Xinhua News Agency, Beijing, February 21st(International observation) The annual report on trade with China is greatly popular. There is no market for "decoupling theory"

　　Xinhua news agency reporter

　　Recently, many major economies in the world published the annual trade reports with China in 2022, and a number of bilateral trade data with China reached record highs, with frequent highlights of economic and trade cooperation, showing that economic and trade ties with China are getting closer and cooperation with China’s supply chain is more resilient.

　　International observers believe that the red-hot annual trade reports of major economies with China have greatly boosted the confidence of countries in China’s economy and win-win economic and trade cooperation with China, and also clearly showed that the "decoupling theory" advocated and manipulated by American politicians with China is not accepted by the market.

　　Closer ties: the trade volume with China has reached record highs.

　　Looking at the trade data of major countries and regions with China in 2022, many countries and regions have stronger trade performance with China than with other major trading partners, which not only maintains the growth trend, but also exceeds their overall foreign trade growth rate.

　　According to data released by the US Department of Commerce on the 7th, according to US statistics, the total trade volume of goods between the United States and China in 2022 reached US$ 690.6 billion, a record high. The American media believe that it is "surprising" that the US-China trade data reached a new high in 2022, considering that the United States has imposed tariffs on China’s goods exported to the United States for many years and that the US government has blocked the exchanges between China and the United States on the grounds of "national security", which fully proves that bilateral economic and trade relations are still close.

　　According to data released by Eurostat on the 15th, the total trade volume of goods between Europe and China reached 856.3 billion euros in 2022, an increase of about 23% compared with 2021, which also reached a new high.

　　According to the latest data from the German Federal Statistical Office, the total trade volume between Germany and China rose to a record level of 297.9 billion euros in 2022, an increase of about 21% compared with 2021, which was higher than the overall growth rate of German foreign trade in the same period. China has become the most important German trading partner for the seventh consecutive year.

　　Juergen Martes, an expert at the German Economic Research Institute, said that China’s economy is huge, and the economic and trade ties between Germany and China are closer. No one wants to and cannot "decouple" from China.

　　According to the data released by the General Administration of Customs of China, in 2022, the bilateral trade volume between China and Africa, ASEAN and Latin America reached US$ 282 billion, US$ 975.3 billion and US$ 485.8 billion respectively, increasing by 11.1%, 11.2% and 7.7% respectively compared with 2021, all of which were record highs.

　　Former Croatian Minister of Economy Ljubo Jurcic told Xinhua News Agency that although the COVID-19 epidemic has brought some impact, China’s economy has maintained a relatively high growth rate for many years, which is the "locomotive" for stimulating world economic growth. Politicians and media in a few western countries concocted the decoupling theory with China because they ignored or didn’t want to see the fact that the world was closely linked with China.

　　More dividends: complementary advantages to achieve a win-win situation

　　Under the market law of complementary advantages and mutual benefit and win-win, the economic and trade cooperation between countries with China is full of vitality.

　　In view of the new trend of German-Chinese trade in 2022, the German Economic Research Institute reported that the increase in international energy and raw material prices aggravated inflationary pressure, and affordable goods produced in China were more favored by the German market. In addition, German enterprises have gradually increased their investment in China and localized production, which is also reflected in the trade data.

　　In the past year, automobiles were the main highlight of bilateral trade between Mexico and China. According to the data of National Geographic Statistics Bureau of Mexico, in 2022, China cars accounted for nearly a quarter of the imported cars in Mexico. China has surpassed the United States, Japan and other countries to become the main source country of Mexican imported cars.

　　According to the latest data from the National Statistics and Census Institute of Argentina, China will be Argentina’s second largest export destination and largest import source in 2022. Compared with 2021, Argentina’s import and export of goods to China in 2022 increased by 29.4% and 27.4% respectively.

　　Pablo Levinton, a professor of economics at Ranus National University in Argentina, believes that the economies of Argentina and China are highly complementary. Argentina’s high-quality beef, red wine and other products are welcomed by the China market, and Argentina’s lithium, copper and other mineral resources are also needed by China’s new energy industries.

　　The North Africa Post commented that Africa-China trade reached a new high. Africa has expanded its exports to China with the advantages of natural resources such as crude oil, copper, cobalt and iron ore, while China’s products such as machinery, electronics and textiles meet the demand of the African market.

　　Bambang Suryono, Chairman of the Asian Innovation Research Center, an Indonesian think tank, said that the bilateral trade volume between Indonesia and China increased by nearly 20% in 2022 compared with the previous year, and China continued to be Indonesia’s largest trading partner, demonstrating the high correlation and complementarity between the two economies. China is Indonesia’s largest export market, and its rapid economic growth will greatly promote Indonesia’s economic and social development.

　　More Confidence: Looking forward to the "East Wind" in China Market

　　Looking forward to the new year, many institutions and analysts are optimistic about the prospects of China-foreign trade and economic cooperation, and believe that China’s economy will make generate more dynamic and bring more market opportunities and development dividends to the world.

　　According to Chilean customs statistics, Chile’s exports to China in 2022 were US$ 38.106 billion, accounting for 38.9% of the country’s total exports. China has been Chile’s largest trading partner since 2009. Nearly 90% of Chile’s cherry exports are sold to China market.

　　"The China market is too important for us!" Ivan Marambio, president of the Chilean Fruit Exporters Association, said. After China implemented the temporary measures for personnel exchanges between China and foreign countries in early January, he led a delegation to visit several cities in China to negotiate with business partners. "We are optimistic about China’s market resilience and consumption vitality, and hope to achieve greater development through the China market".

　　In 2022, China became Brazil’s largest trading partner for the 14th consecutive year. According to official Brazilian data, Brazil’s exports to China reached US$ 89.428 billion last year, accounting for 26.8% of the country’s total exports.

　　Jose Ricardo Luce Jr., CEO of Brazilian business leaders’ organization in China, said that the deepening economic and trade partnership between Brazil and China has had a positive impact on the development of Brazil’s agriculture, infrastructure, science and technology and e-commerce. Bilateral trade between Pakistan and China has continuously hit new highs, which has contributed greatly to Brazil’s economic growth and will further promote exchanges between the two sides in various fields.

　　The African Development Bank released a report in January, raising the economic growth forecast of Africa to 4% in 2023. According to the report, after China optimizes and adjusts its epidemic prevention policy, Asia, as an important export market of Africa, will achieve steady growth, thus expanding the development space of Africa.

　　Ralph Klein, general manager of German Haoting Electronics Company, said that China has great market potential, and China’s economy has a great influence on the development of German enterprises in China, expecting China’s economy to achieve more positive development and faster growth.

　　According to the data released by the National Bureau of Statistics on February 17th, in 2022, China was the second largest trading partner of Britain in terms of goods import and the fifth largest trading partner in terms of goods export. Zhang Zhikai, a scholar at Durham University in the UK, believes that British exports to China have increased, driven by diversified trade demand. British business circles are actively promoting economic and trade exchanges between Britain and China, and bilateral trade is expected to grow further this year.

　　Zhengzhou, Zhengzhou, July 24 th (Henan Taiwan reporter Zhou Wenru) According to the Voice of China News Night, "the car loan is zero down payment, and the car drives home". You can drive the car home without spending a penny. Such a "good thing" sounds really tempting. But is there really such a free lunch? In the end, Mr. Xu from Zhengzhou, Henan Province met a businessman who promised to pick up the car with zero down payment. So did he really buy the car without spending a penny? Is buying a car with zero down payment a "pie" or a "trap"?

　　At the beginning of this year, Mr. Xu, a citizen of Zhengzhou, took a fancy to a car in an automobile sales company in the North Ring Road of Zhengzhou. Mr. Xu said that he chose to buy a car in this sales company precisely because the merchant promised to pick up the car with "zero down payment". According to the regulations, Mr. Xu also paid a deposit of 10,000 yuan. The company promised that the rest of the money would be paid in advance by the company. After picking up the car, he would handle the second loan for Mr. Xu. After deducting the expenses, he could drive away.

　　After paying the deposit, Mr. Xu waited at home for the car sales company to go through the car installment payment procedures, and then picked up the car, but there was no news from the left and right. Mr. Xu went to the company for consultation, but was told that he had to pay a series of fees such as commercial insurance and purchase tax before picking up the car.

　　"Zero down payment" literally means that the customer borrows money to buy a car, and does not need a down payment, just needs to repay the loan on a monthly basis. This is actually very tempting for many people, especially young people. The reporter learned that at present, most of the so-called zero down payment car purchases in the car purchase market are made by 4S stores for promotion, but they are actually operated by auto finance institutions and small guarantee companies. A salesperson of a 4S shop in Zhengzhou revealed that the down payment part of the zero down payment is made by the company itself, and the purchase tax and insurance can be funded by a third party. "To put it bluntly, it is a kind of private lending, and then they pay interest."

　　This mode of operation usually advances the full amount to help customers pick up their cars, buy insurance and get a license. When customers have assets, they can apply for credit cards from many banks, and then cash out their credit cards to recover their investment. Mr. Zhu, who has worked in a 4S shop for a long time, told reporters that in this case, consumers only have the right to use, not the ownership. After the sales company helps customers pay the down payment, the car registration certificate is mortgaged. The name on the certificate is a small guarantee company or a guarantor. It will not be transferred to customers until all the money is paid off.

　　Auto financing companies will adjust the interest rate according to the down payment ratio of car buyers. The usual rule is that the higher the down payment, the lower the loan interest rate, while the zero down payment interest rate is relatively higher. Moreover, Mr. Zhu told us that when handling zero down payment through auto financing companies, customers are generally required to buy auto insurance in the 4S shop that handles car loans, and also to install a positioning system, so in the end, customers will not get benefits in terms of vehicle prices. After calculation, Mr. Zhu found that the zero down payment car purchase will be repaid in three years, and a car with a price of about 150,000 yuan will cost more than 30,000 to 40,000 yuan in handling fees and interest. The 4S shop also requires a GPS with a price of more than 3,000 yuan. "

　　In the whole process of zero down payment, auto finance companies have to charge high fees for handling credit cards for customers. The handling fee for a credit card with a limit of 100,000 yuan is 15%, which is 15,000 yuan.

　　It is understood that Article 22 of the Measures for the Administration of Automobile Loans jointly promulgated by the Central Bank and the China Banking Regulatory Commission stipulates that the amount of loans for self-use by lenders shall not exceed 80% of the price of automobiles purchased by borrowers, that is, "zero down payment" is not allowed and recognized by law, which is illegal. Jiang Gongmin, executive vice president of Henan Automobile Industry Association, pointed out that zero down payment cars are usually mortgage cars in stock, and it is very risky to buy them by this unreasonable and illegal method.

　　The staff of Zhengzhou Industrial and Commercial Bureau reminded consumers that there is no free lunch in the world, and consumers should not be greedy for petty gains. To buy a car, you should go to a regular car store or exhibition hall. You can consult the bank or apply directly to the manufacturer’s finance for buying a car by stages.

　　　　CCTV.com News: In response to an article published by the media recently that the bronze prize work "The Qinghai-Tibet Railway opens a life channel for wild animals" was fraudulent, CCTV International website interviewed the heads of relevant CCTV departments exclusively on February 16th.

Event playback

Alleged fake photo: "Qinghai-Tibet Railway opens up a life channel for wild animals"

Netizens pointed out that there are three frauds in the photo.

　　　　The person in charge said that The Annual Selection of CCTV Photo News Affecting 2006 was sponsored by CCTV, undertaken by China FotoPress, and sponsored by Xinhua Daily Telegraph, Workers Daily, China Youth Daily, Beijing Evening News and Xinmin Evening News. The jury consists of senior professionals such as China Photographers Association, Xinhua Daily Telegraph, Workers Daily, China Youth Daily, China Daily, People’s Photography, China News Weekly, China News Service, China Photography and Xinmin Evening News.

　　　　Among the seven selection rules announced to the public, the first one emphasizes that "all entries must conform to the recognized principle of authenticity in the photo contest." The original image shall not be changed for the entries. The organizer does not modify the participating works. " In view of the works submitted by professionals, the selection also clearly stipulates that "the entries must be original works shot after January 1, 2006 and published in domestic legal media." During this period, from thousands of published photos, the organizing committee of the selection activity finally selected ten photos with the first, second and third prizes after initial evaluation and re-evaluation. Liu Weiqiang, a reporter from Daqing Evening News, won the bronze prize for his news photo "Qinghai-Tibet Railway opens a life channel for wildlife" taken on June 23, 2006.

　　　　The person in charge said that the reason why the Qinghai-Tibet Railway opens a life channel for wild animals was selected was that the news picture had been published by Xinhua News Agency and other media; Second, the author himself thinks that the picture is original and meets the requirements of the selection rules. In view of whether the picture is original or not, the reporter also specially tuned the program materials of the award party at that time. The following is the dialogue between CCTV host Annabel Lee and Liu Weiqiang at the awarding ceremony-

　　　　Annabel Lee: First of all, congratulations to you, Liu Weiqiang. I also want to tell you that Liu Weiqiang got the news the latest among all our winners today. When did you get the news?

　　　　Liu Weiqiang: The day before.

　　　　Annabel Lee: I just found out the day before. Where were you when our staff called you?

　　　　Liu Weiqiang: In no man’s land, no man’s land in Hoh Xil.

　　　　Annabel Lee: So you’ve had a hard time getting here, haven’t you?

　　　　Liu Weiqiang: I didn’t plan to come here after I got the news, because it’s the mating season for Tibetan antelopes, and this moment is rare, but I think since I can be given a chance, I’ll get here anyway.

　　　　Annabel Lee: You think it’s an opportunity for Tibetan antelope to receive the prize.

　　　　Liu Weiqiang: I think so.

　　　　Annabel Lee: Look at this photo of you. What are the chances that you, the train and the Tibetan antelope will be in the same time and space in a no-man’s land at an altitude of four or five kilometers?

　　　　Liu Weiqiang: In the language of photography, this is a moment, very short, because the Tibetan antelope, a creature, is very timid by nature, and it has run away when people are far away. When I took this photo, I dug a bunker in front, which was more than half a meter deep. I was in the bunker and covered it with something, so the Tibetan antelope was lucky enough to rush to my camera from the opposite side. Actually, it was only a few seconds when the Tibetan antelope passed by, but I waited in the bunker for eight days.

　　　　Annabel Lee: Eight days?

　　　　Liu Weiqiang: Right.

　　　　Annabel Lee: Eight days. Does eight days mean eight days and nights? Eight 24 hours?

　　　　Liu Weiqiang: Almost eight 24 hours.

　　　　Annabel Lee: When you wait until the seventh day, how do you know that the sheep will definitely come on the eighth day? What should I do if I don’t come on the eighth day and the tenth day?

　　　　Liu Weiqiang: I will wait. In fact, I also know that even if I wait for eight days or even eighteen days, I may not be able to wait for this moment. But as a reporter, I should stick to it for a beautiful moment. I can wait, let alone eight days, eighteen days and twenty-eight days, because I have been shooting Tibetan antelopes since March.

　　　　Annabel Lee: Tibetan antelope is the subject of this group of photos. The place you chose, trains and tracks are very important subjects. What is the purpose of taking this photo here?

　　　　Liu Weiqiang: I want to show the harmony between Tibetan antelopes, trains, people and nature on July 1, 2006. I want to express it with one of my pictures, because the earth belongs to everyone, and the harmony between people and animals is what everyone expects.

　　　　Annabel Lee: Did you rush to our site to receive the prize? Will you go back immediately or go home to have a look?

　　　　Liu Weiqiang: I will fly back to Golmud on my plane tomorrow, because the mating season of Tibetan antelopes is very short. I have photographed all the four seasons of Tibetan antelopes in one year, except for the last scene of Tibetan antelopes’ love. I want to get it. At this time next year, I will call on 2.7 million Daqing people to donate money to Tibetan antelopes in China in the name of Daqing Evening News, as long as my picture can make everyone know more about Tibetan antelopes and Tibetan antelopes.

　　　　During the interview, the person in charge told reporters that CCTV attaches great importance to relevant media reports, and is closely monitoring the progress of the situation with the composition of the jury and professionals, and will make further responses and treatments based on the survey results.

Editor: Huo Junxia

　　CCTV News:Since the beginning of this year, regional integration in the Yangtze River Delta has continuously improved the toughness and vitality of foreign trade. With the help of innovative logistics system and customs clearance facilitation, the Yangtze River Delta region has overcome the adverse effects brought by the epidemic and promoted the sustained and good development of foreign trade import and export.

　　At Jiangsu (Suzhou) International Railway Logistics Center, this train loaded with LCD, semiconductor and other commodities will be sent to Luchao Port in Shanghai and shipped to North America by sea. Here, "sea-rail combined transport" has become the norm. At the same time, in the absence of an airport, Suzhou copied the customs clearance mode of "sea-rail combined transport" with the logistics center as the front cargo terminal, and opened up a new channel of "land-air combined transport" to meet the air freight demand of enterprises.

　　The "land-air combined transport" train has also been normalized in Suzhou International Railway Logistics Center, and the daily delivery volume has remained at around 30 tons. At this point, the goods in the logistics center can go out by any combination of "road, railway, air and sea", attracting more and more enterprises from the Yangtze River Delta region to join in. At present, among more than 3,000 enterprises, enterprises outside Jiangsu account for nearly half.

　　The export of goods is more convenient, and many cross-border e-commerce enterprises in Shanghai have chosen Hangzhou, Ningbo and other places for customs clearance of imported goods. At Ningbo lishe airport International Cargo Terminal, Wang Wushan, the logistics manager of this cross-border e-commerce company in Shanghai, is receiving the goods that have just arrived from the United States. Wang Wushan told reporters that although the enterprise is in Shanghai, the innovative measures of cross-border e-commerce transit in the Yangtze River Delta region allow enterprises to quickly clear customs in Ningbo, and goods can be shipped directly from Ningbo, and users in Jiangsu, Zhejiang and Shanghai can receive the parcel delivery information the next day.

　　Since the beginning of this year, Ningbo has undertaken many e-commerce businesses spilled from Shanghai and other places. For these imported goods, the local customs actively promoted the cross-border e-commerce transit business in the Yangtze River Delta region and opened various transit channels such as "air-to-air", "air-to-land" and "air-to-sea".

　　Various convenient measures have boosted the foreign trade in the Yangtze River Delta region to continue to improve. The data shows that in the first eight months, the growth rate of imports and exports in the Yangtze River Delta region was 1.5 percentage points higher than the national overall growth rate, and its contribution to the national foreign trade growth exceeded 40%, which provided strong momentum for stabilizing the foreign trade market.

There is an old saying in Chinese,

It’s called "no painting, no year"

In ancient times without cameras,

The beauty of Gusu City,

Are condensed in the Taohuawu woodblock New Year pictures.

Suzhou Taohuawu Woodblock New Year Pictures,

It is also called "Southern Peach and Northern Willow" with Tianjin Yangliuqing Woodblock New Year Pictures.

It originated from the engraving printing process in Song Dynasty.

In 2006, it was selected as the first batch of national intangible cultural heritage.

Jiangnan’s delicate euphemism,

Nourishes the Taohuawu woodblock New Year pictures.

The artistic style of "Fine beautiful and elegant".

Jiachen the Year of the Loong,

Qiao Mai, Representative Inheritor of Taohuawu Woodblock New Year Pictures

"Cross-border" creation of the zodiac New Year picture "Hidden Dragon Garden".

She will C919, chip breakthrough and other elements.

Ingeniously integrated into the creation of New Year pictures.

Don’t use a hidden dragon, or jump in the deep,

It means that the long-accumulated energy is coming to generate.

"Love at first sight" more than 20 years ago,

The fate of Qiao Mai and Taohuawu woodblock New Year pictures was achieved.

She said that New Year pictures are a kaleidoscope of beautiful people.

It is also Chinese’s paper utopia.

Carrying our yearning for a better life.

Producer | Geng Zhimin

Producer | Peng Yiran

Master planner | Yu Tenglong

Director | Wang Shuaitian

Camera | Lai Jian Yan Dong

Editing | Wei Weicheng Wang Lian

Audio editing | Wang Anran

Vision | Wang Su

Animation | Zhou Wenlei

Overall planning | Yang Bo Liu Xiao Jin Yi Jie

Co-production | Li Jiabao, Gao Lei, Li Peng

Acknowledgement | Suzhou Public Cultural Center Jiangsu Education Channel of Suzhou gusu district Education, Sports and Cultural Tourism Committee

"Since the beginning of this year, China’s foreign trade import and export has achieved rapid growth, quality and efficiency have been further improved, foreign trade development has maintained a steady and positive trend, and accelerated from ‘ Big entry and big exit ’ Towards ‘ Excellent entry and excellent exit ’ 。” Liang Ming, director of the Institute of Foreign Trade of the Ministry of Commerce, said that the 123rd Canton Fair, for example, attracted more than 200,000 merchants, up 5.3% year-on-year, the highest level in five years. The cumulative export turnover was 189.197 billion yuan, up 3.1% year-on-year, the highest level in the Spring Fair in four years. This also means that since the 119th session, the buyers and export turnover of Canton Fair ushered in the fifth "double growth", which once again sent a positive signal.

Liang Ming believes that at present, China’s foreign trade presents four distinct characteristics:

First, the growth rate is relatively fast. From January to May this year, the total import and export volume of China’s goods trade reached US$ 1,814.45 billion, up 16.8% year-on-year. Among them, the export value was US$ 957.06 billion, up 13.3% year-on-year; Imports amounted to US$ 857.39 billion, a year-on-year increase of 21%. Judging from the growth rate of foreign trade in the first five months of the calendar year, the growth rate of China’s foreign trade this year is the highest in seven years.

The second is structural optimization. In terms of trade patterns, in the first five months, China’s general trade exports amounted to US$ 542.43 billion, accounting for 56.7% of China’s total exports in the same period, an increase of 2.7 percentage points over the same period last year; General trade imports amounted to $534.95 billion, accounting for 61.2% of China’s total imports in the same period, an increase of 1.1 percentage points over the same period last year. In terms of trade goods, in the first five months, China’s exports of mechanical and electrical products were US$ 563.27 billion, accounting for 58.9% of China’s total exports in the same period, an increase of 1.6 percentage points over the same period last year; The export volume of labor-intensive products was US$ 176.19 billion, accounting for 18.4% of China’s total exports in the same period, which was 1.9 percentage points lower than that in the same period last year.

The third is to improve efficiency. In the first five months, the import of some important equipment, key parts and high-quality consumer goods increased rapidly, among which the import of integrated circuits, electromechanical products and high-tech products increased by 35.8%, 23.3% and 25% respectively; The import of energy resources products increased rapidly, which ensured the domestic market demand and eased the resource constraints faced by economic development. The import volume of crude oil, iron ore, refined oil, copper and other bulk commodities maintained rapid growth, with growth rates of 8%, 0.7%, 12.4% and 16.7% respectively.

The fourth is to be more balanced. In the first five months, the growth rate of China’s imports was generally faster than that of its exports, and the trade surplus of goods was US$ 102.81 billion, down by 29.1% compared with the same period of last year. China’s market was further opened to the world.

"The rapid growth of China’s import and export is the result of many factors." Liang Ming believes that at present, the world economy is recovering moderately and the growth rate of international trade is obvious. The development trend of China’s economy, which is progressing steadily and improving steadily, has been continuously consolidated, which has driven the sustained and rapid growth of imports, and the relevant foreign trade support policies have gradually exerted their efforts to achieve results. From the market perspective, the "Belt and Road Initiative" has been steadily promoted, and the development of emerging markets has given strength, and the ability of enterprises to bravely enter the international market has also been continuously enhanced.

"In the second half of the year, foreign trade will continue its steady and rapid development momentum. It is expected that the quality, structure and efficiency of China’s foreign trade will be further improved this year. " Liang Ming said that China’s foreign trade is stable and supportive, and it faces new development opportunities. According to the latest report of Global Trade Data and Outlook released by the World Trade Organization, the growth forecast of global trade volume in 2018 will be greatly raised from the previous 3.2% to 4.4%, which is significantly higher than the average annual growth rate of 3% after the international financial crisis.

Liang Ming believes that it is necessary to continue to promote the liberalization and facilitation of trade and investment, maintain the multilateral trading system, and intensify efforts to cultivate new trade formats and modes. While stabilizing exports, we will actively expand imports, make full preparations for the first China International Import Expo, increase the import of products with distinctive advantages where people’s needs are concentrated, and promote the balanced development of foreign trade import and export. I believe that the openness of China’s foreign trade field will continue to increase in the future, and the prospect of coordinated and sustainable development of trade can be expected.

On September 8, China Huaxin Energy Co., Ltd., the largest private enterprise in Shanghai, acquired 14.16% of the shares of Rosneft, with an estimated contract value of about 9.1 billion US dollars. Upon completion of the acquisition, Huaxin became the third largest shareholder of Rosneft, second only to the Russian government (holding 50.00000001%) and BP (holding 19.75%).

According to the 8th news of CBN, Ye Jianyi, Chairman of China Huaxin Board of Directors, said, "We are very happy to be the strategic shareholder of the world’s largest listed oil company and to carry out comprehensive strategic cooperation with Rosneft. This cooperation has further consolidated and promoted China Huaxin’s position in the oil and gas field. China Huaxin looks forward to the in-depth cooperation with Rosneft, and will make great efforts to promote the joint cooperation between Rosneft and China market, so as to provide strong support for meeting China’s energy demand. I firmly believe that this transaction will inject new energy into the promotion of Sino-Russian economic and trade cooperation. "

On June 14th, Ye Jianyi, Chairman of China Huaxin Board of Directors, met with Igor Sechin, CEO of Russian oil company. /data map from the network

On the evening of September 8th, Beijing time, Glencore, a global commodity giant headquartered in Barr, Switzerland, announced that a consortium formed by it and Qatar Investment Authority had reached an agreement with CEFC of China, and the former transferred its 14.16% stake in Rosneft to China Huaxin.

According to the announcement, the price for China Huaxin to acquire the equity of Rosneft is 16% higher than the average price of 30 days before September 8. According to the calculation of Rosneft’s total share capital, the 14.16% equity acquired by Huaxin accounts for about 1.502 billion shares, and the average share price before September 8 and 30 is about 5.13 USD. Based on this calculation, Huaxin’s purchase price is about $9.1 billion.

The announcement also shows that the transaction is still subject to regulatory review.

It is reported that this transaction is the largest upstream transaction in the global oil industry since Shell Oil acquired British Gas Group (BG) in 2015. At the same time, it is also the second largest overseas oil and gas acquisition in the history of China’s oil industry, second only to China CNOOC’s acquisition of Nexen Company for US$ 15.1 billion in 2012.

Upon completion of this acquisition, China Huaxin will become the third largest shareholder of Rosneft, second only to the Russian government (holding 50.000000001% through JSC ROSNEFTEGAZ) and BP (holding 19.75%).

Glencore official website Announcement

Rosneft is the largest oil company in Russia and the largest listed company in the global oil and gas industry. Its business covers 35 countries and regions including North America, Brazil, Vietnam, Venezuela and Mozambique, and its oil and gas equivalent output reached 265 million tons in 2016. This means that Huaxin will acquire the oil rights and interests of 42 million tons of oil and gas reserves every year with a total amount of 2.67 billion tons, ranking among the largest oil companies in the world, and will become a new important link between Russian oil and China market.

Earlier, according to the Securities Times reported on the 7th, the day before the official announcement of the acquisition, the market has heard the news that Huaxin shares in Rosneft. At that time, relevant persons of Huaxin Group told the newspaper that the company had held several talks with Rosneft and signed a strategic cooperation contract, and relevant information had been released in official website. However, regarding whether or not to take a stake in Rosneft, it only responded that there is no new information to disclose at present.

According to Huaxin Energy official website and Russian oil company official website, there have been frequent interactions between the two sides in recent months.

On June 14th, Ye Jianyi, Chairman of Huaxin Board of Directors, met with Igor Sechin, CEO of Rosneft in Moscow. The two sides reached broad consensus on mutually beneficial and win-win comprehensive strategic cooperation in the fields of oil and gas resources development, crude oil and refined oil trade and financial services, and agreed to set up a joint working group to promote bilateral cooperation as soon as possible to achieve substantive results and sign relevant cooperation agreements.

On July 4th, Rosneft said that it signed a strategic cooperation agreement with China Huaxin and reached an agreement to consider establishing a vertically integrated joint venture company in Russia to carry out oil and gas projects and establish a joint investment fund.

On August 12th, Igor Sechin led a delegation to visit Huaxin Headquarters in China, and the two sides signed a strategic cooperation framework agreement. The energy and financial teams of the two sides also held further discussions and consultations on the projects involved in the agreement, and determined specific investment projects and plans.

On September 3rd, Rosneft and Huaxin signed a strategic cooperation agreement, which will start oil and gas exploration and development cooperation in Siberia. Xie Qin said, "The signing of this common agreement is a complete demonstration of Russian oil strategy. The primary strategy of Russian oil is to strengthen relations with Asia-Pacific countries, especially China."

In addition, on August 28th this year, Zang Jianjun, executive director of China Huaxin, attended the opening ceremony of the 2017 World Judo Championships in Budapest, Hungary. During this period, Zang Jianjun was received by Russian President and Honorary President of the International Judo Federation Putin. It is reported that Putin is concerned about China Huaxin’s investment cooperation in Russia, and expressed support for China Huaxin.

In addition to active cooperation with Rosneft, China Huaxin is also actively seeking cooperation with another famous Russian enterprise, Russian Basic Elements Group. The Russian Basic Elements Group is the second largest consortium in Russia and one of the largest diversified industrial groups in the country, and its business involves energy, finance, mining and manufacturing. Since the second half of this year, the two companies have conducted many exchanges and reached a consensus on long-term strategic cooperation.

Huaxin has repeatedly shot in the oil and gas field.

Ye Jianyi, Chairman of the Board of Directors of China Huaxin once said, "The vision of China Huaxin is very simple, that is, to obtain overseas resources and serve the national strategy." It is reported that Huaxin Energy is the largest non-state-owned energy company in China, and its revenue in 2015 is close to two-thirds of CNOOC’s.

Ye Jianyi, Chairman of the Board of Directors of China Huaxin/Data Map from the Internet

According to media analysis, unlike most upstarts in China who are competing to "go global", Huaxin always focuses on the oil and gas field.

According to public information, based in Europe, Huaxin has laid out oil and gas terminals, acquired Kazakhstan National Oil International Company, owned a large refinery with the latest equipment in Romania, owned more than 1,000 gas stations and hundreds of oil depot transfer stations in countries around the Mediterranean Sea and the Black Sea, such as France, Spain and Romania, and has formed a large-scale oil and gas terminal integrating refining, processing, storage, transportation and sales in Europe.

In addition, in line with the "Belt and Road Initiative", Huaxin set up its second headquarters in Georgia to integrate upstream oil and gas rights and interests through the establishment of funds and asset securitization, ensure stable oil and gas supply, and continuously expand upstream oil and gas resources rights and interests in Abu Dhabi, Chad, Kazakhstan, Russia and Iran. Layout key oil and gas logistics nodes outside China, build a diversified energy storage and transportation system at home and abroad, establish a swap mechanism for oil reserves in Europe, the Middle East and China, and realize linkage between domestic and international markets.

For example, on February 20th this year, Huaxin signed an agreement with the Abu Dhabi government and Abu Dhabi National Oil Company (ADNOC) to acquire 4% interest in the land concession contract block in Abu Dhabi, with a contract period of 40 years and an investment of US$ 1.8 billion, including an entry fee of US$ 888 million.

According to the China Energy News on September 9th, the enthusiasm of China enterprises in the "Belt and Road" construction continues to rise, and the influence of private enterprises cannot be ignored. According to the big data analysis of the National Information Center, among the top 50 enterprises in China, central enterprises account for 36%, local state-owned enterprises account for 20%, private enterprises account for 42%, and joint ventures account for 2%. Among them, Huaxin is particularly eye-catching because of its rapid development speed and achievements. This year, Huaxin ranked 222nd in the Fortune Global 500 list with an operating income of US$ 43.7 billion, up seven places from last year. This is the fourth consecutive year that the company has been included in the Fortune Global 500 list. What is the order of magnitude of 222 bits? Ranked 216th on the list is China Merchants Bank, and ranked 226th is Lenovo Group.

In fact, in addition to the energy field, the company also quickly obtained a series of "full licenses" for financial business, including banking, securities, insurance, trust and so on. However, Ye Jian, the head of Huaxin, is extremely low-key and mysterious. As Huaxin received more and more attention from the outside world, Ye Jianyi was interviewed by Fortune magazine last year, telling the internal structure, concept and strategy of Huaxin Company. It is reported that Huaxin, with the approval of Shanghai Municipal Committee and Shanghai Social Work Committee, established the CPC Huaxin Party Committee, Discipline Inspection Commission, Trade Union and Youth League Committee, making efforts to create an integrated work pattern of "Party, Discipline, Industry and Youth League", forming an overall joint force and enhancing the internal cohesion of enterprises.

Special feature of 1905 film network Tiger resigns from the old year, and Jade Rabbit announces the spring.New Year’s gift in the Year of Rabbit, the movie channel is ready!

Come and open this New Year gift package together!

The first broadcast was heavy

From the second day of the Lunar New Year to the eighth day (January 23 — January 29th), a large number of domestic movies with rich themes, diverse types, excellent reputation and excellent box office results will meet the audience on the movie channel for the first time!

"I want to bring everyone back to China. This is my responsibility."

Leading the National Day file in 2022, the first domestic film focusing on the evacuation of overseas Chinese by diplomats tells the story of a group of "unarmed" diplomats who, under the test of life and death, took their compatriots home from the war-torn Numia and the rebels.

Unlike previous films of the same type, this film does not focus on the heroes who fought in off the charts. Every diplomat in the film is an ordinary person.

As People’s Daily commented: "In a foreign country, they represent China as a flag, a bunker, a lighthouse and a shield. Even if the’ return journey’ is long and full of thorns, you only need courage and faith, and flesh and blood can be paved. "

The film adapted from Korean cartoonist Zhao Shi’s cartoon of the same name is a rare attempt at space comedy.

After 2020, the "Shen-Ma Combination" broke out with greater energy in Moon Man.

The film is wrapped in a sci-fi coat, and Mahua FunAge’s consistent comedy style, coupled with the blessing of "Shen Ma Combination", is enough to attract attention.

Focusing on the bottom people and vulnerable groups, this paper tells the story of a group of migrant workers under the background of Shenzhen’s rapid development.

Movies show their true side and let the audience see how stupid children who never give up and are always full of hope and strength can create miracles.

As the director said, "Miracle is not the end, but the direction." "Miracle Stupid Child" allows us to gain not only the emotion of the story itself, but also the strength to forge ahead.

Less obvious drama conflict, pun dialogue left blank, and different types of female roles … …

It is not only about love, but also a Shanghai story with family, friendship and love, which is grounded and modern under the direction of female directors.

"One world, one mother."

While continuing the highlights of directing the road comedy, it shows the greatness of maternal love.

The framework of script killing includes suspense and comedy elements. The structure is exquisite and full of similes and metaphors, but the core is full of gentleness and kindness, which makes people laugh and move. The vine festival in the story is worth the audience’s repeated aftertaste.

A dream in existence — — He and his co-star, he used more than 1700 special effects shots to bring a wonderful mecha battle to the audience.

The rich and exciting martial arts drama starring Liu Qingyun will definitely make you enjoy it during the Spring Festival.

Audiences who like war movies must not miss the movie, which restores the true historical story and explains the power of faith.

Pay tribute to the most beautiful strugglers

From the second day of New Year’s Day to the fifteenth day of the first month (from January 23rd to February 5th), every morning, the film channel will broadcast a number of positive energy films that show the spirit of the new era and pay tribute to the most beautiful strugglers, including the winning films of the 16th "Five One Projects" for spiritual civilization construction.

Among them, there is the first person who rushed to fight poverty in China.

I gave up my job opportunities in big cities from the movie HUANG WENXIU, and resolutely returned to my hometown. I led my team in Huang Wenxiu (ornaments), the frontline of poverty alleviation, to Academician Zhu Youyong (ornaments), who went to Haozhiba in Lancang to help the poor.

Their devotion and self-dedication have promoted China’s cause of poverty alleviation to a comprehensive victory.

They promoted the great rejuvenation of the Chinese nation.

Wang Jicai and his wife (ornaments) who have been guarding the border island of the motherland for 32 years in the movie The Islander, Huang Danian (ornaments), a strategic scientist who brought great changes to China’s science and technology in the movie Huang Danian, Wuhan medical staff who struggled in the front line of fighting the epidemic in the movie Chinese Doctors, and Liu Qing (ornaments), a young writer who created the epic masterpiece The History of Entrepreneurship reflecting the collective entrepreneurship of the socialist people in the movie Liu Qing.

Their advanced deeds of growing up and struggling together with the motherland inspire us to move forward all the way.

At the same time, from New Year’s Eve to the morning of the sixth day (January 21-January 27), the movie channel will broadcast six cinema films with high reputation and positive energy that reflect the spirit of the times.

"Do you know that you may not get down if you go up?" "I know, but it’s worth it!"

What is Chinese-style rescue? It means giving up one’s life and forgetting oneself, without hesitation.

The film "Peak Explosion", which is also an award-winning film of the "Five One Project", takes us close to the railway infrastructure workers behind the "China Speed" and feels their Chinese rescue spirit in the face of disasters.

"There is no hero who can’t be frozen, and there is no hero who can’t be killed, only the honor of the soldiers."

Breaking 11 records in one fell swoop and firmly taking the top spot in the mainland box office, The Battle at Lake Changjin gave a three-hour audio-visual feast to show the Sino-US century showdown that happened on the Korean Peninsula more than 70 years ago as a documentary record, which made the patriotic feelings reach the hearts of the people.

These two films, which have extremely high ratings, are deeply loved by the audience of the movie channel. While celebrating the New Year, they don’t forget to remember this history.

Watch kung fu on holidays.

Eighteen martial arts films are indispensable on holidays.

The ninth to sixteenth days (January 30th — February 6), the movie channel will bring you different interpretations of different kung fu superstars during prime time every day.

Chinese, the first person to win the Oscar for Lifetime Achievement, brought a movie to celebrate the New Year with our screen.

In the movie "Depth Charge", he is the commander-in-chief of the international security team, and he is omnipotent.

"Go all out" creates "Zhen Kung Fu" and brings us peace.

The series of films made Donnie Yen bring the legendary IP Man to the public, and made mutual achievements with the characters, becoming an irreplaceable kung fu superstar on the screen. His role as a just policeman in Anger Serious Crime not only vividly reflects the actual action style of "Zhen Kung Fu", but also makes us feel the persistence in and out of Donnie Yen’s play.

The first person in the global Chinese box office list brings us a series of works this Spring Festival.

Jason Wu in "Wolf Warriors" and "Wolf Warriors II" will "play a soldier is not as good as a soldier" to the fullest, showing the unique bloodiness and tenderness of soldiers in China.

Those who "cut through thorns and thorns" will be in harmony and do their best to show the real kung fu of hard bridge and hard horse.

In Kung Fu League, he played another kind of Huang Feihong, and in Dangkou Fengyun, he turned into a national hero Qi Jiguang.

It can be said that it is the big brother of Hong Kong cinema. His acting skills can be switched freely, which is very interesting.

In the movie, he is a retired officer with his own jokes but amnesia, while in the movie, he becomes the head of Hongquan with a sharp look.

, capable of writing and martial arts, Yizhuang is also harmonious.

In school, he is a gangster, lame, fierce as a tiger, arrogant and piquant; Ever-changing, he grew long hair in the movie and played the evil Huang Yaoshi trapped in loved one, which was melancholy and charming.

It can be called the first idol in the Kung Fu era.

In Huo Yuanjia, Jet Li not only presents an exquisite visual feast of China martial arts, but also fully demonstrates the virtue and meaning of martial arts, as well as the Chinese martial arts spirit contained in China martial arts. Jet Li, under the fusion of new technology and film aesthetics, has taken us into the world of "new martial arts".

Celebrate the New Year with a New Year film.

How come there are so few New Year films in the Spring Festival!

From New Year’s Eve to the seventh day (January 21st — On January 28th), you selected the best New Year’s greetings since 2015 on the movie channel.

These include movies from 2015, 2016, 2017, 2018, 2019 and 2021.

In addition, after the sixth day of junior high school, the film channel also prepared a classic New Year movie screening for you.

Whether it’s the movie that started the "New Year’s Eve in the Mainland", the sequel to the New Year’s Eve movie while the iron is hot, the continuation of the civilian story, or the two series of funny and cured works starring, you will recall the good old days in the light and shadow.

Review the classic New Year movies together, each one is full of flavor!

Hot broadcast special session

From the first day to the sixth day (January 22 — On January 27th, in the afternoon, the movie channel will broadcast a variety of comedy cinema films to have a "New Year Joy Club" comedy party!

We have prepared three comedy cinema films with suspense in the funny.

The film takes you into the hilarious journey of revealing the shocking scam in the antique world; In the movie, Kung Fu superstar Donnie Yen turned into a fat man weighing 220 pounds and staged a different kind of Kung Fu comedy. After Bangkok and new york, another big case broke out in Tokyo, and a contest between the strongest detectives in Asia was hilarious.

The following three comedies can make people forget their troubles and laugh until they are full of rice.

Taking us to the bathhouse with super grounding gas, the wonderful collision between the north and the south bathing culture makes people laugh and cry; The dark horse at the box office takes you to the "set", and the interpretation of the play in the play firmly grasps the hearts of the audience; Identity exchange+crossing elements, teasing you in minutes is not negotiable.

After midnight during the Spring Festival holiday, there will be a series of films showing "Ten Years’ Collection of Channel Production", such as Yangmen Women’s Series, Lu Xiaofeng Series, Great Chinese Player Series, Kongchiser Series and Chinese Medicine Series.

Lu Xiaofeng, who has four eyebrows, Yang Jiajiang, who is loyal to the country, Yang Men, a heroine, Fan Xiping, a chess master, and Shi Xiangxia, a chess saint, as well as Zhang Qian, who went to the western regions, are waiting for you to learn something new!

The rabbit welcomes the spring and the year of the rabbit is good.

The countdown to the Spring Festival is coming, so collect this gift from the movie channel for the Year of the Rabbit!

Movie channel program preview

January 21st (New Year’s Eve)

Get home at one o’clock, Hi, Mom

This killer is not too cold.

January 22nd (New Year’s Day)

Detective Chinatown 3, The Climbers

January 23rd (New Year’s Day)

Island Keeper, Bath Buddy, The Battle at Lake Changjin

Believers ☆ Miracle Stupid Children ☆

January 24th (New Year’s Day)

Huang Danian.

Kung Fu Yoga and Li Mao Playing the Prince

The myth of love ☆ Lost in Russia ☆.

January 25th (New Year’s Day)

Academician of Farmers and Transcendence

Macau Fengyun 2, Antique close encounter of mahjong

☆ "Make a name for yourself" ☆.

January 26th (New Year’s Eve)

HUANG WENXIU’s "Peak Explosion" and "Macau storm riders"

The Fat Dragon Crossing the River, Miracle Stupid Child, Anger Serious Case

January 27th (Lunar New Year’s Day)

Leap, Island Keeper

Lost in Russia, Operation Red Sea

☆ "The Return of Wan Li" ☆.

January 28th (Lunar New Year’s Day)

☆ "Order to Serve the Gods"

The Wandering Earth

☆ Moon Man ☆

January 29th (Lunar New Year’s Day)

Make a name for yourself

☆

January 30th (New Year’s Day)

A Little Red Flower’s Party A and Party B

Depth Charge.

January 31st (Lunar New Year’s Day)

Liu Qing, Be there or be square

Wolf Warriors and War Wolf Ⅱ

Mark ☆ as the premiere film.

Please pay attention to the daily program preview for the specific broadcast time.

With the increasing demand for healthy, economical and convenient drinking water in the consumer market, the use scenarios of water purification equipment have become more diverse and comprehensive. Shanghai Pudao Shuihui Environmental Protection Technology Co., Ltd. (hereinafter referred to as "Pudao Shuihui") is a high-tech enterprise focusing on intelligent healthy direct drinking water, providing a new generation of intelligent water purification equipment and full-scene water purification solutions for business offices, hospitals, schools, government and enterprises, hotels and restaurants, manufacturing factories, large parks and other scenes. The company is a national high-tech enterprise, a Shanghai science and technology giant (cultivating) enterprise, a "specialized and innovative" small and medium-sized enterprise in Shanghai, and a member of China LoRa Application Alliance.

Park Road Water flows into the space where resident enterprises know about science and technology creation, and makes full use of the platform’s multi-module capabilities such as intellectual property management, scientific and technological information acquisition, and intelligent marketing to expand customers, so as to improve the company’s digital operation management level and technological innovation efficiency, and help China’s intelligent, healthy and direct drinking water industry move towards the "fast lane" of high-quality development.

Pudao Shuihui has been deeply involved in the field of water purification for more than ten years. It is the pioneer of "healthy water" in China, pays attention to the construction of innovation ability, takes the advantages of "healthy water+intelligence" as the engine of enterprise development, and continuously increases investment in research and development. The company set up a research and development center, equipped with technical research, product development and testing departments, and introduced sophisticated equipment, and built a number of teams including software and hardware and waterway system technical research, product management and structure development, intellectual property management, water quality and performance testing.

Thanks to its forward-looking strategic vision and strong scientific research strength, Park Dao Shuihui successfully applied IOT/ Internet of Things technology to the water appliance industry in 2014, becoming the first brand in China to create high-end intelligent healthy direct drinking water. The company’s research achievements have reached the advanced level in filtration technology, heating technology and intelligent management and control technology, and the innovative technologies introduced include DPM dynamic protein separation technology and DSC nano-single crystal shield Shi Ying heating technology. Using the advantages of intelligent equipment, intelligent operation and maintenance and big data, the company has built a Park Road Intelligent Cloud Platform, which realizes real-time monitoring of water quality status and equipment operation, fault warning and intelligent after-sales, and is the first in the industry to realize the life cycle management of healthy direct drinking water.

Park Road Shuihui independently developed a full range of products suitable for various scenarios, such as business offices, government and enterprise units, hospitals and schools, hotels and restaurants, retail chains, manufacturing plants, airport high-speed rail and so on. Taking the latest Warrior E6/E9 products as an example, the instant heating technology can continuously provide 100℃ real water to meet the demand of large-flow hot water drinking. The water tank-free design realizes standby zero energy consumption, saving more than 40% energy compared with the traditional energy-saving heating method, and the water outlet rate of purified water is ≥ 65%, better than the national first-class water efficiency standard.

Each product of Park Road Shuihui contains no less than 3 non-appearance patents and has undergone strict water quality safety testing. The company applied for about 150 patents, including 36 invention patents and 55 utility model patents, and participated in drafting a number of industry standards.

With advanced water purification technology and high-quality products and services, Park Dao Shuihui has built a service network covering more than 300 cities across the country, serving hundreds of Fortune 500 companies, Fortune 500 companies in China, and well-known institutions of higher learning. Healthy water has benefited more than 50 million people, with total sales exceeding 170 million yuan in the past three years. The domestic market share of self-developed tea water purification filtration equipment has exceeded 14%.

Park Road Shuihui has won many authoritative certifications in the world, such as national 3C certification, CQC quality certification, wading hygiene license, CDC water quality certification, CNAS certification, China Quality Inspection Association certification, international WELL system certification and so on, and won many honors.

With the advent of the digital economy era, the intelligent management system has been introduced to improve the digital level. Through the science and technology space, the whole cycle management of intellectual property application and maintenance is realized, and the whole process of product development is controlled through Teambition. The science and technology creation space provides all-round digital intelligence support for Park Road Shuihui, effectively improving the overall science and technology creation efficiency of the enterprise.

In the future, Park Road Shuihui will continue to improve its innovative management system, enhance its core competitiveness and market share in the water purification industry, and accelerate its building into a digital benchmark for the high-end intelligent water purification industry.

Product quality commitment: Park Road Shuihui pays attention to strengthening the construction of enterprise quality integrity culture. The product research and development team strictly controls a series of processes such as development, production and inspection to ensure product quality. At the same time, we will continue to strengthen the sense of responsibility and quality integrity of enterprises and consolidate the construction of product quality system.

Commitment to healthy water quality: At present, Park Dao Shuihui has established an R&D laboratory with R&D team leaders as the core. By continuously increasing R&D efforts and giving full play to its technological advantages, it strives to lead the trend of scientific and technological innovation in the industry, providing strong technical support for the quality assurance of intelligent healthy direct drinking water equipment and escorting healthy water quality throughout the process. At the same time, professional water quality testing can be carried out for users of Park Road Shuihui and a report can be issued, so that users can rest assured to drink water.

Service quality commitment: Park Road Shuihui promises to strictly screen products before sale, provide warm and meticulous service during sale, and provide all-round 360 butler service after sale. Relying on the intelligent management system, after-sales personnel can track the after-sales service in a timely, active and efficient manner to ensure a superior drinking experience for users. In addition, Park Road Shuihui has many successful service experiences of world-class companies, which makes the service commitment more secure.

Main products: PUDOW commercial direct drinking machine, household water purifier, kindergarten intelligent drinking water system.

http://www.pudow.cn

　　The frequent emergence of antibiotic resistance challenges modern medicine. It is very important to discuss the evolution of resistance to curb its global spread. The evolution of resistance involves a highly complex phenotypic heterogeneous response. Under the treatment of antibiotics, a small number of antibiotic-tolerant cell subsets will appear in the microbial flora with identical genes. The surviving subgroup can’t grow in the presence of antibiotics, but it can grow again after removing antibiotics, resulting in long-term recurrent infection, which is also the key reservoir for subsequent mutation of resistance genes. However, due to the complex heterogeneous response and stagnant growth of tolerance subgroups, it is still a challenge to identify tolerance subgroups from a large number of bacterial populations and track their physiological evolution trajectory.　
　　Recently, the team of Academician Zhu Yongguan from the Institute of Urban Environment, Chinese Academy of Sciences and Cui Li’s research group published in German Applied Chemistry. A research paper entitled an isotope-labeled single-cell Raman spectroscopy approach for tracking the physiological evolution of bacteria towards biological resistance was published. In this study, the heterogeneity of bacterial response was analyzed in situ at a high-precision level by developing a combination of single-cell Raman-deuterium isotope-multivariate statistical analysis, and the differentiation and dynamic changes of phenotypic subsets were sensitively identified from a large number of bacterial populations, which realized the rapid in-situ tracking of bacterial phenotypic physiological trajectory before resistance mutation, providing important guidance for curbing resistance evolution.　
　　In this study, bacteria were repeatedly exposed to clinical therapeutic doses of antibiotics, and antibiotic resistance evolved. In this paper, the in-situ activity of bacteria during evolution was detected by Raman spectroscopy of single cells labeled with heavy water in a culture-independent way. The results showed that the activity of bacteria under antibiotic pressure gradually increased with the treatment cycle without resistance mutation, indicating that its phenotypic tolerance gradually improved. Furthermore, the study uses UMAP multivariate statistical algorithm to analyze the single cell Raman fingerprint interval of thousands of bacteria in all evolutionary stages. According to the physiological response of bacterial phenotype indicated by Raman fingerprint, four phenotypic subgroups differentiated with the evolution of resistance were identified from bacterial populations with identical initial genotypes, namely sensitive flora, primary tolerant bacteria, evolution tolerant bacteria and evolution resistant bacteria, and the dynamic changes of the four subgroups with the evolution process were sensitively captured. So far, based on the heterogeneous response of bacteria in situ phenotype revealed by single cell Raman, researchers have drawn a physiological trajectory map of resistance evolution. Genome-wide sequencing of bacteria verified the revealed phenotype interactively, and analyzed the genetic basis of phenotype. Phenotypic differentiation is very important to maintain the survival and evolution of the whole flora. Because phenotypic differentiation is much earlier than resistance mutation, identifying phenotypic differentiation is of great significance for guiding clinical medication and reducing the occurrence of antibiotic tolerance and resistance mutation. In this study, the Raman spectra of four distinct subgroups were used to dig out the Raman marker peaks of tolerance and resistance mutation, which promoted the rapid and accurate identification of different stages of resistance evolution, especially phenotypic tolerance.　
　　The single cell analysis platform can be extended to a wider range of research on the evolution of resistance induced by antibiotics or non-antibiotic chemicals. In the future, the single-cell Raman can be combined with targeted single-cell sorting and multi-omics technology to realize the accurate correlation between tolerance and resistance phenotype and genotype, and promote the further explanation of evolutionary mechanism. The research work is supported by the "0 to 1" original innovation project of Chinese Academy of Sciences, the innovative research group project of National Natural Science Foundation of China and Fujian Natural Science Foundation.　
　　Paper link　
　　Tracking the evolution of bacterial antibiotic resistance by single cell Raman-isotope labeling-multivariate statistical analysis