabetes, the popularization of chronic kidney disease in China is not extensive enough, and the medical literacy of the general public needs to be improved. They lack the awareness of actively understanding medical common sense and fail to fully understand the knowledge of preventing kidney disease in time. Moreover, the problem of "expensive and difficult to see a doctor" still exists, which makes some patients fail to see a doctor in time or have regular physical examination. These are important reasons why chronic kidney disease is not easy to be found early.

　　If chronic kidney disease is not prevented early, the condition will gradually progress until uremia develops; It not only damages the health and labor ability of patients, but also brings great pain to patients and even endangers their lives; At the same time, it will also greatly increase the economic burden of patients’ families and society. In fact, the low rate of early prevention and control has brought serious consequences. About 20%-30% patients with kidney disease often find that the renal function damage has developed to an irreversible level when they first visit the hospital.

　　But how can the public judge whether their kidneys are healthy?

　　In fact, it’s very simple, just a simple physical examination. Urine protein and red blood cells in urine routine can basically provide clear signals related to kidney disease.

　　"The key to early interventional therapy is to insist on regular screening every year. Even if there are no symptoms, it is generally necessary to screen urine routine and renal function once a year. If you have hypertension, diabetes, etc., you should check it every six months as appropriate; If you already have certain symptoms, you should go to the hospital for a comprehensive physical examination as soon as possible. " This year’s brochure of world kidney day clearly points out the ways and means.

　　Prevention and treatment of kidney disease starts with healthy living.

　　In recent 30 years, with the improvement of living standards and working conditions of Chinese people, some changes have taken place in people’s traditional lifestyle, such as excessive intake of certain nutrients (carbohydrates, fat, salt, etc.) and reduced physical activity; At the same time, work stress, mental stress, lack of sleep, smoking, alcoholism, environmental pollution and other factors have increased the incidence of metabolic diseases such as hypertension, diabetes, hyperlipidemia, hyperuricemia and obesity, resulting in an increasing prevalence of chronic kidney disease. In addition, drug-induced renal damage caused by drug abuse or irregular use of drugs also showed a significant increase trend.

　　In the academic exchanges at the conference, Professor Li Yuehong’s "What kind of harm does beauty and hairdressing do to the kidney", Professor Tu Xiaowen’s "Smoking and drinking do harm to the kidney", Professor Li Zhongxin’s "The four high protections are not in place, and the kidney is not small", Professor Xiao Yuefei’s "I don’t care if I have a cold and fever, but my kidney is hurt by improper medication" and Professor Zhou Yilun’s "What should I do to protect my kidney" are all easy to understand from the perspective of daily life.

　　At present, the incidence of kidney disease in China is as high as 10.8%, and there are about 130 million CKD patients in China. Looking around the world, there are about 850 million people suffering from kidney disease in the world for various reasons. CKD causes at least 2.4 million deaths every year, and it is currently the sixth fastest growing cause of death.

　　Therefore, Academician Chen Xiangmei suggested that "the participation of the whole people should make people fully realize that CKD is a preventable and treatable disease, understand the characteristics of common diseases, be familiar with the basic knowledge of self-management of diseases, master the skills of healthy lifestyle, and gradually enhance the awareness of disease prevention. It is necessary to change unhealthy lifestyles such as overeating, smoking, excessive drinking and lack of exercise, and prevent and control obesity, hyperlipidemia, hypertension, hyperglycemia, hyperuricemia and abuse.

　　At the same time, experts attending the meeting also called on the whole society to pay more attention and help to CKD patients in spirit, psychology, work, family, economy and life, and strive to gradually realize the beautiful vision that everyone can master medical common sense and enjoy healthy kidneys.

Liam Neeson talks to the mystery man with a serious face.

1905 movie network news A few days ago, the action suspense film has met the audience in North America. The action scenes of life and death and the suspense reversal of wits have made the film gain excellent box office results and word of mouth after its release. With a series of films, liam neeson, who successfully created the screen to "rescue professional households", once again "returned to his old job". As an ordinary white-collar uncle, he was not only accidentally involved in a conspiracy, but also single-handedly searched for a mysterious passenger on the commuter train in new york and eliminated the danger, which was exciting and suspenseful.

The Commuter tells the story of Macaulay, the hero played by liam neeson, who meets the mysterious girl Joanna on his way home by commuter train in new york. Joanna offered Macaulay a tempting task &mdash; &mdash; Find out a passenger in the car and get a huge sum of cash in return. But in the process of searching, Macaulay gradually found himself not only involved in a deadly conspiracy, but also unable to quit, and a rescue operation full of suspense and excitement began. When the commuter train close to everyone’s life scene becomes a runaway and deadly journey, how Uncle Liam can solve the puzzles lurking in the commuter train and rescue the passengers is expected.

Liam Neeson turned into a white-collar uncle, running for his life.

With a series of screen roles to rescue relatives in distress, liam neeson deserves to be a "rescue specialist" in Hollywood. In Taken3 series films, he plays a retired agent who chases across many countries and rescues his daughter and wife from foreign evil organizations. Whether it is a sharp and professional lynching trial or a quick skill of one enemy and ten, the image of a loving father who is eager to save a woman and the fierce domineering of fighting violence with violence have made him numerous; In the movie, liam neeson, who plays the plainclothes air marshal, changed the battlefield again, fighting wits and wits with the hijackers lurking among the passengers at high altitude, reversing Gan Kun in the air at the peak of 10,000 meters, finding out the black hand behind the scenes from the clues, and at the same time, fighting hand-to-hand in the narrow cabin to rescue the passengers of the whole plane &hellip; &hellip;

It can be said that with a series of invincible rescue operations, Uncle Liam not only successfully created an IP movie with the theme of "rescue", but also made himself a leading figure in Hollywood action heroes and won fans all over the world to call him crazy.Different from films such as Taken3 and NON-STOP, the role played by liam neeson in The Commuter no longer has the aura of skills such as special agent and air marshal, but becomes a white-collar office worker. Playing an ordinary person in an action movie for the first time, he not only had to make a living, but also struggled with the complicated and demanding needs of his boss and customers. At the age of 60, he lost his job and lost his direction in life, and he didn’t know how to face his family and future. It is a challenge for talented liam neeson to play such an ordinary middle-aged man who is involved in a life-and-death rescue operation at the same time. In the film, liam neeson, who was laid off, was lured by the mysterious girl into a gambling conspiracy because of the pressure of life.

Liam neeson moved the wrench to rescue the commuter train.

Jaume serra, the director who has cooperated with liam neeson for four times, praised Uncle Liam’s performance. He recalled his experience in shooting The Commuter, saying, "Every day when shooting, I am like a child looking forward to a Christmas present, waiting for the performance surprise brought by Nelson. His style and his eyes, he can completely change and create new roles with various nuances."

Not only is it more interesting in acting, but the action scene of the film is also thrilling. In the closed tense and high-speed train space, liam neeson should not only race against time to crack the true identity of the man behind the scenes, but also use all props in the train to fight, constantly resolve the dangerous ambushes and rescue the passengers on the train. The gradual reversal of the plot and the rapid and sharp action scenes have all upgraded The Commuter’s performance and action scenes.

In addition to liam neeson, the film The Commuter also featured famous Hollywood movie stars Vera Farmiga, Patrick Wilson and sam neill, and was directed by NON-STOP’s Hollywood genius jaume serra. The film has been released in North America and is expected to be introduced to Chinese mainland in 2018.

Recently, the news that actor Kathy CHAU passed away at the age of 57 made many people feel sorry, and also made people feel the fragility and impermanence of life.

On December 27th, Kathy CHAU’s sister issued a statement saying that according to the surveillance video and the appraisal of the forensic department, it was comprehensively judged that Kathy CHAU had a sudden heart attack.

For a time, the relationship between female menopause and cardiovascular health has also attracted many people’s attention. Previous studies have pointed out that women after menopause should pay special attention to heart health.

Postmenopausal women

Increased risk of heart disease

Why do women have an increased risk of heart disease after menopause? In fact, this is related to the changes in hormone levels in women.

In 2014, a study on the protective effect of estrogen on women’s cardiovascular system published in China Clinical Journal of Obstetrics and Gynecology pointed out that estrogen plays a very important role in preventing cardiovascular diseases besides regulating reproductive system. The increase of the incidence of coronary heart disease in postmenopausal women is closely related to the significant decrease of estrogen level in postmenopausal women. ①

Previous epidemiological surveys have shown that the age of female coronary heart disease is 10-15 years later than that of male, and the incidence of female coronary heart disease before menopause is only 1/10-3/10 of that of male, but the incidence and mortality of coronary heart disease in postmenopausal women have increased significantly. ②③

In June 2018, a study published in the journal of American Heart Association, Sex Hormones and Cardiovascular Diseases in Postmenopausal Women, also showed that the increase in the ratio of testosterone to estradiol (a kind of estrogen) in postmenopausal women was related to the increased risk of myocardial infarction, stroke and heart failure. The higher the testosterone level, the greater the risk, and the higher the estradiol level, the lower the risk. Every standardized unit of testosterone-estrogen ratio increases the risk of cardiovascular disease by 19%, coronary heart disease by 45% and heart failure by 31%. ④

Heart alarm signal

Be regarded as menopausal discomfort

After menopause, many women mistake some symptoms that may be heart disease, such as chest tightness, wheezing when walking, heart pounding and so on, as the inevitable phenomenon of menopause, but ignore that this may be an alarm signal sent by the heart.

Xu Guochen, former deputy chief physician of the Department of Cardiology, Fourth Medical Center, General Hospital of the People’s Liberation Army, once reminded in a health newspaper article that before menopause, high levels of estrogen in women’s bodies made it difficult for blood vessels to harden and block; After menopause, estrogen in women is greatly reduced, and the heart and blood vessels lack buffering adaptability, so the incidence of cardiovascular diseases rises sharply. In addition, the endocrine level changes in menopause, autonomic nervous dysfunction, there will be upset, sweating and other symptoms, easy to make people mistakenly think that menopause syndrome is not taken seriously. ⑤

Dr. Xu Guochen said that if menopausal women often have symptoms such as extreme fatigue, dizziness, nausea, palpitation, fainting, shortness of breath, chest pain or feeling pressure on their back and upper body, they should pay attention to it and go to the hospital for examination in time.

Sharla Cheung Zhou, chief physician of the Chest Pain Center of Guangdong Provincial Hospital of Traditional Chinese Medicine, published an article on WeChat WeChat official account in Guangdong Provincial Hospital of Traditional Chinese Medicine in 2022, saying that menopausal women have symptoms of palpitation, chest tightness, poor sleep and irritability, so it is best to go to the hospital to have an electrocardiogram first and make a preliminary screening for heart diseases. Sometimes, although the ECG is normal, if there are high-risk factors such as hypertension, hyperlipidemia, diabetes, obesity, smoking, alcoholism and family genetic history of heart disease, it is best to do another exercise load test (that is, running ECG). If there are ischemic changes, it is suspected that you have coronary heart disease, and it is recommended to go to a cardiology specialist for further diagnosis and treatment. ⑥

Health times data map

Women after 50 years old

Take care of your heart.

1. Control physical indicators.

Doctors in Sharla Cheung said that menopause and old age are irresistible, and only by controlling the controllable factors can cardiovascular diseases be effectively prevented. Controlling the controllable factors is that obese people should lose weight properly, smokers and alcoholics should quit smoking and limit alcohol, and patients with hypertension, diabetes and dyslipidemia should control their blood pressure, blood sugar and blood lipids well. ⑥

2. Pay attention to the health of diet

Appropriate supplementation of milk and bean products such as soybean milk, tofu, soybean milk and other foods rich in estrogen and milk with high calcium content. Eating fruits, vegetables and fish is also beneficial food. Avoid eating greasy and full meals, which will increase the burden on the stomach and the risk of obesity.

3. Exercise can delay aging

Proper exercise can delay aging. For postmenopausal women, it is a simple and effective exercise method to take a walk every day and practice Qigong or Baduanjin, but it is based on the principle of not being tired and full of energy after exercise, and remember to persevere.

4. Keep a cheerful mood

Increasing social communication makes people feel happy, which is an important factor in preventing and treating diseases, avoiding being too excited and overworked, so as to avoid too much burden on the heart.

This article is synthesized from:

① Plateau, Huining. Study on the protective effect of estrogen on female cardiovascular system [J]. China Clinical Journal of Obstetrics and Gynecology, 2014(1):3.

②Rosano G, Vitale C, Spoletini l, et al. Cardiovascular health in the menopausal woman: impact of the timing of hormone replacement therapy.Climacteric，2012，15: 299-305

③Huang T,Yang B, Zheng J, et al. Cardiovascular Disease Mortality and Cancer Incidence in Vegetarians: A Meta-Analysis and Systematic Review. Ann Nutr Metab, 2012. 60:233-240.

④Di Zhao, et al. Endogenous Sex Hormones and Incident Cardiovascular Disease in Post-Menopausal Women. J Am Coll Cardiol. Volume 71,Issue 22, June 2018

⑤ June-October, 2013 Health Times "Beware of Heart Alarm after Menopause"

⑥2022-07-07 《 Shaping Heart School | Care for the Heart after Menopause 》 by Guangdong Provincial Hospital of Traditional Chinese Medicine.

Source: Health Times

　　Zhengzhou, Zhengzhou, July 24 th (Henan Taiwan reporter Zhou Wenru) According to the Voice of China News Night, "the car loan is zero down payment, and the car drives home". You can drive the car home without spending a penny. Such a "good thing" sounds really tempting. But is there really such a free lunch? In the end, Mr. Xu from Zhengzhou, Henan Province met a businessman who promised to pick up the car with zero down payment. So did he really buy the car without spending a penny? Is buying a car with zero down payment a "pie" or a "trap"?

　　At the beginning of this year, Mr. Xu, a citizen of Zhengzhou, took a fancy to a car in an automobile sales company in the North Ring Road of Zhengzhou. Mr. Xu said that he chose to buy a car in this sales company precisely because the merchant promised to pick up the car with "zero down payment". According to the regulations, Mr. Xu also paid a deposit of 10,000 yuan. The company promised that the rest of the money would be paid in advance by the company. After picking up the car, he would handle the second loan for Mr. Xu. After deducting the expenses, he could drive away.

　　After paying the deposit, Mr. Xu waited at home for the car sales company to go through the car installment payment procedures, and then picked up the car, but there was no news from the left and right. Mr. Xu went to the company for consultation, but was told that he had to pay a series of fees such as commercial insurance and purchase tax before picking up the car.

　　"Zero down payment" literally means that the customer borrows money to buy a car, and does not need a down payment, just needs to repay the loan on a monthly basis. This is actually very tempting for many people, especially young people. The reporter learned that at present, most of the so-called zero down payment car purchases in the car purchase market are made by 4S stores for promotion, but they are actually operated by auto finance institutions and small guarantee companies. A salesperson of a 4S shop in Zhengzhou revealed that the down payment part of the zero down payment is made by the company itself, and the purchase tax and insurance can be funded by a third party. "To put it bluntly, it is a kind of private lending, and then they pay interest."

　　This mode of operation usually advances the full amount to help customers pick up their cars, buy insurance and get a license. When customers have assets, they can apply for credit cards from many banks, and then cash out their credit cards to recover their investment. Mr. Zhu, who has worked in a 4S shop for a long time, told reporters that in this case, consumers only have the right to use, not the ownership. After the sales company helps customers pay the down payment, the car registration certificate is mortgaged. The name on the certificate is a small guarantee company or a guarantor. It will not be transferred to customers until all the money is paid off.

　　Auto financing companies will adjust the interest rate according to the down payment ratio of car buyers. The usual rule is that the higher the down payment, the lower the loan interest rate, while the zero down payment interest rate is relatively higher. Moreover, Mr. Zhu told us that when handling zero down payment through auto financing companies, customers are generally required to buy auto insurance in the 4S shop that handles car loans, and also to install a positioning system, so in the end, customers will not get benefits in terms of vehicle prices. After calculation, Mr. Zhu found that the zero down payment car purchase will be repaid in three years, and a car with a price of about 150,000 yuan will cost more than 30,000 to 40,000 yuan in handling fees and interest. The 4S shop also requires a GPS with a price of more than 3,000 yuan. "

　　In the whole process of zero down payment, auto finance companies have to charge high fees for handling credit cards for customers. The handling fee for a credit card with a limit of 100,000 yuan is 15%, which is 15,000 yuan.

　　It is understood that Article 22 of the Measures for the Administration of Automobile Loans jointly promulgated by the Central Bank and the China Banking Regulatory Commission stipulates that the amount of loans for self-use by lenders shall not exceed 80% of the price of automobiles purchased by borrowers, that is, "zero down payment" is not allowed and recognized by law, which is illegal. Jiang Gongmin, executive vice president of Henan Automobile Industry Association, pointed out that zero down payment cars are usually mortgage cars in stock, and it is very risky to buy them by this unreasonable and illegal method.

　　The staff of Zhengzhou Industrial and Commercial Bureau reminded consumers that there is no free lunch in the world, and consumers should not be greedy for petty gains. To buy a car, you should go to a regular car store or exhibition hall. You can consult the bank or apply directly to the manufacturer’s finance for buying a car by stages.

　　The 2023 Guangdong Network Civilization Conference opened in Guangzhou on September 21st.

　　Southern Network News (Reporter/Wang Xichen Weng Junting) Civilization is booming and the Internet is booming. On the morning of September 21st, the 2023 Guangdong Internet Civilization Conference was held in Guangzhou with the theme of "Gathering Up the Strength for Good and Cultivating a Healthy and Simple Culture". The meeting pointed out that it is necessary to thoroughly implement the important thought of the Supreme Leader’s General Secretary about the cyber power, fully implement the spirit of the 20th Party Congress, implement the deployment requirements of the China Cyber Civilization Conference in 2023, firmly grasp the correct direction, insist on the online publicity and education of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era as the primary task, vigorously carry forward and practice the socialist core values, and actively cultivate an upward-oriented, vigorous and simple cyber culture. We will continue to promote the mass spiritual civilization creation activities to extend to the Internet, continue to deepen the comprehensive management of the Internet, effectively gather the strong synergy of building and sharing a beautiful spiritual home on the Internet, and create a good network environment for our province to take the lead in promoting Chinese modernization.

　　Academicians and big coffees gathered together to talk about the construction of network civilization in Guangdong.

　　Carry forward the new style of the times, and thoughts are stirring here.

　　The opening ceremony of the 2023 Guangdong Network Civilization Conference and the main forum set up a cross-border integration platform, presenting a grand gathering of ideas and fruitful results.

　　Participants conducted in-depth exchanges and discussions on topics such as solidly promoting the organic integration and mutual promotion of online and offline civilization construction and building a beautiful spiritual home online, providing cutting-edge thinking for promoting the construction of online civilization in Guangdong.

　　He Jingtang, Academician of China Academy of Engineering and Dean of Architectural Design and Research Institute of South China University of Technology, gave a keynote speech.

　　"Just as architecture is a space that carries aesthetics in the real world, cyberspace also needs to carry beauty and spread beauty." In the keynote speech, He Jingtang, academician of China Academy of Engineering and dean of Architectural Design and Research Institute of South China University of Technology, took the Guangzhou National Edition Pavilion designed by him as an example to explain the commonality between cyberspace and architectural space. In his view, architectural space and cyberspace are both carriers of the inheritance of Chinese civilization, and both need people to promote their blooming humanistic beauty from the aspects of inheritance and innovation, rules and order.

　　Hou Xiaojun, vice president of Southern Newspaper Media Group and president of Southern News Network, gave a keynote speech at the scene.

　　Hou Xiaojun, vice president of Southern Newspaper Media Group and president of Southern News Network, introduced the specific practice of Southern News Network singing "Southern Network Voice" in cyberspace. "It is incumbent on the online media to make the Millennium civilization last forever in cyberspace and let the mortal starlight gather into a torch in everything."

　　Lin Dihuan, the creator of "Kobayashi Comics", shared his creative story on the spot.

　　Lin Dihuan, the founder of "Kobayashi Comics", used vivid and interesting case stories to share his thoughts on civilized internet access and civilized internet use with netizens. The customs of Lingnan nourish this artistic creator from Zhanjiang, Guangdong. Advocating the new trend of network civilization, he constantly enriches the aesthetic connotation in two dimensions: excellent traditional culture and spiritual growth.

　　Tell the story of good netizens in South Guangdong and condense the positive energy of cyberspace.

　　To practice network civilization, we start from here.

　　The opening ceremony and main forum of the 2023 Guangdong Network Civilization Conference focused on the achievements of all walks of life in Guangdong around the construction of network civilization, and conveyed the good wishes of netizens for building a network civilization together.

　　The story of "Top Ten Good Netizens in South Guangdong" in 2023 was announced on the spot.

　　Since July this year, the Network Information Office of Guangdong Provincial Party Committee and Guangdong Civilization Office have held the story selection activity of "Top Ten Good Netizens in South Guangdong" in 2023. After layer-by-layer selection, 10 excellent stories of "Good Netizens in South Guangdong" stand out from nearly 200 stories of netizens.

　　Internet experts who sing Lingnan culture, media people who comment on news hotspots, life mentors of young students, rural culture recommenders, and positive energy communicators who are keen on public welfare & HELIP; &hellip; At the conference, ten winners of the story of "Top Ten Good Netizens in South Guangdong" appeared one by one. Their stories showed the positive role played by Guangdong netizens in promoting the construction of a strong network province, promoting the main theme of the network, participating in the governance of the network society and prospering the network culture from different angles.

　　The conference invited the "most beautiful" representatives such as the national moral model, the model of South Guangdong, the good people in Guangdong and the craftsmen in South Guangdong to present honorary certificates to the winners of the story of "Top Ten Good Netizens in South Guangdong" respectively, so as to realize the two-way trip of the good people, the warm circulation and the mutual reflection of the good. Nathan Chen and Zhang Junhui, the winners of the story of "Top Ten Good Netizens in Southern Guangdong", shared their stories of network civilization on the spot.

　　Representatives of netizens issued a proposal to help the flower of civilization fill the cyberspace.

　　The construction of network civilization needs the joint efforts of all walks of life. "Let’s join hands to build a network civilization and strive to write a new chapter in the modern civilization of the Chinese nation!" At the conference, the winners of the story of "Top Ten Good Netizens in South Guangdong" jointly issued the Proposal of "Converging Up for Good to Cultivate a Healthy and Simple Culture", and issued the initiative of "striving to be a practitioner of great thoughts", "striving to be an excellent cultural cultivator", "striving to be an advocate of civilized new trends" and "striving to be a defender of network order" to the whole network, calling on the netizens to actively participate in the construction of network civilization and jointly promote civilized internet operation, civilized internet use and civilized internet access.

　　The 2023 Guangdong Network Civilization Conference was hosted by Guangdong Provincial Party Committee Network Office and Guangdong Civilization Office, hosted by Southern News Network and co-organized by Guangdong Internet Industry Federation. The conference was held in the form of "1+1+4", namely, an opening ceremony and main forum of the conference, an Internet conference for children in Guangdong-Hong Kong-Macao Greater Bay Area, and four thematic forums, including network content construction, network rule of law construction, network integrity construction, civilized practice and network public welfare.